The Innovation & Enterprise Fellowship Programme (IFP) seeks to grow the pool of deep-tech talent in Singapore with the capabilities to support the commercialisation of deep-tech research and bring nascent technologies to market. Targeting researchers, scientists, and engineers (RSEs), the programme aims to develop industry relevant innovation and entrepreneurial skills through both formal and on-the-job training.
At EDDC, our goal is to discover and develop novel therapeutics by working collaboratively with public sector and industry partners. EDDC now has an opening and is seeking to recruit a highly motivated and skilled Research Fellow with strong background in RNA biology for the IFP in the Chemical Biology group at EDDC. This is an eighteen-month on-the-job training programme that involves participation in and supporting inter-disciplinary and collaborative drug discovery projects. The successful candidate will be responsible for designing and executing experiments to investigate the role of RNA in gene expression and regulation. This position will involve working with a variety of RNA species, including messenger RNA, non-coding RNA, and small RNAs, as well as RNA-binding proteins.
Responsibilities:
- Develop and apply RNA biology techniques to drive small molecule drug discovery programmes and characterise the mechanisms of small molecule candidates in disease models
- Design, optimise, analyse, and troubleshoot molecular biology and cell-based assays to screen, validate hits and confirm the activity of the small molecule
- Work effectively and closely with cross discipline teams across multiple fields, including computational biology and chemistry
- Hone scientific and technical expertise by keeping up to date on the relevant literature and attending workshops and conferences
Requirements:
- Ph.D. in RNA Biology, Biochemistry, Genetics, or related field with 0.5 years of academic and/or industry experience
- Extensive experience in RNA biochemistry techniques including RNA-seq, SHAPE-seq or other RNA chemical probing techniques to investigate RNA structure-function relationships
- Hands-on expertise in mammalian cell culture, cell-based assays, and cell line engineering via CRISPR for genetic perturbation
- Experience in data analysis using Python or R is a significant plus
- Ability to work independently to design and troubleshooting experiments
- Strong analytical and problem-solving skills
- Excellent communication and interpersonal skills
- Proven track-record of research productivity, including peer-reviewed publications in high-impact journals
This is a 1 year contract duration position.
The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.
