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Job Description
The successful candidate will work with Professor Eric Chan on Project Theme 5: Safety, Risk and Nutritional Assessment of alternative protein ingredients under a project on Development of non-animal New Approach Methodologies (NAMs) to innovate Next Generation Risk Assessment (NGRA) based on physiologically based toxicokinetic-toxicodynamic (PBTK-TD) modelling and simulation.
The main responsibilities of the position include:
- Conduct research and development of non-animal in vitro and in silico New Approach Methodologies (NAMs) for Next Generation Risk Assessment (NGRA).
- Lead the design and execution of physiologically based toxicokinetic-toxicodynamic (PBTK-TD) modeling and simulation studies.
- Analyze, interpret, and validate experimental data to develop models predicting toxicokinetic and toxicodynamic behaviors of xenobiotics (food and drug).
- Collaborate with cross-functional teams (e.g., pharmacologists, toxicologists, biostatisticians, regulators) to integrate models with in vitro, in silico and in vivo data.
- Contribute to the preparation of research grant proposals, scientific manuscripts, technical reports, and presentations for both academic and industrial stakeholders.
- Present research outcomes at internal meetings, local, regional and international conferences, and in peer-reviewed journals.
- Stay updated on regulatory frameworks and advancements in NAMs and NGRA.
Qualifications
Qualifications / Discipline:
- PhD in Pharmacy, Physiology, Pharmacology, Toxicology, or related field with a focus on modeling and simulation.
- Strong knowledge of toxicokinetics and toxicodynamics, with expertise in PBTK-TD models.
- Background in systems biology, computational biology, or similar areas relevant to modeling complex biological systems.
- Experience with in vitro and in silico techniques, especially in the context of non-animal risk assessment.
Skills:
- Proficiency in modeling software (e.g., Simcyp, GastroPlus, MATLAB, or similar tools for PBTK-TD simulation).
- Strong analytical and quantitative skills for data interpretation and validation.
- Excellent verbal and written communication skills for technical reporting and collaborative research.
- Ability to work in a multidisciplinary team and manage multiple research activities.
- Problem-solving skills to address challenges in modeling and data integration.
Experience:
- Prior experience in developing and validating PBTK or other physiology-based models in academia or industry.
- Demonstrated experience in Next Generation Risk Assessment and/or non-animal in vitro and in silico methodologies is preferred.
- Proven track record of publications in relevant fields (modeling, toxicokinetics, risk assessment).
- Experience working on collaborative research projects involving multiple stakeholders (academic, industry, or regulatory).
