We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to study the metabolic regulation of immune cells during the NASH to NASH-HCC progression.

Metabolic regulation of immune dysfunction during the progression of NASH to NASH-HCC

Description:

The lack of effective treatments for non-alcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma (NASH-HCC) underscores the need to understand the transition from NASH to NASH-HCC. Identifying why some NASH patients develop HCC while others do not is a significant challenge, with growing evidence indicating that immune dysregulation plays a crucial role in this progression. The interstitial space, where cells receive nutrients and signals, significantly impacts immune function, suggesting that understanding the liver"s metabolic environment could reveal how immune cells behave during NASH progression to HCC. By profiling interstitial fluid metabolism and single-cell transcriptomics, the team aims to understand the metabolic regulation of the immune landscape in NASH to NASH-HCC progression. Using a high-fat, high-fructose, and high-cholesterol dietary mouse model that mirrors human progression, the team will study the metabolic and immune changes leading to NASH-HCC. In addition, the team’s preliminary findings show immune alterations and reduced levels of the bile acid hyodeoxycholic acid (HDCA) during NASH-HCC transition. The identified candidate will also test the potential of HDCA in preventing NASH to HCC transition, and further explore HDCA"s effects on immune cells.

Job responsibilities:

• Conduct in vitro wet lab experiments (e.g. cell culture, molecular biology and assays, microscopy etc)
• Conduct in vivo animal experiments (e.g. diet/treatment regimes, body weight & composition analyses, metabolic phenotyping, blood sampling etc)
• Conduct end-point animal experiments (e.g. terminal blood collection, tissue collection and sample preparation, whole tissue/organ imaging, serum measurements etc)
• Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings
• Interact and collaborate with and assist other researchers and collaborators on related projects
• Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction
• Assist in the preparation of grant applications and grant process reports
• Present findings both orally and in written form via presentations and publication in peer-reviewed journal
• Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals
• Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to identify and validate candidates that address the body’s adaptive responses to weight loss.

TaRgeted Analysis of Novel Secreted Factors for Obesity Reduction and Metabolic Health (TRANSFORM)

Description:

Multi-omic analysis of secreted factors from various datasets was carried out, including human, mouse and primate plasma and metabolic tissues to identify novel primate-specific secreted factors critically involved in the regulation of physiology balance. Integrative data analysis and in silico rank scoring revealed a list of promising secreted factor candidates. We will be using model organisms (e.g. mice, zebrafish) to conduct phenotypic screens and prioritize candidates for detailed validation, characterization, mode-of-action studies and therapeutic strategies.

Job responsibilities:

● Conduct in vitro wet lab experiments for identified candidates (e.g. cell culture, molecular biology and assays, protein chemistry, pharmacological efficacy etc)

● Conduct in vivo screening experiments for prioritized candidates (e.g. in preclinical models of obesity)

● Conduct end-point and mechanistic experiments (e.g. target tissue and blood collection, sample preparation etc)

● Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings

● Interact and collaborate with and assist other researchers and collaborators on related projects

● Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction

● Assist in the preparation of grant applications and grant process reports

● Present findings both orally and in written form via presentations and publication in peer-reviewed journal

● Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals

● Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

Recipient of the esteemed International Translational Neuroscience Award, Dr. Yan, a pioneer in Brain Tumor research, joins IMCB to establish the NeuroPhenomics Lab. This lab marks a new chapter in our quest for profound biological insights and their translation into biomarkers and therapies.

The labs mission revolves around a profound exploration of brain tumor biology, particularly focusing on key driver mutations like IDH1 and IDH2. These mutations, significant in the development of aggressive malignant gliomas, are pivotal in altering chromatin and genome methylation, thus influencing tumor evolution. The lab extends this research by identifying other genetic alterations with potential clinical relevance.

Dedicated to exploring new frontiers, the NeuroPhenomics Lab integrates advanced techniques in genetics, epigenetics, and metabolomics at both single-cell and spatial levels. This approach allows for a detailed examination of tumor cell diversity and their interactions within the microenvironment. The lab also investigates neurometabolism, emphasizing the TCA cycle and IDH enzymes, and studies how metabolites affect the brain and tumor progression.

Aiming to bridge research and clinical application, the lab"s multi-dimensional strategy includes iPSCs, patient-derived organoids, transgenic models, and advanced imaging technologies. This positions the NeuroPhenomics Lab at the forefront of developing transformative therapies in neurooncology and neurometabolism.

Key Qualifications:

• Ph.D. with experienced individuals in a related field, with a research focus.
• Experience in any of the following areas:
  • Cancer Biology or Cancer Immunology
  • Single-cell sequencing and spatial-omics data
  • Computational structural biology and protein design
  • Developing generative AI models
  • Computer-aided drug discovery
• Exceptional analytical, technical, and problem-solving skills
• Ability to work independently and thrive in a dynamic team environment

We look forward to welcoming you to our team and driving forward groundbreaking research in brain tumor genomics.

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

A Research Officer position is immediately available at the Stem Cells and Diabetes Laboratory. Dr Adrian Teo's laboratory is interested in leveraging on stem cell technology to study mechanisms underlying diabetes and metabolic diseases. Reference: www.adrianteolab.com.

Qualifications / Requirements:

• Degree in Biological Science and Life Science disciplines or equivalent
• Deep commitment and interest in research, demonstrated from previous research experience
• Minimum 6 months prior research experience in the Biomedical field
• Experience with mammalian cell culture and molecular biology techniques
• Experience with animal work and surgical techniques
• Experience with mammalian stem cell work will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work and able to work flexible hours
• Ability to multitask, work independently and also as part of a team
• Excellent communication (verbal and written) and presentation skills
• Experience in Flow Cytometry, Immunoprecipitation techniques, RNA-seq, Mass Spectrometry and bioinformatics will be valued

Interested candidates are invited to send a brief cover letter detailing research motivation, curriculum vitae, and the names and email addresses of referees.

Responsibilities

The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated Scientist or Senior Scientist to join a team developing a ribozyme-based RNA platform for potential translational and/or clinical applications.

The work will involve both in vitro and in vivo techniques, including molecular biology (RNA design, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology (cell culture, cell transfection, flow cytometry, antisense oligonucleotides and RNAi, CRISPR), high-resolution imaging techniques, and experiments in mouse models (e.g. transgenesis, in situ hybridization and immunohistochemistry, imaging and functional analyses)

Requirements

• Minimum Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Genetics, Neuroscience or a related discipline.
• The successful candidate should have strong expertise in RNA biology, cell biology, biochemistry and molecular biology techniques, a strong publication record that includes a first author research paper, and strong scientific writing skills.
• They should be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary, and the successful candidate should be able to work effectively and harmoniously in a diverse team.
• As a Scientist, candidate will also be expected to mentor and train students and Research Officers.

Recipient of the esteemed International Translational Neuroscience Award, Dr. Yan, a pioneer in Brain Tumor research, joins IMCB to establish the NeuroPhenomics Lab. This lab marks a new chapter in our quest for profound biological insights and their translation into biomarkers and therapies.

The lab"s mission revolves around a profound exploration of brain tumor biology, particularly focusing on key driver mutations like IDH1 and IDH2. These mutations, significant in the development of aggressive malignant gliomas, are pivotal in altering chromatin and genome methylation, thus influencing tumor evolution. The lab extends this research by identifying other genetic alterations with potential clinical relevance.

Dedicated to exploring new frontiers, the NeuroPhenomics Lab integrates advanced techniques in genetics, epigenetics, and metabolomics at both single-cell and spatial levels. This approach allows for a detailed examination of tumor cell diversity and their interactions within the microenvironment. The lab also investigates neurometabolism, emphasizing the TCA cycle and IDH enzymes, and studies how metabolites affect the brain and tumor progression.

Aiming to bridge research and clinical application, the lab"s multi-dimensional strategy includes iPSCs, patient-derived organoids, transgenic models, and advanced imaging technologies. This positions the NeuroPhenomics Lab at the forefront of developing transformative therapies in neurooncology and neurometabolism.

Key Qualifications:

• Ph.D. with experienced individuals in a related field, with a research focus.
• Experience in any of the following areas:
  • Cancer Biology or Cancer Immunology
  • Single-cell sequencing and spatial-omics data
  • Computational structural biology and protein design
  • Developing generative AI models
  • Computer-aided drug discovery
• Exceptional analytical, technical, and problem-solving skills
• Ability to work independently and thrive in a dynamic team environment

We look forward to welcoming you to our team and driving forward groundbreaking research in brain tumor genomics.

Responsibilities

The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated Scientist or Senior Scientist to join a team developing a ribozyme-based RNA platform for potential translational and/or clinical applications.

The work will involve both in vitro and in vivo techniques, including molecular biology (RNA design, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology (cell culture, cell transfection, flow cytometry, antisense oligonucleotides and RNAi, CRISPR), high-resolution imaging techniques, and experiments in mouse models (e.g. transgenesis, in situ hybridization and immunohistochemistry, imaging and functional analyses)

Requirements

• Minimum Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Genetics, Neuroscience or a related discipline.
• The successful candidate should have strong expertise in RNA biology, cell biology, biochemistry and molecular biology techniques, a strong publication record that includes a first author research paper, and strong scientific writing skills.
• They should be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary, and the successful candidate should be able to work effectively and harmoniously in a diverse team.
• As a Scientist, candidate will also be expected to mentor and train students and Research Officers.

Job Title: Chemist (Environmental)

1. Perform lab test on environmental samples and reporting of test data
2. Supervise junior analysts in routine sample analysis to ensure accurate and reliable analytical results
3. Responsible for quality control, instrument troubleshooting and training
4. To prepare and upkeep quality system as per SAC-Singlas requirement
5. Ensure proper equipment performance and test data reliability by carrying out routine QAQC protocols and scheduled Preventive Maintenance as needed
6. Involve in planning and work distribution
7. Maintain good relationship with client, support after office hour activation if required.
8. Other ad-hoc duties as assigned

Postdoctoral Scientist position

A postdoctoral scientist position is available immediately in the laboratory of Dr. Leslie Beh at IMCB.

The Beh lab seeks to develop cutting-edge CRISPR-Cas technologies to uncover the biological functions of RNA modifications. Dysregulation of these modifications has been linked to cancer, neurological disorders, and metabolic disease. We will determine the mechanisms by which RNA modifications and CRISPR-Cas systems operate by drawing upon diverse techniques, including protein engineering, biochemical reconstitution, genomics, and cell-based experiments. Successful applicants can expect close mentorship in a collaborative environment, with an emphasis on developing scientific knowledge and individual career goals. More information about can be found at (https://www.behlab.org/).

Requirements:

• Ph.D. in Life Sciences / Biomedical Sciences
• Experience in biochemistry and/or structural biology, particularly in protein-RNA or protein-DNA interactions.
• in vitro reconstitution of enzymatic activity using cell extracts or purified proteins
• Recombinant protein purification from bacterial and insect cells
• Genuine interest in pursuing a research-based career.
• Strong work ethic, with excellent organizational and communication skills

Preferred experience:

• Mammalian cell culture
• NGS library generation and data analysis
• Prior roles in lab management

Postdoctoral Scientist position

A postdoctoral scientist position is available immediately in the laboratory of Dr. Leslie Beh at IMCB.

The Beh lab seeks to develop cutting-edge CRISPR-Cas technologies to uncover the biological functions of RNA modifications. Dysregulation of these modifications has been linked to cancer, neurological disorders, and metabolic disease. We will determine the mechanisms by which RNA modifications and CRISPR-Cas systems operate by drawing upon diverse techniques, including protein engineering, biochemical reconstitution, genomics, and cell-based experiments. Successful applicants can expect close mentorship in a collaborative environment, with an emphasis on developing scientific knowledge and individual career goals. More information about can be found at (https://www.behlab.org/).

Requirements:

• Ph.D. in Life Sciences / Biomedical Sciences
• Experience in biochemistry and/or structural biology, particularly in protein-RNA or protein-DNA interactions.
• in vitro reconstitution of enzymatic activity using cell extracts or purified proteins
• Recombinant protein purification from bacterial and insect cells
• Genuine interest in pursuing a research-based career.
• Strong work ethic, with excellent organizational and communication skills

Preferred experience:

• Mammalian cell culture
• NGS library generation and data analysis
• Prior roles in lab management

We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.

Job Description:

The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the suppression by the tumor microenvironment.

Job Requirement:

• PhD in Immunology or Cell Biology
• Possess at least a minimum of 5 years relevant work experience
• Substantial background and publication records in cancer immunology, particularly on T and NK cells
• Experience working with patient-derived samples and experimental models
• Good organisational, verbal and interpersonal skills
• Exhibit ability in mentoring and leading the project

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Duties and Responsibilities - Process Integration

• Plan the integration flow with device designers
• Draft the runsheet by translating the flow into process steps and capturing necessary shortloops
• Perform the DoE with process module teams
• Track the lot and report the progress
• Identify failure modes/root causes and address the problems by proposing changes
• Must be good at documentation and written communication

Job Requirements

• Bachelor's degree in Microelectronics, Electrical, Mechanical, or Chemical Engineering.
• A basic understanding of the semiconductor processes is preferred.
• 3-5 years of hands-on experience in semiconductor processes (Diffusion, Wet Clean, CMP, ECP, Litho, Etch, CVD, PVD, etc.) will add advantages.
• Must be a team worker with the project stakeholders (device design, process module, and equipment/facility).

A Research Officer position is available in Dr. Anand Andiappan Lab at the Singapore Immunology Network (SIgN). The RO position is to support the research work of the team that focuses on studying the role of immune system in eczema and allergies. The candidate will work on primary cells from cohorts and cell culture systems towards understanding immune pathophysiology of disease. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by confocal microscopy, and associated data analysis with statistical tested.

Job Duties:

• Managing safety in the lab
• Creating SOPs and lab risk assessments
• Maintaining lab inventories
• Perform other lab administrative duties and operations such as ordering and tracking lab budget
• Experience with human and mouse blood/tissue sample handling and processing (e.g. isolation of specific immune cell population) and knowledge of immune cell biology is encouraged
• Experience with flow cytometry analysis for different immune cell population and functional immune assays will be an advantage

Job Requirements:

• Degree in Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in molecular biology techniques, immunology, cancer cell biology, cell culture and flow cytometry
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills
• Candidates are expected to be highly motivated to work in research and able to perform tasks independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A Research Officer position is available in Dr. Anand Andiappan Lab at the Singapore Immunology Network (SIgN). The RO position is to support the research work of the team that focuses on studying the role of immune system in eczema and allergies. The candidate will work on primary cells from cohorts and cell culture systems towards understanding immune pathophysiology of disease. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by confocal microscopy, and associated data analysis with statistical tested.

Job Duties:

• Managing safety in the lab
• Creating SOPs and lab risk assessments
• Maintaining lab inventories
• Perform other lab administrative duties and operations such as ordering and tracking lab budget
• Experience with human and mouse blood/tissue sample handling and processing (e.g. isolation of specific immune cell population) and knowledge of immune cell biology is encouraged
• Experience with flow cytometry analysis for different immune cell population and functional immune assays will be an advantage

Job Requirements:

• Degree in Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with at least 5 years experience in molecular biology techniques, immunology, cancer cell biology, cell culture and flow cytometry
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills
• Candidates are expected to be highly motivated to work in research and able to perform tasks independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are seeking to recruit a highly motivated Research Fellow/Research Scientist to support the institute’s overall Research and Innovation goals.

Job Description:

The Research Fellow/Research Scientist will be responsible for engineering novel CAR-NK cells with superior anti-tumor efficacy, enhanced tumor infiltration, and excellent resilience against the suppression by the tumor microenvironment.

Job Requirement:

• PhD in Immunology or Cell Biology
• Possess at least a minimum of 2 years relevant work experience
• Substantial background and publication records in cancer immunology, particularly on T and NK cells
• Experience working with patient-derived samples and experimental models
• Good organisational, verbal and interpersonal skills
• Exhibit ability in mentoring and leading the project

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Contract Period:

• 24 Months - 1 Jan 2025 to 31 Dec 2026

Deployment:

• Mondays to Thursdays: 7:00am to 4:30pm, inclusive of 1hr lunch break
• Fridays: 7:00am to 4:00pm, inclusive of 1hr lunch break (Tentative working hours, subjected to change based on school time table)
• Service not required on Saturdays, Sundays and gazetted public holidays

Scope of Works:

1. Safety in Food Labs

• Assist teachers with the general safety in the food lab i.e. clean up spills on the floor immediately to prevent slips and falls
• Assist teachers with simple first aid treaments such as cuts and burns

2. Receiving food order

• Receive food items ordered by teachers and check the food items against the delivery order
• Pack other food items with appropriate materials and put in the correct storage areas in the food lab
• Keep teachers informed if food items delivered are not in correct quantity or in unacceptable condition.
• Check for food expiry dates and inform teachers accordingly

3. Before and After Practical Lessons of FCE and NFS

• Wipe teachers’ working tables and demonstration table every morning before lessons.
• Clean and maintain the food lab equipment and room after lessons everyday
• Prepare food items and materials needed for practical lessons
• Wash linens that are used for lessons
• Dispose of kitchen refuse from the rubbish bin and lined the bin with trash bag in both labs after practical lessons.

4. Duties during school holidays and events

• Clean and maintain the lab inventory and equipment, report any defects to materials.
• Maintain equipment and utensils of workstations in both Food Laboratories during school holidays and special events

Contract Period:

• 2 Jan 2025 to 31 Dec 2025 (12 Months) + 1 Year Optional renewal by school.

Deployment:

• Mondays to Fridays: 8.30am to 2:00pm, inclusive of 0.5hr lunch break
• Service not required on Saturdays, Sundays and gazetted public holidays

Scope of Works:

1. Assist teachers in the preparation of teaching and learning resources and specimens needed.
2. Assist in the preparation of resources for science practical examinations.
3. Maintain all live specimens and laboratory equipment.
4. Conduct periodic stock-taking on laboratory supplies in science laboratory and advise Science HOD / LH on stock level
5. Conduct daily cleaning of the Life Science and Physical Science laboratories.

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in dermatology, immunology, molecular allergy and clinical immunology
• At least 2 years experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with at least 5 years experience in dermatology, immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A highly motivated postdoctoral research fellow is sought for Dr. Sampath’s laboratory in A*STAR Skin Research Labs, Singapore. This group focuses on exploring and developing RNA therapeutics for various epithelial disorders, including proinflammatory skin conditions and cancer. Delineating the underlying molecular mechanisms and visualizing these interactions, the objective is to identify specific targets and develop targeted therapeutics.

Key Responsibilities:

The successful candidate will work on a couple of these projects, which involves 1. Design and development of an innovative strategy (RNAi-based) for therapeutic intervention of the target gene. 2. Evaluate the efficacy of the pharmaceutical composition by in-vitro assays, ex vivo and in vivo model systems.

Job Requirements:

• PhD in Cell Biology or Molecular Biology
• At least one first-author publication in an international peer-reviewed journal
• Experience in RNA work advantageous
• Highly motivated.
• Willingness and ability to develop new skills.
• Excellent oral, written communication and organizational skills.
• Ability to work independently as well as collaboratively in a team environment.

Host Pathogen Interactions Lab in A*STAR Infectious Diseases Labs (A*STAR IDL) is actively seeking a Scientist to join our mission of becoming a leading center for infectious diseases research. A*STAR IDL is dedicated to advancing translational research in infectious diseases to improve both health and economic outcomes.

Job Description:

We are seeking a talented researcher to lead the research on a 3 year funded research project as well as develop novel ideas in the broad scope of host-pathogen interactions and infectious diseases. Preliminary data gathered will help develop the researcher’s career and path to independence through the various early-career support available internally in A*STAR as well as in the Singapore ecosystem.

The funded project will aim to characterize and compare host-alphavirus interactions at the immune response level in vivo in animal models through a novel viral-centric approach. Preliminary data of the lab has shown a differential adaptive immune response polarization between two alphaviruses and identified, via in vivo comparative multiOmic approaches, a set of candidate host factors potentially responsible for the phenotype. The project will entail a close characterization of these host factors and their role in the viral life cycle as well as the modulation of the immune response of small animal model to these viruses. In addition to multi-Omics approaches (including single-cell and spatial), protein-protein interactions, microscopy, functional genomics, viral reverse genetics and CRISPR Cas9 gene editing will be some of the tools used to investigate this viral hijacking and understand the host-viral interplay. Animals models available in the lab include mice and zebrafish. Downstream of characterization will aim to validate these targets in small preclinical models for subsequent drug discovery in the A*STAR ecosystem. Throughout the project, close collaborative work within A*STAR IDL as well as other institutes throughout Singapore and overseas will be used to leverage expertise for high impact studies.

Job Requirements

• PhD in Biomedical Sciences, Life Sciences, Immunology or related field
• Atleast 2 years of relevant experience in immunology or related field. No virology experience necessary.
• Highly motivated and able to work independently.
• Team player with good interpersonal skills.
• Good spoken and written communication skills.
• Familiar with bioinformatics
• Willing to learn to work in a BSL3 facility if necessary
• Must be comfortable to work with small animal models.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Host Pathogen Interactions Lab in A*STAR Infectious Diseases Labs (A*STAR IDL) is actively seeking a Scientist to join our mission of becoming a leading center for infectious diseases research. A*STAR IDL is dedicated to advancing translational research in infectious diseases to improve both health and economic outcomes.

Job Description:

We are seeking a talented researcher to lead the research on a 3 year funded research project as well as develop novel ideas in the broad scope of host-pathogen interactions and infectious diseases. Preliminary data gathered will help develop the researcher’s career and path to independence through the various early-career support available internally in A*STAR as well as in the Singapore ecosystem.

The funded project will aim to characterize and compare host-alphavirus interactions at the immune response level in vivo in animal models through a novel viral-centric approach. Preliminary data of the lab has shown a differential adaptive immune response polarization between two alphaviruses and identified, via in vivo comparative multiOmic approaches, a set of candidate host factors potentially responsible for the phenotype. The project will entail a close characterization of these host factors and their role in the viral life cycle as well as the modulation of the immune response of small animal model to these viruses. In addition to multi-Omics approaches (including single-cell and spatial), protein-protein interactions, microscopy, functional genomics, viral reverse genetics and CRISPR Cas9 gene editing will be some of the tools used to investigate this viral hijacking and understand the host-viral interplay. Animals models available in the lab include mice and zebrafish. Downstream of characterization will aim to validate these targets in small preclinical models for subsequent drug discovery in the A*STAR ecosystem. Throughout the project, close collaborative work within A*STAR IDL as well as other institutes throughout Singapore and overseas will be used to leverage expertise for high impact studies.

Job Requirements

• PhD in Biomedical Sciences, Life Sciences, Immunology or related field
• At least 4 years of relevant experience in immunology or related field. No virology experience necessary.
• Highly motivated and able to work independently.
• Team player with good interpersonal skills.
• Good spoken and written communication skills.
• Familiar with bioinformatics
• Willing to learn to work in a BSL3 facility if necessary
• Must be comfortable to work with small animal models.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

A highly motivated postdoctoral research fellow is sought for Dr. Sampath’s laboratory in A*STAR Skin Research Labs, Singapore. This group focuses on exploring and developing RNA therapeutics for various epithelial disorders, including proinflammatory skin conditions and cancer. Delineating the underlying molecular mechanisms and visualizing these interactions, the objective is to identify specific targets and develop targeted therapeutics.

Key Responsibilities:

The successful candidate will work on a couple of these projects, which involves 1. Design and development of an innovative strategy (RNAi-based) for therapeutic intervention of the target gene. 2. Evaluate the efficacy of the pharmaceutical composition by in-vitro assays, ex vivo and in vivo model systems.

Job Requirements:

• PhD in Cell Biology or Molecular Biology
• At least one first-author publication in an international peer-reviewed journal
• Experience in RNA work advantageous.
• Highly motivated.
• Willingness and ability to develop new skills.
• Excellent oral, written communication and organizational skills.
• Ability to work independently as well as collaboratively in a team environment.