The Laboratory for RNA Delivery Therapeutics @ NTU
The School of Chemistry, Chemical Engineering and Biotechnology (CCEB) invites applications for the position of Research Fellow in Prof Mary Chan-Park team. Prof Mary Chan-Park and her team have recently won a highly competitive large grant on the design, synthesis and studies of the improved RNA delivery vehicles.
Prof Mary Chan-Park is currently the Centre Director of the Centre for RNA Delivery Therapeutics. She is also the current President Chair Professor of Chemistry, Chemical Engineering and Biotechnology (2024 onwards) and the 2019 Board of Trustees Chaired Professor of Chemical and Biomedical Engineering (2019-2024), both at the Nanyang Technological University Singapore (NTU Singapore). She also holds a joint appointment at the Lee Kong Chian School of Medicine at NTU. She is the Director of the Centre for Antimicrobial Bioengineering and the Director of the NTU Laboratory for RNA Delivery Therapeutics. She is a Fellow of the America Institute of Medical and Biological Engineering.
The Research Fellow will take on a significant role to design and synthesize new lipids or polymers that are stimuli-responsive and suitable for nanoparticle delivery formulations. New alternative delivery vehicles for the promising RNA nanomedicine are urgently needed to replace the current ones to achieve great delivery efficacy with less side effects. We have shown that some polymeric or lipid nanoparticles are excellent candidates as delivery agents.
Key Responsibilities:
- Design and synthesize novel stimuli-responsive lipids or polymers for RNA delivery formulations to achieve efficient transfection and endosomal escape.
- Develop cationic or ionizable lipids or polymers for RNA delivery applications.
- Collaborate with team members to formulate lipids/polymers with RNA for transfection experiments.
- Measure and evaluate transfection efficiency, endosomal escape efficiency, and other particle properties.
Job Requirements:
- PhD in Chemistry, Chemical Engineering, Materials Science, or related field
- At least 5 years of relevant experience in lipid/polymer synthesis and design for stimuli-responsive nanoparticle delivery, particularly RNA delivery formulations.
- Familiarity with advanced lipid/polymer design for RNA delivery and nanoparticle formulations (e.g., classical LNPs and top research groups).
- Strong written and oral communication skills.
- Proficiency in lipid/polymer synthesis is essential.
- Competence in technical communication and leadership, including supervising junior researchers (e.g., PhD students).
- Strong interpersonal skills, with the ability to work independently, meet deadlines, and manage time effectively.
- Entry-level PhD graduates are welcome to apply. Recent PhD graduates in chemistry, chemical engineering, materials science, and engineering or related fields with knowledge in organic or polymer synthesis are strongly encouraged to apply or inquire.
We regret that only shortlisted candidates will be notified.
