Responsibilities:

* Manage all HR administration process.

* Handle recruitment process. Shortlist potential candidates and arrange for interview sessions.

* Administer work pass applications & renewals.

* Maintain leave and medical claim records.

* Responsible for payroll processing.

* Have a good understanding of HR practices in accordance to legislative requirements (Eg, CPF, IRAS & FWL, MOM) for Singapore.

* In charge of company's insurance matters such as renewal and claims.

* Handle issuing and manage inventory of uniforms and name tags.

Requirements:

1. Diploma in Human Resource/Business Management/Public Communication. Relevant professional certificate in related areas will be considered.
2. At least 5 years of working experience as HR generalist role.
3. Familiar with Singapore’s Employment Act and MOM regulations.
4. Possess good English verbal and written communication skills.
5. Able to work independently with minimal guidance.
6. Proper time management skills with the ability to multi-task while meeting deadlines.
7. Any other ad-hoc administrative duties as assigned.
8. Able to converse in basic Mandarin to communicate with non-English speaking staffs
9. F & B industry experience preferred but not mandatory.
10. Experience in managing Info-Tech Cloud HR System.

Staff Remuneration:

• Annual Wage Scheme (AWS) Annual / Childcare / Paternity / Maternity Leave / Medical & Hospitalisation Benefit
• Refer a Friend Monetary Scheme
• Newborn Baby Gift
• Yearly Birthday Gift
• Staff discounts

• Must have a diploma or bachelor degree with 5 years of experience.
• Must have knowledge in ms office and other basic computer skills.
• Willing to work on weekends and public holidays.
• Need to prepare the invoice nd project proposals for the new projects.
• Will be liasing wth the clients and coordinate with the authorities for the necessary paper work.
• Will ne scheduling the daily work process and will be incharge for the deployment of the team.
• Assist project manager to liaise with main con site personnel to solve problem on site for ongoing projects.
• Attend site meeting on behalf of the project manager when necessary
• Lead a team of installers on site to ensure the timely handover and the safety protocols
• Conduct training on the fabrication and installation works for the new workers
• Attend site survey for the new projects

chef is tasked with ensuring the kitchen runs smoothly, preparing food and sauces, and assisting head chefs with service. Candidates for this role need to be comfortable working in a fast-paced and often stressful work environment. They also need passion and enthusiasm for what they do. This is a full-time job and the hours are typically long, with weekend and evening work quite common. Work is usually performed in a well-lit industrial kitchen and in close quarters with colleagues. A role as a lead line cook would suit people who are passionate about cooking, enjoy a challenge, and like working as part of a team.

Key Responsibilities:

- To support product merchandising and stock replenishment at various locations.

- set up(early morning) and set down (at night) for counter/atrium activities at some period.
- arrange working schedule for promoter.

- Submit picking list to warehouse.
- Ad-hoc duties as assigned.

Requirements

- Relevant work experience is preferred but not necessary.

- Physically fit to support product merchandising and stock replenishment at the stores.

- Able to start work Immediately / short notice.

- 5.5 day work week

Benefits:
- Mobile Phone Allowance

- Transport allowance
- Attractive Commission Scheme
- Annual & Medical Leave Benefits

chef is tasked with ensuring the kitchen runs smoothly, preparing food and sauces, and assisting head chefs with service. Candidates for this role need to be comfortable working in a fast-paced and often stressful work environment. They also need passion and enthusiasm for what they do. This is a full-time job and the hours are typically long, with weekend and evening work quite common. Work is usually performed in a well-lit industrial kitchen and in close quarters with colleagues. A role as a lead line cook would suit people who are passionate about cooking, enjoy a challenge, and like working as part of a team.

Join Our Growing Team!

The SKYLINK Group is a premier all-in-one mobility solution provider for retail sales of passenger cars and commercial vehicles, all vehicle leasing, Motor insurance, credit Hire Purchase financing, Motor workshop with full capacity of MRO (Maintenance, Repair and Overhaul) services, and vehicle body engineering works for all commercial and passenger vehicles.

Since 2017, SKYLINK Group has been rapidly expanding its offerings and fleet. We have served over 5,000 corporate customers including major industry leaders in logistics, distribution, F&B, marine, construction, sanitation, and government services.

With a commitment to fleet modernization, we have expanded our offerings to EV and Hybrid vehicles, and continuously aspire to provide greater value to our customers.

Be a part of the SKYLINK family and kick-start your career growth and progression in the mobility space today.

Job Description:

• Manage the full recruitment process, from job posting and candidate sourcing to conducting interviews and coordinating with hiring managers.
• Partner with the department heads to identify staffing needs and ensure timely and effective hiring.
• Handle applications, renewals, and cancellations of work passes in the compliance with regulatory requirements.
• Serve as the primary point of contact for work pass matters, ensuring timely and accurate processing.
• Use Info-Tech software to manage HR functions, including e-attendance, leave applications, and claims submissions.
• Assist staff with the use of the Info-Tech systems, troubleshooting any issues and coordinating with relevant teams for support as needed.
• Manage end-to-end onboarding and offboarding processes, including preparing necessary documents, conduction tours, and handling exit formalities.
• Provide an orientation tour to all new hires, familiarizing them with the company culture, facilities, and key personnel.
• Prepare and distribute company memos and communications in both English and Chinese to ensure clear and effective communication across all levels.
• Support general office administration tasks as needed.
• Assist in organizing company festive events and celebrations, coordinating venues, and materials to promote team engagement and a positive workplace culture.

Job Requirement:

• Diploma or bachelor’s degree in human resources, Business Administration or a related filed.
• 1-3 years of HR experience including recruitment, preferably in the automotive or a similar industry.
• Proficiency in Info-Tech software is required.
• Strong proficiency in MS Office.
• Bilingual in English and Chinese, with the ability to prepare written communications in both languages.
• Strong communication and interpersonal skills, with the ability to interact with staff at all levels.

Job Description & Requirements

• Open the bakery early in the morning
• Clean kitchen equipment and tools before use
• Weigh flour and other ingredients to prepare dough
• Bake different bread types, like pretzels, baguettes and multigrain breads
• Adjust oven temperatures to ensure proper baking
• Mix various ingredients to create fillings for cakes and pies (e.g. chocolate ganache, caramel sauce and fruits)
• Decorate cakes with glazes, icings, buttercream and edible toppings, like flowers
• Shape dough to prepare different types of pastries, including croissants, cookies and sweet rolls
• Prepare custom-made pastries based on customers’ preferences (e.g. birthday cakes)
• Recommend recipes to renew our menu and attract more customers (e.g. gluten-free or vegan desserts)
• Track food supplies and place orders, as needed

Responsibilities

• General administrative support of the APAC HR function including sourcing, interview scheduling, general recruitment assistance, benefits administration and document management;
• Manage Human Resources Information System (HRIS) data entry;
• Manage monthly and quarterly reporting requirements for global and regional HR requirements;
• Collaborate with multiple internal departments on HR related needs;
• Assist with social media content for Medpace recruitment activities;
• Assist with on / off boarding matters;
• Perform special projects assigned;
• Handle sensitive and/or confidential employee information; and
• Any other ad-hoc duties assigned.

Qualifications

• At least Diploma or equivalent;
• Minimum of 1 years’ experience in a professional office setting;
• Proficient in Microsoft Word, Outlook, and Excel;
• Attention to detail; and
• Excellent organizational and prioritization skills.

JOB DESCRIPTION

• Developing age-appropriate socialization skills in children.
• Encouraging positive behavior and good manners.
• Using various learning methods such as stories, games, and drawing to intellectually stimulate children.
• Identifying behavioral problems and developing appropriate strategies to address them.
• Attending staff meetings, conferences, and workshops.
• Holding regular parent-teacher meetings to address any issues, concerns, or parent complaints.
• Providing a pleasant, safe, and sanitary environment.
• Communicating with parents and providing updates on children’s progress.

Requirements:

• High school diploma or GED.
• Proven experience working as a childcare teacher.
• In-depth understanding of childhood development.
• Strong conflict resolution skills.
• Excellent communication skills.
• Attentive and patient.

Responsibilities:

• Handle on stationeries, pantry supplies, and printed materials
• Handling Office Administrative duties and paperwork including accounting data entry
• Work closely with various departments to ensure smooth work flow
• Administer work pass applications, cancellation and renewal.
• Performs day-to-day broad range of HR activities including recruitment from on-boarding to off-boarding, leave administration, MC record, payroll, benefit & training administration.
• Generates and maintain regular HR reports as required.
• Handle NSmen make-up claim, paternity, maternity, childcare leave, medical & insurance claims.
• Handle all other HR matters and undertake tasks as assigned by management.
• Miscellaneous operational and administrative duties.

Requirements:

• Good verbal communication and strong English-language skills
• Meticulous, organized, resourceful and multi-tasker
• A good team player who can work independently
• Proficient in Microsoft Office
• Knowledge of simple accounting will be an added advantage
• Relevant HR work experience preferred.

JOB DESCRIPTION

• Develops and maintains a detailed project schedule which includes administrative tasks and all sites involved in the project.
• File all project documents (soft and hard copies).
• Responsible to track project changes.
• Compile project summary documents.
• Gathers all project information; schedules, data requests,assignments,tasks, and project meetings.
• Process daily,weekly and monthly reporting to ensure all schedules run smoothly, all jobs are completed as prescribed.

QUALIFICATIONS

• Must hold any qualifications / certificates related to Building and Construction.
• Preferably with experience working in Construction Industry.
• Good and Strong Communication Skills.
• With Leadership Skills.
• Ability to work in a fast-paced, intense environment.
• Must be proficient in Microsoft Office.
• Solid organizational skills, including multitasking and time management.
• Strong client-facing and teamwork skills.

JOB DESCRIPTION

• Develops and maintains a detailed project schedule which includes administrative tasks and all sites involved in the project.
• File all project documents (soft and hard copies).
• Responsible to track project changes.
• Compile project summary documents.
• Gathers all project information; schedules, data requests,assignments,tasks, and project meetings.
• Process daily,weekly and monthly reporting to ensure all schedules run smoothly, all jobs are completed as prescribed.

QUALIFICATIONS

• Must hold any qualifications / certificates related to Building and Construction.
• Preferably with experience working in Construction Industry.
• Good and Strong Communication Skills.
• With Leadership Skills.
• Ability to work in a fast-paced, intense environment.
• Must be proficient in Microsoft Office.
• Solid organizational skills, including multitasking and time management.
• Strong client-facing and teamwork skills.

Roles & Responsibilities

A chef is tasked with ensuring the kitchen runs smoothly, preparing food and sauces, and assisting head chefs with service. Candidates for this role need to be comfortable working in a fast-paced and often stressful work environment. They also need passion and enthusiasm for what they do. This is a full-time job and the hours are typically long, with weekend and evening work quite common. Work is usually performed in a well-lit industrial kitchen and in close quarters with colleagues. A role as a lead line cook would suit people who are passionate about cooking, enjoy a challenge, and like working as part of a team.

Skills/Qualifications:

- At least 2 years of relevant experience in food court / institutional catering

- Willing to be involved in hands on operations

- Excellent communication and interpersonal skills

- Able to lead and motivate to produce results

- Ability to work in a fast-paced environment

- Team player

Roles & Responsibilities

A chef is tasked with ensuring the kitchen runs smoothly, preparing food and sauces, and assisting head chefs with service. Candidates for this role need to be comfortable working in a fast-paced and often stressful work environment. They also need passion and enthusiasm for what they do. This is a full-time job and the hours are typically long, with weekend and evening work quite common. Work is usually performed in a well-lit industrial kitchen and in close quarters with colleagues. A role as a lead line cook would suit people who are passionate about cooking, enjoy a challenge, and like working as part of a team.

Skills/Qualifications:

- At least 2 years of relevant experience in food court / institutional catering

- Willing to be involved in hands on operations

- Excellent communication and interpersonal skills

- Able to lead and motivate to produce results

- Ability to work in a fast-paced environment

- Team player

What we do?

Boys’ Town is a charity founded by the Montfort Brothers of St. Gabriel in 1948. Its key services include residential care, fostering service, respite care, youth outreach, adventure therapy and clinical intervention.

Boys’ Town serves both boys and girls, from infants to young adults. It helps children and youth coming from disadvantaged and disengaged families who may have faced hardship due to difficult home situations, financial struggles, abandonment, and abuse. Boys’ Town equips children and youth in need with skills to become socially integrated, responsible, and contributing members of society.

What you will be doing?
To provide Human Resource and administration support to the Human Resource Department and provide quality customer service to both internal and external clients.

Job Responsibilities

Recruitment & Selection

• Assist in recruitment: job postings, pre-screening, phone interviews, shortlisting, coordinating interviews, document verification, interview prep, reference checks, pre-employment medicals, rejection emails.
• Prepare new hire onboarding packs, book induction rooms, send evaluations.
• Arrange, coordinate, and send invites for new hire induction.
• Assist in recruitment strategies like career fairs.
• Update daily hiring and vacancy tracking reports.
• Track and update new hire evaluations monthly.
• Manage voluntary and involuntary terminations, updating monthly reports.

Training & Development

• Manage and update training records.
• Coordinate in-house training: room bookings, attendance sheets.
• Handle training administration: documentation, communication, course applications, liaising with providers, training grants, evaluations.
• Collect data, prepare training evaluation reports for management.
• Support assigned projects: email follow-ups, venue setup, program coordination.
• Track and update the training budget.
• Conduct training as needed.

HR Administration

• Assist in employee engagement and wellbeing programs.
• Update and submit reports as needed.
• Prepare PowerPoint slides for reporting.
• Take minutes when necessary.
• Assist in performance management reviews.
• Track contract renewals and performance appraisals.
• Support corporate governance, audits, compliance, and documentation.
• Generate and track attendance sheets for meetings.
• Support employee welfare: baby hampers, wreaths, etc.
• Handle HR department purchases/requisitions.
• Provide administrative support to the HR Manager/Directors.
• Participate in meetings, committees, and projects as needed.
• Perform other assigned duties.
• Report to and provide feedback to the HR Manager.
• Actively participate in fundraising and other Boys’ Town commitments.
• Collaborate with staff, departments, and components of Boys’ Town.
• Perform additional duties assigned by the Executive Director or representative.

Requirements

• Minimum Diploma in Human Resource Management or equivalent.
• Preferably 1 year of relevant working experience*
• Good understanding of the Employment Act.
• Excellent organizational skills and attention to detail
• Proficient in record keeping (filing/documentation).
• Strong follow-up skills characterized by timeliness, persistence, organization, clear communication, attention to detail, proactiveness, and accountability.
• Good interpersonal and communication skills.
• Initiative and ability to work well in a team.
• Customer service oriented.
• Ability to work quickly and handle pressure effectively.
• Proficient in MS Office (Outlook, Excel, Word, PowerPoint); knowledge in HRMS is a plus.

Why join us?

Joining Boys’ Town means being part of a mission-driven organization where you’ll grow as a professional while giving back to the community.

Be part of something bigger by joining Boys’ Town as a Human Resource Officer. Help us shape a better future for children and youth from different backgrounds, while growing your career in a meaningful way. If you’re passionate about HR and want to contribute to positive change, Boys' Town is the place for you.

Bring your talents to a cause that matters apply now and make a difference with us!

*Candidates with more years of relevant experience may be considered for the role of Senior HR Officer or HR Executive if deemed appropriate and suitable for the role.

Ensure that the production, preparation and presentation of food are of the highest quality

Knowledgeable in terms of standard procedures and policies

Operate and maintAain equipment and reporting of malfunctioning

Controlling of Operation & Food cost whenever necessary

Upkeeping of cleanliness and hygiene standard

Daily feedback collection and report of issues

Any ad-hoc duties as assigned

Requirements:

• Organise and maintain employee P-Files
• Schedule interviews for potential candidates
• Assist in managing staffs’ learning and development needs
• Plan and coordinate activities for staffs’ welfare, training, teambuilding needs
• Standard Operating Procedures (SOPs) and its process flow
• Support any administrative duties required
• Assist in campus recruitment activities which includes intern and management trainee recruitment planning
• Support on the execution of the recruitment cycle of potential candidates for BBP’s internship and scholarship programmes including but not limited to sourcing, screening, and selections
• Liaise with universities, interact with students, and place advertisements to promote our company brand
• Welcoming new employees to the organization, coordinate and conduct orientation sessions.
• Contribute to data entry and analysis for HR metrics and reports.
• Collaborate on HR initiatives and projects, offering your insights and assistance.
• Administering employee benefits, such as health insurance and retirement plans.
• Support exit interviews.

Qualifications:

• Currently pursuing a Bachelor’s degree in Human Resource Management or any related field.
• Able to commit at least 6 months from January - June 2025

Key Responsibilities:

- To support product merchandising and stock replenishment at various locations.

- set up(early morning) and set down (at night) for counter/atrium activities at some period.
- arrange working schedule for promoter.

- Submit picking list to warehouse.
- Ad-hoc duties as assigned.

Requirements

- Relevant work experience is preferred but not necessary.

- Physically fit to support product merchandising and stock replenishment at the stores.

- Able to start work Immediately / short notice.

- 5.5 day work week

Benefits:
- Mobile Phone Allowance

- Transport allowance
- Attractive Commission Scheme
- Annual & Medical Leave Benefits

Summarized Purpose:

• Provides support to investigator sites, monitors, department, business unit or function through communication of information, training sites and documentation of services pertaining to clinical trials. Supports the overall performance, education and training of the sites on a study level to ensure the execution of protocols are completed accurately and on time. Uses the tools provided to answer all questions, takes orders and ensure clean data at the earliest point in time.

Essential Functions:

• Acts as the point of contact for sites, ensuring that questions, material orders and request for information are responded and documented in an accurate and timely manner. Ensures that the sites are properly trained in aspects of the protocol (following the study flow sheet) relating to the department. Provides guidance on pre-analytical aspects of the study to ensure smooth flow of data to and from the site.
• Triages calls where necessary to appropriate individual/departments and follow through to resolution.
• Resolves queries so that efficient and timely sample analysis is undertaken by the laboratory so report turn around time is met. Continually reviews exceptions to resolve so that the data is cleaned within the agreed timelines.
• Notifies the sites and all necessary contacts via telephone/fax of all relevant critical/voice alert values/ study specific requirements.
• Places all calls to the sites delivering sponsor alert, voice alert values (VAV) and any other critical values. Answers incoming phone calls, resolves different types of exceptions within assigned timelines.
• Monitors and escalates site issues through the appropriate departments/people e.g. project management to resolve and report as soon as possible. Ensures that all site issues are communicated and followed up to resolution, primarily to site and monitor. Reviews site performance metrics to educate where needed or to report back to monitor or sponsor. Informs site of the results or reasoning not to proceed.
• Follows the specifications and scope of work to evaluate requests for any additional test(s) (test performed in protocol) to be added to a sample. Evaluates the request for out of protocol testing following Scope of work for study. Facilitates requests to the appropriate person.
• Coordinates and resolves issues with samples at time of scanning to have the samples in the database and reported as soon as possible.

Job Qualification

Education and Experience: 
High / Secondary school diploma or equivalent and relevant formal academic / vocational qualification

Knowledge, Skills and Abilities:

• Mandate to be fluent in Japanese and English langaugese (Speaking, Reading, Writing)
• Accurate data entry skills with intermediate computer skills including Microsoft Office
• Strong analytical, interpersonal and time management skills
• Strong client and phone service skills
• Excellent verbal communications and customer service skills
• Critical thinking and problem solving skills to support quality decision making
• Good written and oral communication skills
• Ability to work in a collaborative team environment

Training will be provided. No prior work experience needed.

Responsibilities:
• Performing the Job of a HR and Admin Assistant.
• Assists Manager/Executive in handling all HR & admin functions eg Payroll, course matters
• Assists in and Ad-Hoc HR/Admin-related matters.
• Any other relevant duties as assigned

Requirements:
• Pro-active attitude, responsive, able to multitask well & eye for details
• Ability to exercise initiative, work independently and under pressure
• Fluent in English
• Able to start work within short notice will be of great advantage
• 5 days’ work week

The Human Resource Executive will assist the HR Manager in executing HR functions related to the recruitment, engagement, performance, development, and retention of talent within the company.

Key Responsibilities:

· Support the HR Manager with administrative tasks throughout the employee life cycle, including recruitment, onboarding, transfers, and terminations.

· Assist in overseeing the talent management framework and performance appraisal processes.

· Collaborate with the HR Manager to develop and implement HR policies and guidelines.

· Help prepare monthly payroll, including the processing of statutory claims and filing of income tax.

· Administer and oversee leave matters and insurance claims.

· Facilitate reporting procedures related to employee discipline and grievances.

· Maintain and update employee movement records and databases.

· Prepare and deliver timely HR data and reports as needed.

· Manage employees’ expense claims.

· Oversee office administration tasks, including seasonal parking, stationery, and pantry supplies.

· Perform additional HR and office administration duties as assigned.

· Familiarity with payroll software, specifically QuickHR, is preferred.

Work Location: Pasir Panjang.

Join Our Thriving HR Team: Senior HR Specialist | HR Generalist | With min. 2 years experience

Are you driven by the excitement of building a talented team and fostering a vibrant work culture? If you have over three years of HR experience, we want to connect with you!

Your Role:

• Source, interview, and onboard top-tier talent.
• Oversee work pass applications and renewals for a flawless onboarding experience.
• Develop and implement training programs to boost employee skills.
• Set performance goals, conduct reviews, and manage employee relations.
• Ensure strict adherence to labor laws and regulations.

What We Need:

• A diploma or degree in HR or a related field.
• Exceptional communication and interpersonal skills.
• Strong organizational and time management capabilities.
• Proficiency in Microsoft Office Suite.

What We Offer:

A competitive salary and benefits package, including health insurance!

Ready to take your HR career to the next level?

Apply now through our website or WhatsApp us at 80353296 or email us at [email protected]

Joy Resources Consultancy is seeking customer-oriented individuals eager to expand their skills in managing a branch independently within a dynamic environment. The Sales Manager position requires CEI qualifications due to its emphasis on detailed knowledge of employment laws and regulations.

Remuneration & Benefits:

• Competitive Basic Salary: S$4,500 to S$6,500
• Lucrative Commission
• Annual Performance Bonus

Requirements:

• Mandatory CEI certification
• Preferred sales experience in the relevant industry
• Strong sales acumen, self-motivated, and capable of sourcing and closing sales autonomously
• Ability to handle all operational aspects of a branch office, including sales, customer support, and rostering
• Effective communication skills
• Positive attitude and a team player

Responsibilities:

• Conduct screening interviews to assess the qualifications and suitability of potential domestic helpers.
• Match families with the most suitable MDW based on their specific needs and preferences.
• Provide ongoing support and guidance to both families and MDWs to foster successful working relationships.
• Stay updated on the latest regulations and best practices in the domestic helper industry.
• Maintain accurate records and documentation.

If you believe you are a suitable candidate for this role, please apply via mycareerfuture website or submit your resume to [email protected]. We look forward to receiving your application.

Understanding the pharmaco/nutrico/toxicokinetic behaviour of drugs, chemicals and food ingredients is a fundamental step in assessing the efficacy and safety of these materials. It can be challenging to study such substances directly in human subjects, while animal models lack direct translatability to humans due to inherent differences in species biology. One promising strategy is the use of physiologically-based pharmacokinetic (PBPK) modelling to predict the local tissue and systemic exposure of these substances. We have developed in-house in vitro and in silico tools to model chemical absorption, distribution, metabolism and excretion (ADME) in humans using data generated from in vitro assays. We apply these tools to predict pharmacokinetic profiles in different settings, ranging from oral or transdermal administration to studying special populations such as pregnant women, for a variety of substances including pharmaceuticals, food ingredients, environmental contaminants, essential micronutrients and microbial metabolites. These capabilities are further enhanced with state-of-the-art, enabling technologies such as the SHIME® intestinal digestion simulator and spatial mass spectrometry imaging.

The following tasks are expected of the candidate:

• Literature search to extract relevant ADME data for chemicals of interest
• Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays
• Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments
• Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals
• Develop new and/or improve features of in-house models, including pharmacodynamic modelling
• Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts
• Supervise and train students and interns

Qualifications

• PhD in Pharmaceutical Science, Life Sciences or equivalent.
• Strong understanding of ADME and pharmacokinetic concepts is essential.
• Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
• Prior experience with PBPK tools such as Simcyp®, GastroplusTM, PK Sim, Matlab/Simbiology or other models is desirable.
• Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Understanding the pharmaco/nutrico/toxicokinetic behaviour of drugs, chemicals and food ingredients is a fundamental step in assessing the efficacy and safety of these materials. It can be challenging to study such substances directly in human subjects, while animal models lack direct translatability to humans due to inherent differences in species biology. One promising strategy is the use of physiologically-based pharmacokinetic (PBPK) modelling to predict the local tissue and systemic exposure of these substances. We have developed in-house in vitro and in silico tools to model chemical absorption, distribution, metabolism and excretion (ADME) in humans using data generated from in vitro assays. We apply these tools to predict pharmacokinetic profiles in different settings, ranging from oral or transdermal administration to studying special populations such as pregnant women, for a variety of substances including pharmaceuticals, food ingredients, environmental contaminants, essential micronutrients and microbial metabolites. These capabilities are further enhanced with state-of-the-art, enabling technologies such as the SHIME® intestinal digestion simulator and spatial mass spectrometry imaging.

The following tasks are expected of the candidate:

• Literature search to extract relevant ADME data for chemicals of interest
• Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays
• Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments
• Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals
• Develop new and/or improve features of in-house models, including pharmacodynamic modelling
• Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts
• Supervise and train students and interns

Qualifications

• PhD in Pharmaceutical Science, Life Sciences or equivalent.
• Strong understanding of ADME and pharmacokinetic concepts is essential.
• Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
• Prior experience with PBPK tools such as Simcyp®, GastroplusTM, PK Sim, Matlab/Simbiology or other models is desirable.
• Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.