A Postdoctoral Scientist (Bioinformatician) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools Bioinformatician position
A Bioinformatician position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools and strategies in deriving desired cell types for therapeutic applications.
Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.
Requirements:
- Ph.D./ M.Sc. from a well-recognized institution with a strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent
- Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics and Spatial-seq
- Experience with open-source bioinformatics tools
- Excellent analytical, technical, and problem-solving skills
- Knowledge with biostatistics highly desirable
- Self-starter who is comfortable working in a fast-moving interdisciplinary team
- Committed and able to work flexible hours
- Excellent communication, technical writing, and presentation skills
Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).
References:
1) Cipta NO, Chen Y, Loh YH#. H3.3 safeguards haematopoietic ERV-quilibrium Nature Cell Biology 2021(In press)
2) Gautam P, et al., Loh YH#. Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nature Communications 2021 Sep 24; 12, 5675 #As Corresponding author
3) Xing QR, et al., Loh YH#. Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility Sequencing. Science Advances. 2020 Sep 11. 6:37, eaba1190. doi: 10.1126/sciadv.aba1190
4) Xing QR, et al., Loh YH#. Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility. Genome Research 2020 Jul;30(7):1027-1039. doi: 10.1101/gr.257840.119.
5) Fang HT, et al., Loh YH#. Global H3.3 dynamic deposition defines its bimodal role in cell fate transition. Nature Communications 2018 Apr 18;9:1537
6) Yang BX, et al., Loh YH#. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell 2015163(1):230-45
7) Agarwal S, Loh YH, et al., Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464, 292-296.
8) Loh YH et al., Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 2006 38, 431–440.and strategies in deriving desired cell types for therapeutic applications.
Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.
Requirements:
- PhD with strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent.
- Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics, and Spatial-seq.
- Experience with open-source bioinformatics tools.
- Excellent analytical, technical, and problem-solving skills.
- Knowledge of biostatistics highly desirable.
- Self-starter who is comfortable working in a fast-moving interdisciplinary team.
- Strong publication record in peer-reviewed journals.
- Committed and able to work flexible hours.
- Excellent communication, technical writing, and presentation skills.
Interested candidates are asked to send a cover letter detailing their research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]).
Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).
