Provide process engineering expertise for process design, process scale-up, trouble-shooting and process efficiency improvements. Interrogate laboratory working directions to determine optimum plant configuration to ensure that the process [chemistry + plant] meets the scale-up objectives in a safe manner. Support capital projects for R&D Jurong.
Key Responsibilities
Lead process engineering activities for NCE projects in the pilot plant
- Review of chemistry scale-up requests with Chemists, Operations and Engineering to determine optimum plant configuration.
- Define detailed plant and modification design. The time period for introducing new chemistry onto plant is usually less than 4 weeks, during which time any new equipment requirements must be identified, designed, fabricated, installed [by on-site staff or contractors], commissioned, tested and operating staff trained in use before chemical processing starts.
- Agree level of hazard assessment with Operations and complete Process Risk Assessment.
- Review batch record, carry out installation checks, write WI [Work Instruction] or SOP [Standard Operating Procedure] as required and train operators.
- Support campaign on plant, troubleshooting any engineering issues.
Technology Transfers
- Generate sufficient process engineering information for GSC to ensure that the process can be effectively introduced into the desired production plant.
- Support synthetic organic chemists, process safety scientists, and process chemists in the design of processes suitable for effective scale-up.
- Assess critical process characteristics and requirements as well as existing plant capabilities and limitations by gathering and interpreting suitable experimental data.
- Significantly contribute to the development of robust manufacturing processes for the synthesis of bulk drug substance by evaluating alternative processing strategies and recommending potential process improvements.
- As a member of the ChemDev project team, identify and effectively communicate the best suitable scale-up strategy for a process including recommendations for the application of new processing technologies.
- Play an important role in facilitating a seamless technology transfer of processes to GSC by the application of state-of -the-art tools and procedures.
Capital Projects
- Act as client representative for capital projects, to ensure all the customer needs are incorporated into the design and installation of new plant and equipment.
- Identify areas of weakness in the portfolio of processing technologies (plant and equipment) and submit proposals to address these.
- Define and seek approval for the detailed project scope of plant and equipment projects, and obtain approval for capital orders and PIP's.
- Review and make recommendations on design proposals put forward by contractors, project engineers, and equipment suppliers.
- Organise HAZOP studies, act as technical recorder, and issue HAZOP report for all installations where appropriate.
- Issue commissioning programmes, lead commissioning activities, and issue final reports.
- Carry out pre-delivery inspection visits for new equipment, prior to acceptance on site.
- Compile equipment WIs.
Knowledge, Skills & Experience
- Min A level certification
- Experience in pharmaceutical industry
- Experience in pharmaceutical process
- In depth working knowledge of the safety and compliance requirements for equipment and systems used in it.
- Strong written and verbal communication skills.
- Ability to multi-task and prioritize workload
To learn more about Singapore GSK and our people, please click on this link: https://www.linkedin.com/company/glaxosmithkline/life/gsksingapore
#Li-GSK
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
