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Job Description
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on organoid research?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Fellow to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537). The role will provide expertise in the establishment, genetic manipulation and maintenance of human and murine organoid cultures as well as design/ perform and analyse work within the project parameters.
Duties And Responsibilities
Research:
o Develop hypotheses and conceptualise, design and execute experiments to address the hypothesis
o To establish, engineer (e.g. by CRISPR) and maintain 3D organoid cultures from a variety of tissue systems
o To carry out molecular and cell biology experiments (i.e. cloning, FACS, western blotting, RNA, sequencing, microscopy) and perform analysis and determinations
o To organise, preserve and present the results of the experiments in a logical manner
o To properly and systematically record all experiments that have been assigned and their results
o To assist in supervising, training and guiding attachment/undergraduate students where required
Qualifications
ESSENTIAL qualifications include:
- A PhD with 1-3 years’ relevant post-doctoral experience
- Strong track record of research achievement evidenced by high-quality publications in a relevant field
- High-level experience in hands-on use of a wide range of relevant research methods with a focus on organoid work
- Skills in working independently and creatively to solve experimental problems and
- Effective communication and presentation skills, with experience in communicating scientific work including scientific papers, presentations and reports.
Preference will be given to candidates with:
- Familiarity with the development of phenotypic assays for genetic or chemical screening, involving the use of flow cytometry, high-throughput high-content microscopy, and/or advanced fluorescence microscopy
- Previous experience with genetically engineered murine models, or
- Knowledge of IRB, HBRA & IACUC regulations
