The Singapore Immunology Network (SIgN), A*STAR, is seeking to appoint an outstanding Senior Principal Scientist to carry out internationally competitive research in Autoimmunity and Inflammatory Diseases.

The research should investigate the pathophysiology of biological pathways and novel pathogenic mechanisms for debilitating disorders, with the aim to translate insights into innovative therapeutic approaches that lead to significant clinical benefits.

The successful candidate is expected to build and maintain a strong research programme that complements the existing programmes at SIgN, and to establish collaborations with the biomedical community and industry. The candidate will also mentor Junior PIs, postdocs and PhD students.

The Senior Principal Scientist position is equivalent to that of an Associate/Full Professor in the university system. The successful candidate can look forward to a competitive salary package and resources as well as a dynamic work environment. Although part of the research programme will be supported by core funding, the candidate is expected to expand his/her research activities by securing additional funds through the various grant schemes available in Singapore and abroad.

Job Responsibilities:

• To lead a research team to conduct experimental research in the areas of Autoimmunity and Inflammatory Diseases.
• To initiate and execute novel research projects, to translate research outputs into clinical or industrial collaborations
• To write up high impact research publications
• To mentor and provide support to junior researchers

Job Requirements:

• PhD in Immunology, Microbiology, Biomedical Sciences, or other relevant disciplines
• More than 10 years’ experience in independent research and leading a research group
• Strong lab-based research background in Immunology and Microbiology
• An excellent track record of research publications
• Excellent written and spoken communication skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Essential duties and responsibilities for this position include:

• The candidate will work together with a multidisciplinary research team to develop the quantum optical characterization setups, such as g(2) measurements, entangled photon measurements
• Optical characterizations of the fabricated quantum optical & nanophotonic devices.
• Data processing, programming, and automation of characterization setups
• Scientific dissemination (journal papers, conferences, and patents)

The detailed job requirements:

• A PhD Degree in physics/quantum optical characterization
• Strong publication track record
• Strong foundation knowledge in quantum optical characterization.
• Strong capability with optical alignment and optical characterization is an essential requirement.
• Self-motivated and passionate on research work
• Possess good critical thinking and problem-solving skills
• Good team player
• Excellent oral and written communication skills
• Applicants with no minimum work experience may apply

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

About EDDC EDDC is a national platform committed to developing innovative therapies that have the potential to transform patients" lives. Our research and development efforts are focused on understanding the underlying mechanisms of disease and translating these insights into effective treatments. We collaborate with both public sector and industry partners to translate scientific discoveries in Singapore’s biomedical and clinical research into innovative healthcare solutions.

Position Summary

We are seeking a highly motivated Junior Scientist/Scientist I to join our dynamic research team. The ideal candidate will have a strong foundation in chemical biology and thrive in an interdisciplinary research environment. The successful candidate will contribute to cutting-edge research focused on the design, synthesis, and application of small molecule probes for target engagement studies aimed at understanding disease mechanisms and advancing drug discovery.

Job Description

• Plan and execute research experiments under supervision and communicate results and conclusions in group meetings.
• Contribute to ongoing research and development projects in a fast-paced, collaborative environment.
• Maintain detailed and accurate lab notebooks to document research findings.
• Ensure proper upkeep of lab equipment, laboratory supplies, and maintain good housekeeping standards.

Job Qualifications

• A BSc in Chemical Biology is preferred. Applicants with a BSc in Chemistry, Biology, or related disciplines with relevant skill sets may also be considered.

Job Requirements

• Chemistry lab skills: Proficient in the synthesis and purification of compounds (using flash column chromatography, preparative HPLC), and compound characterization techniques (LCMS, HPLC, NMR).
• Biology lab skills: Proficient in cell culture, SDS-PAGE, Western Blot, pulldown and co-immunoprecipitation assays.
• Chemical Biology lab skills: Experience with Activity-Based Protein Profiling (ABPP), Affinity-Based Protein Profiling (AfBP), and chemoproteomics is a plus.
• Candidates without prior experience but with a strong desire and commitment to learn are also encouraged to apply.
• Passion for interdisciplinary research.
• A committed, self-motivated individual with a desire to learn new skills and take on new responsibilities.
• Excellent written and verbal communication skills.
• Strong interpersonal skills, team-oriented with a collaborative spirit and the ability to build relationships internally and externally.

The role will be part of the Singapore Aerospace Programme (SAP) team to manage research projects performed by A*STAR Research Entities for industry partners, manage programme activities and handle industry engagement activites.

Key responsibilities include:

Programme management

• Assist in the planning and execution of new project launches including the call for problem statements, workshops and proposal/technical reviews
• Monitor on-going projects through regular review meetings with research teams to ensure budget and deliverables are met
• Manage report submissions and variation requests
• Assist in the planning and execution of 6-monthly Programme Management Committee (PMC) meetings
• Work with teammates to ensure the smooth operations of the programme
• Support other office functions, e.g. hosting industry events

Stakeholder engagement and development

• Participate in meetings with SAP consortium members, industry stakeholders and public agencies
• Assist in the planning and execution of Singapore Airshow exhibition and hosting of Singapore Aerospace Technology Leadership Forum
• Facilitate the conceptualization and development of follow-on research initiatives beyond SAP
• Work with inter-division or inter-agency teams to drive aerospace industry development, develop industry transformation maps and aerospace roadmaps
• Coordinate industry engagement activities such as company visits to A*STAR and Airshow meetings and manage follow-up actions
• Nurture industry accounts to deepen research activities with A*STAR
• Engage Institutes of Higher Learning (IHLs) to jointly develop research ecosystem aerospace capabilities

Job Requirements

• Bachelor of Engineering, preferably in the field of aerospace or aeronautical
• 8 years of relevant experience, preferably in aerospace MRO or R&D and/or project management roles
• Strong communication skills
• Strong interpersonal skills
• Strong planning and analytical skills
• Result-oriented, resourceful and attentive to details
• Familiarity with the Singapore research ecosystem and grant call process will be an advantage

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The role will be part of the Singapore Aerospace Programme (SAP) team to manage research projects performed by A*STAR Research Entities for industry partners, manage programme activities and handle industry engagement activites.

Key responsibilities include:

Programme management

• Assist in the planning and execution of new project launches including the call for problem statements, workshops and proposal/technical reviews
• Monitor on-going projects through regular review meetings with research teams to ensure budget and deliverables are met
• Manage report submissions and variation requests
• Assist in the planning and execution of 6-monthly Programme Management Committee (PMC) meetings
• Work with teammates to ensure the smooth operations of the programme
• Support other office functions, e.g. hosting industry events

Stakeholder engagement and development

• Participate in meetings with SAP consortium members, industry stakeholders and public agencies
• Assist in the planning and execution of Singapore Airshow exhibition and hosting of Singapore Aerospace Technology Leadership Forum
• Facilitate the conceptualization and development of follow-on research initiatives beyond SAP
• Work with inter-division or inter-agency teams to drive aerospace industry development, develop industry transformation maps and aerospace roadmaps
• Coordinate industry engagement activities such as company visits to A*STAR and Airshow meetings and manage follow-up actions
• Nurture industry accounts to deepen research activities with A*STAR
• Engage Institutes of Higher Learning (IHLs) to jointly develop research ecosystem aerospace capabilities

Job Requirements

• Bachelor of Engineering, preferably in the field of aerospace or aeronautical
• 5 years of relevant experience, preferably in aerospace MRO or R&D and/or project management roles
• Strong communication skills
• Strong interpersonal skills
• Strong planning and analytical skills
• Result-oriented, resourceful and attentive to details
• Familiarity with the Singapore research ecosystem and grant call process will be an advantage

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to study the metabolic regulation of immune cells during the NASH to NASH-HCC progression.

Metabolic regulation of immune dysfunction during the progression of NASH to NASH-HCC

Description:

The lack of effective treatments for non-alcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma (NASH-HCC) underscores the need to understand the transition from NASH to NASH-HCC. Identifying why some NASH patients develop HCC while others do not is a significant challenge, with growing evidence indicating that immune dysregulation plays a crucial role in this progression. The interstitial space, where cells receive nutrients and signals, significantly impacts immune function, suggesting that understanding the liver"s metabolic environment could reveal how immune cells behave during NASH progression to HCC. By profiling interstitial fluid metabolism and single-cell transcriptomics, the team aims to understand the metabolic regulation of the immune landscape in NASH to NASH-HCC progression. Using a high-fat, high-fructose, and high-cholesterol dietary mouse model that mirrors human progression, the team will study the metabolic and immune changes leading to NASH-HCC. In addition, the team’s preliminary findings show immune alterations and reduced levels of the bile acid hyodeoxycholic acid (HDCA) during NASH-HCC transition. The identified candidate will also test the potential of HDCA in preventing NASH to HCC transition, and further explore HDCA"s effects on immune cells.

Job responsibilities:

• Conduct in vitro wet lab experiments (e.g. cell culture, molecular biology and assays, microscopy etc)
• Conduct in vivo animal experiments (e.g. diet/treatment regimes, body weight & composition analyses, metabolic phenotyping, blood sampling etc)
• Conduct end-point animal experiments (e.g. terminal blood collection, tissue collection and sample preparation, whole tissue/organ imaging, serum measurements etc)
• Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings
• Interact and collaborate with and assist other researchers and collaborators on related projects
• Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction
• Assist in the preparation of grant applications and grant process reports
• Present findings both orally and in written form via presentations and publication in peer-reviewed journal
• Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals
• Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in dermatology, immunology, molecular allergy and clinical immunology
• At least 2 years experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Requirements:

• 1-2 years of experience in IOS/Android App development.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Flutter, React, Dart and native programming language.
• Proven experience in building mobile applications for Android and iOS.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are seeking a passionate and skilled Flutter Developer to join our dynamic team. The ideal candidate will have a strong understanding of Flutter development, be proficient in Dart programming, and have experience building high-quality, scalable mobile applications.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications using Flutter.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Job Requirements:

• At least 2 years relevant experience in Flutter development. Candidates with no experience and possess relevant technical knowledge may apply.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Dart programming language.
• Proven experience in building mobile applications for Android and iOS using Flutter.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description:

• Support procurement process at DxD Hub, ensuring technical and policy compliance as well as value-for-money.
• Structuring requirements for procurement process: Translate purchase requests from technical team to online procurement systems.
• Perform and/or support activities throughout procurement process. Example activities include creating internal approval memos and justification, preparing external documents (e.g. Invitation to Quote, Tenders).
• Support proposal evaluation: work with users to perform structured assessment of vendor proposals and recommend proposal to award.
• Partner with executives in other functions including Procurement and Finance to ensure efficient operations.
• Collate and track data to support analysis, including maintaining databases and hard copy records.
• Ensure that database is updated in a timely and accurate manner.
• Provide general administrative and clerical support to DxD Hub Team ensuring safe and comfortable DxD Hub operations.
• General administrative and clerical support to DxD Hub Team.
• Manage and monitor inventory of office and pantry supplies and re-order as needed.
• Track non-scientific equipment and assets (e.g. video conferencing system, furniture) and work with vendors for maintenance.
• Monitor facilities vendors (e.g. cleaning, telecom) to ensure a comfortable office environment for staff including light clean-up as needed.
• Work closely with SpIA and HR for the issuance of staff card for new hires and ensure that the staff has access to all DxD office sites.

Job Requirements:

• Diploma holder with a certificate in professional secretarial skills/ finance.
• Minimum 5 years of relevant experience in similar capacity.
• Experience in purchasing of biomedical consumables and equipment would be an advantage.
• Proficient in MS Office Applications, including Word, Excel, PowerPoint, and Outlook.
• A team player with excellent interpersonal, communication and organisational skills.
• Able to communicate effectively, multi-task, and work in a dynamic environment.
• Well organised and good written communication skills.
• Awareness of workplace health and safety would be an advantage.
• Meticulous and able to work independently in a fast-paced environment.
• Individual who is self-motivated, and results driven.
• Proactive and takes ownership of projects.
• Adaptable and able to work under pressure.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Key Responsibilities:

• Provide scientific and technical expertise to lead a research team to develop capabilities in ingredient fermentation
• Develop mechanistic understanding of the microbiology of fermentation
• Develop research proposals and seek research fundings
• Disseminate research findings through conference presentations and journal publications
• Build and maintain strong relationships with local and international research network

Job Requirements:

• Possess a PhD degree in microbiology, fermentation or relevant disciplines
• Excellent knowledge and experience in microbiology and food fermentation
• At least 5 year of independent research experience and leading a research team
• Strong supervisory skills
• Strong track record for securing research funding
• Excellent publication track record
• Excellent communication and interpersonal skills, with the ability to effectively engage with diverse stakeholders at all levels
• Track record of strategic thinking capability with a outcomes-oriented mindset, able to translate vision into actionable plans and driving their execution

Responsibilities

The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated Scientist or Senior Scientist to join a team developing a ribozyme-based RNA platform for potential translational and/or clinical applications.

The work will involve both in vitro and in vivo techniques, including molecular biology (RNA design, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology (cell culture, cell transfection, flow cytometry, antisense oligonucleotides and RNAi, CRISPR), high-resolution imaging techniques, and experiments in mouse models (e.g. transgenesis, in situ hybridization and immunohistochemistry, imaging and functional analyses)

Requirements

• Minimum Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Genetics, Neuroscience or a related discipline.
• The successful candidate should have strong expertise in RNA biology, cell biology, biochemistry and molecular biology techniques, a strong publication record that includes a first author research paper, and strong scientific writing skills.
• They should be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary, and the successful candidate should be able to work effectively and harmoniously in a diverse team.
• As a Scientist, candidate will also be expected to mentor and train students and Research Officers.

We are seeking a passionate and skilled Flutter Developer to join our dynamic team. The ideal candidate will have a strong understanding of Flutter development, be proficient in Dart programming, and have experience building high-quality, scalable mobile applications.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications using Flutter.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Job Requirements:

• At least 5 years relevant experience in Flutter development. Candidates with no experience and possess relevant technical knowledge may apply.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Dart programming language.
• Proven experience in building mobile applications for Android and iOS using Flutter.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description:

• Support procurement process at DxD Hub, ensuring technical and policy compliance as well as value-for-money.
• Structuring requirements for procurement process: Translate purchase requests from technical team to online procurement systems.
• Perform and/or support activities throughout procurement process. Example activities include creating internal approval memos and justification, preparing external documents (e.g. Invitation to Quote, Tenders).
• Support proposal evaluation: work with users to perform structured assessment of vendor proposals and recommend proposal to award.
• Partner with executives in other functions including Procurement and Finance to ensure efficient operations.
• Collate and track data to support analysis, including maintaining databases and hard copy records.
• Ensure that database is updated in a timely and accurate manner.
• Provide general administrative and clerical support to DxD Hub Team ensuring safe and comfortable DxD Hub operations.
• General administrative and clerical support to DxD Hub Team.
• Manage and monitor inventory of office and pantry supplies and re-order as needed.
• Track non-scientific equipment and assets (e.g. video conferencing system, furniture) and work with vendors for maintenance.
• Monitor facilities vendors (e.g. cleaning, telecom) to ensure a comfortable office environment for staff including light clean-up as needed.
• Work closely with SpIA and HR for the issuance of staff card for new hires and ensure that the staff has access to all DxD office sites.

Job Requirements:

• Diploma holder with a certificate in professional secretarial skills/ finance.
• Minimum 2 years of relevant experience in similar capacity.
• Experience in purchasing of biomedical consumables and equipment would be an advantage.
• Proficient in MS Office Applications, including Word, Excel, PowerPoint, and Outlook.
• A team player with excellent interpersonal, communication and organisational skills.
• Able to communicate effectively, multi-task, and work in a dynamic environment.
• Well organised and good written communication skills.
• Awareness of workplace health and safety would be an advantage.
• Meticulous and able to work independently in a fast-paced environment.
• Individual who is self-motivated, and results driven.
• Proactive and takes ownership of projects.
• Adaptable and able to work under pressure.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Digital Health Accelerator (DHA) is led by A*STAR, Ministry of Health (MOH) Singapore, SingHealth, National Healthcare Group (NHG), and National University Health System (NUHS). DHA supports innovators in driving adoption and scaling of market ready or near-market ready digital health solutions. DHA is hosted by Singapore's Diagnostics Development Hub (DxD Hub).

The DHA integration engineer is responsible for planning and developing workflow and technical interfaces between healthcare IT systems. She/He will work with DHA Project Managers, Solution Architects, health systems and companies to accomplish this objective. She/He may also be called upon to advise other developers on integration standards.

Responsibilities:

• You’ll be involved in the development, design, build, testing, and go live phases of multiple integration projects.
• This includes scripting to conform / transform to another systems specifications.
• You will also work with internal teams to continuously improve processes and procedures around deployment of interoperability products that communicate in HIT standards-based formats such as HL7, IHE Profiles, Direct, or SMART on FHIR.
• The Integration Engineer oversees the development of new interfaces and maintain the sandbox environment up to date for application testing.

Requirements:

• Bachelor’s degree in information systems, Computer Science, Engineering, Computer Information Systems, Management Information Systems, or equivalent experience
• 3+ years’ experience in HCIT integration using established and contemporary interoperability standards (e.g. HL7, SMRT, FHIR)
• Experience with SQL and relational databases, and communication using secure protocols.
• Ability to work in a team environment alongside developers and deployment teams.
• Utilise engines like Mirth Connect or Rhapsody to have a standard way of integration using both HL7 and DICOM
• Knowledge in developing and configuring Context Launch requirements according to AES 256 standards.
• Assess and customise integrations (HL7 / FHIR / DICOM) based on the project to specific workflow.
• Experience with cloud deployments and/or pipelines, especially Pivotal Cloud Foundry
• Experience with popular healthcare integration engines with ability to recommend and/or select different integration approaches depending on the desired outcomes for the system.
• Strong communication skills and ability to work with project stakeholders from different backgrounds (e.g. technical, clinical)
• Experience integrating with Singapore public hospital technical stack and working with Synapxe are a plus.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Digital Health Accelerator (DHA) is led by A*STAR, Ministry of Health (MOH) Singapore, SingHealth, National Healthcare Group (NHG), and National University Health System (NUHS). DHA supports innovators in driving adoption and scaling of market ready or near-market ready digital health solutions. DHA is hosted by Singapore's Diagnostics Development Hub (DxD Hub). The DHA integration engineer is responsible for planning and developing workflow and technical interfaces between healthcare IT systems. She/He will work with DHA Project Managers, Solution Architects, health systems and companies to accomplish this objective. She/He may also be called upon to advise other developers on integration standards.

Responsibilities:

• You’ll be involved in the development, design, build, testing, and go live phases of multiple integration projects.
• This includes scripting to conform / transform to another systems specifications.
• You will also work with internal teams to continuously improve processes and procedures around deployment of interoperability products that communicate in HIT standards-based formats such as HL7, IHE Profiles, Direct, or SMART on FHIR.
• The Integration Engineer oversees the development of new interfaces and maintain the sandbox environment up to date for application testing.

Requirements:

• Bachelor’s degree in information systems, Computer Science, Engineering, Computer Information Systems, Management Information Systems, or equivalent experience
• 5+ years’ experience in HCIT integration using established and contemporary interoperability standards (e.g. HL7, SMRT, FHIR)
• Experience with SQL and relational databases, and communication using secure protocols.
• Ability to work in a team environment alongside developers and deployment teams.
• Utilise engines like Mirth Connect or Rhapsody to have a standard way of integration using both HL7 and DICOM
• Knowledge in developing and configuring Context Launch requirements according to AES 256 standards.
• Assess and customise integrations (HL7 / FHIR / DICOM) based on the project to specific workflow.
• Experience with cloud deployments and/or pipelines, especially Pivotal Cloud Foundry
• Experience with popular healthcare integration engines with ability to recommend and/or select different integration approaches depending on the desired outcomes for the system.
• Strong communication skills and ability to work with project stakeholders from different backgrounds (e.g. technical, clinical)
• Experience integrating with Singapore public hospital technical stack and working with Synapxe are a plus.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Requirements:

• At least a minimum of 5 years of relevant experience in IOS/Android App development.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Flutter, React, Dart and native programming language.
• Proven experience in building mobile applications for Android and iOS.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to identify and validate candidates that address the body’s adaptive responses to weight loss.

TaRgeted Analysis of Novel Secreted Factors for Obesity Reduction and Metabolic Health (TRANSFORM)

Description:

Multi-omic analysis of secreted factors from various datasets was carried out, including human, mouse and primate plasma and metabolic tissues to identify novel primate-specific secreted factors critically involved in the regulation of physiology balance. Integrative data analysis and in silico rank scoring revealed a list of promising secreted factor candidates. We will be using model organisms (e.g. mice, zebrafish) to conduct phenotypic screens and prioritize candidates for detailed validation, characterization, mode-of-action studies and therapeutic strategies.

Job responsibilities:

● Conduct in vitro wet lab experiments for identified candidates (e.g. cell culture, molecular biology and assays, protein chemistry, pharmacological efficacy etc)

● Conduct in vivo screening experiments for prioritized candidates (e.g. in preclinical models of obesity)

● Conduct end-point and mechanistic experiments (e.g. target tissue and blood collection, sample preparation etc)

● Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings

● Interact and collaborate with and assist other researchers and collaborators on related projects

● Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction

● Assist in the preparation of grant applications and grant process reports

● Present findings both orally and in written form via presentations and publication in peer-reviewed journal

● Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals

● Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

Responsibilities

The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated Scientist or Senior Scientist to join a team developing a ribozyme-based RNA platform for potential translational and/or clinical applications.

The work will involve both in vitro and in vivo techniques, including molecular biology (RNA design, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology (cell culture, cell transfection, flow cytometry, antisense oligonucleotides and RNAi, CRISPR), high-resolution imaging techniques, and experiments in mouse models (e.g. transgenesis, in situ hybridization and immunohistochemistry, imaging and functional analyses)

Requirements

• Minimum Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Genetics, Neuroscience or a related discipline.
• The successful candidate should have strong expertise in RNA biology, cell biology, biochemistry and molecular biology techniques, a strong publication record that includes a first author research paper, and strong scientific writing skills.
• They should be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary, and the successful candidate should be able to work effectively and harmoniously in a diverse team.
• As a Scientist, candidate will also be expected to mentor and train students and Research Officers.

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with at least 5 years experience in dermatology, immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal

Your application will be processed only if you apply via NUS Career Portal

We regret that only shortlisted candidates will be notified.

Job Description

Applications are invited for the following full-time position in the Saw Swee Hock School of Public Health:

A research associate position is available at the Saw Swee Hock School of Public Health to support a principal investigator in cardiovascular disease epidemiology research projects.

Key Responsibilities:

The research associate will independently analyse proteomic and clinical data, contributing significantly to the understanding of cardiovascular disease. The role involves writing manuscripts focused on heart failure and developing and writing research grant proposals to secure funding for ongoing and future projects. The successful candidate will work closely with diverse experts, including epidemiologists, data scientists, and clinicians, to drive research initiatives in cardiovascular disease, ensuring a collaborative approach to advancing scientific knowledge in this field.

Qualifications:

• Strongly proficient in statistical software (R preferred, Stata, or Python).
• Experience in analysing clinical datasets
• Proficiency in Microsoft Office Applications, particularly MS Word and Excel.
• Strong skills in scientific writing and experience.
• Excellent written and verbal communication skills.
• Ability to work effectively and independently in a team environment.
• Master's degree in Statistics, Public Health with a strong quantitative background, Computer Science, or Mathematics with relevant experience in data science.

Additional Information:

• Recruitment is open immediately and will continue until the position is filled.
• Applicants should send a brief statement of interest, CV, three named references, and other supporting documents during the application process.

If you are passionate about applying data science to advance heart failure research, we invite you to join our team and make a difference.

Recruitment is open immediately and will continue until the position is filled. Applicants should send a brief statement of interest, CV, three named references, and other supporting documents during the application.

We regret that only shortlisted candidates will be notified

Host Pathogen Interactions Lab in A*STAR Infectious Diseases Labs (A*STAR IDL) is actively seeking a Scientist to join our mission of becoming a leading center for infectious diseases research. A*STAR IDL is dedicated to advancing translational research in infectious diseases to improve both health and economic outcomes.

Job Description:

We are seeking a talented researcher to lead the research on a 3 year funded research project as well as develop novel ideas in the broad scope of host-pathogen interactions and infectious diseases. Preliminary data gathered will help develop the researcher’s career and path to independence through the various early-career support available internally in A*STAR as well as in the Singapore ecosystem.

The funded project will aim to characterize and compare host-alphavirus interactions at the immune response level in vivo in animal models through a novel viral-centric approach. Preliminary data of the lab has shown a differential adaptive immune response polarization between two alphaviruses and identified, via in vivo comparative multiOmic approaches, a set of candidate host factors potentially responsible for the phenotype. The project will entail a close characterization of these host factors and their role in the viral life cycle as well as the modulation of the immune response of small animal model to these viruses. In addition to multi-Omics approaches (including single-cell and spatial), protein-protein interactions, microscopy, functional genomics, viral reverse genetics and CRISPR Cas9 gene editing will be some of the tools used to investigate this viral hijacking and understand the host-viral interplay. Animals models available in the lab include mice and zebrafish. Downstream of characterization will aim to validate these targets in small preclinical models for subsequent drug discovery in the A*STAR ecosystem. Throughout the project, close collaborative work within A*STAR IDL as well as other institutes throughout Singapore and overseas will be used to leverage expertise for high impact studies.

Job Requirements

• PhD in Biomedical Sciences, Life Sciences, Immunology or related field
• Atleast 2 years of relevant experience in immunology or related field. No virology experience necessary.
• Highly motivated and able to work independently.
• Team player with good interpersonal skills.
• Good spoken and written communication skills.
• Familiar with bioinformatics
• Willing to learn to work in a BSL3 facility if necessary
• Must be comfortable to work with small animal models.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Host Pathogen Interactions Lab in A*STAR Infectious Diseases Labs (A*STAR IDL) is actively seeking a Scientist to join our mission of becoming a leading center for infectious diseases research. A*STAR IDL is dedicated to advancing translational research in infectious diseases to improve both health and economic outcomes.

Job Description:

We are seeking a talented researcher to lead the research on a 3 year funded research project as well as develop novel ideas in the broad scope of host-pathogen interactions and infectious diseases. Preliminary data gathered will help develop the researcher’s career and path to independence through the various early-career support available internally in A*STAR as well as in the Singapore ecosystem.

The funded project will aim to characterize and compare host-alphavirus interactions at the immune response level in vivo in animal models through a novel viral-centric approach. Preliminary data of the lab has shown a differential adaptive immune response polarization between two alphaviruses and identified, via in vivo comparative multiOmic approaches, a set of candidate host factors potentially responsible for the phenotype. The project will entail a close characterization of these host factors and their role in the viral life cycle as well as the modulation of the immune response of small animal model to these viruses. In addition to multi-Omics approaches (including single-cell and spatial), protein-protein interactions, microscopy, functional genomics, viral reverse genetics and CRISPR Cas9 gene editing will be some of the tools used to investigate this viral hijacking and understand the host-viral interplay. Animals models available in the lab include mice and zebrafish. Downstream of characterization will aim to validate these targets in small preclinical models for subsequent drug discovery in the A*STAR ecosystem. Throughout the project, close collaborative work within A*STAR IDL as well as other institutes throughout Singapore and overseas will be used to leverage expertise for high impact studies.

Job Requirements

• PhD in Biomedical Sciences, Life Sciences, Immunology or related field
• At least 4 years of relevant experience in immunology or related field. No virology experience necessary.
• Highly motivated and able to work independently.
• Team player with good interpersonal skills.
• Good spoken and written communication skills.
• Familiar with bioinformatics
• Willing to learn to work in a BSL3 facility if necessary
• Must be comfortable to work with small animal models.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.