Total 3,445 research officer job vacancies in Education / Training category in Singapore

Roles & Responsibilities:

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying allergenomics and immunogenicity in the context of human health. The candidate will work on primary cells from cohorts and cell culture systems towards understanding allergenicity and immune responses. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Requirements:

• PhD Degree in Allergy, Novel foods, Food/Nutrition Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in allergenomics , immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

COMPANY DESCRIPTION

Singapore Management University is a place where high-level professionalism blends together with a healthy informality. The 'family-like' atmosphere among the SMU community fosters a culture where employees work, plan, organise and play together building a strong collegiality and morale within the university.

Our commitment to attract and retain talent is ongoing. We offer attractive benefits and welfare, competitive compensation packages, and generous professional development opportunities all to meet the work-life needs of our staff. No wonder, then, that SMU continues to be given numerous awards and recognition for its human resource excellence.

RESPONSIBILITIES

Interdisciplinary research is necessary to address many of the key issues of our times. Unfortunately, there are significant barriers to interdisciplinary collaboration. These include, among others, differences in publication conventions and norms among disciplines, tenure and academic promotion processes favouring single-discipline research, and perceptions that interdisciplinary research is less rigorous than single-discipline research. While these challenges are likely to resonate with interdisciplinary scholars, there is a need to move beyond an evidence-base that is mostly anecdotal towards a systematic understanding of these practical challenges.

In this project, the Research Fellow will work together with Associate Professor Terry van Gevelt to identify and quantify practical challenges to interdisciplinary research using the field of energy studies as a vehicle. The successful candidate will possess a strong quantitative skillset and a demonstrated ability to problem solve.

Specifically, the Research Fellow will:

• Use web-scraping and textual analysis to generate a novel dataset
• Analyse the dataset using quasi-experimental methods
• Assist in the design and calibration of a choice experiment; and
• Make a significant contribution to the drafting of two research articles for submission to high-impact journals.

Please contact Associate Professor Terry van Gevelt ([email protected]) for any questions surrounding the position. The successful applicant will be expected to be based in Singapore for the duration of the 9-month contract.

• PhD in Quantitative Social Sciences, Computational Social Sciences, Economics, or a related discipline.
• Demonstrated ability to undertake textual analysis and (Quasi-)experimental methods.

Applicants will need to provide a CV and a cover letter.

#LI-XL1

The Singapore University of Tecnology is looking for a Research Assistant in the area of networked systems and cybersecurity. The successful applicant will work closely with a team of researchers and engineers to design and develop novel solutions for various types of networked systems (including industrial control systems and 5G systems).

Qualification & Experience:

• Bachelor's / Master's in Computer Science, Computer Engineering, or related discipline.
• Expertise in computer networks and cybersecurity.
• Research experience, technical skillset, and strong publication records in the area of networked systems, cybersecurity, or related areas.
• Strong software skills
• Ability to work well in a collaborating team setting
• Good written/oral communication skills in English

Job Scope

• To conduct laboratory tests
• To handle samples and testing samples
• To assist in laboratory duties such as equipment maintenance, maintaining inventory, purchase of consumables and preparation of laboratory reagents/supplies, including laboratory cleaning and waste-disposal.

Requirement

• Prior experience with lab work especially molecular biology
• Diploma in Medical Technology / Life science related
• Currently studying a part-time degree

Interested applicants, please email your updated CV to [email protected] or WA 86517051 for more information.

Recruiter's Ref Code: #HXT

Lau Xin Tong, Evelyn (Outsourcing Team)

Recruit Express Pte Ltd (Healthcare & Lifescience)

Company Registration Number: Recruit Express Pte Ltd (99C4599)

NTI-NTU Corporate Laboratory is a collaboration between Nanofilm Technologies International Limited (“Nanofilm”, “NTI”), Nanyang Technological University (“NTU”) and supported by Singapore under RIE2025. The Laboratory’s objective is to propel Innovation and Technologies commercialisation through NTU’s innovation and NTI’s deep technology. NTI-NTU Corporate Laboratory aligns with Singapore’s RIE2025 handbook – which emphasises the nation’s commitment to research and innovation, aiming to drive economic growth and address national challenges.

The Nanyang Technological University NTI-NTU Corporate Laboratory is seeking to hire a Research Scientist. The selected candidate will innovate hybridized composite materials and thin film coatings.

Key Responsibilities:

• Optimize vacuum coating processes, and leading R&D efforts in material science for application development.
• Drives the development and implementation of coating techniques.
• Conducts various design simulations to refine processes.
• Oversee the transition from experimental designs to scalable solutions.
• Additionally, the role requires preparation and delivery of comprehensive reports to satisfy the stipulations of funding entities and corporate mandates.

Job Requirements:

• Ph.D. in a relevant engineering or science discipline is required.
• At least 5 years of combined specialized post-doctoral experience in industry or a recognized research institute.
• Expertise in hybrid materials, composite materials, polymer engineering, failure analysis and a strong track record of research publications and patent filings are essential.
• Applicants must demonstrate effective collaboration skills in multidisciplinary settings.

We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

Job Description

The Tropical Marine Science Institute (TMSI) invites applicants for the above posts.

Duties and Responsibilities

• Regular field trips onboard a research vessel (may extend outside conventional office hours)
• Field trip planning and preparation
• Water profiling on research vessel using multiparameter optical sensors
• Water quality analysis in the lab using spectrophotometer
• Cell count in the lab under a microscope
• Cell culture and culture maintenance
• Post processing of data collected
• General maintenance of field trip equipment (preventive maintenance, timely calibration)
• General administrative duties (procurement etc.)

Salary will commensurate with qualifications and experience. The appointment will be for a period of 6 months and extendable depending upon the candidate’s performance.

Only shortlisted candidates will be notified.

Qualifications and Requirements

• Degree in Marine Science, Science or equivalent
• Good written and verbal communication skills in English

Requirements:

• Dip in Nursing
• Keen interest to do research nursing
• 3 - 4 days days a week (part time commitment) but start at as early as 7am
• Able to draw blood

Responsibilities:

• Responsible to handle patients in basic treatments
• Educate patients on the disease progress
• Identify at-risk patients
• Perform some outcome management and tracking of data.
• Perform blood taking for subject of studies
• Only Nurses with SNB license NEED APPLY

For interested candidate, please email your resumes to [email protected]

Denyse Nicole Tan Shuqin (#HDT)

Recruit Express Pte Ltd

CEI No: R1333503

Company EA license : 99C4599

Join our team if you're a self-confident and highly motivated individual. Being a quick learner with robust communication skills makes you an excellent fit. Experience the flexibility of working from home with adjustable hours.

Your core responsibilities involves

• Scheduling sales meetings with potential clients
• Updating current clients on company developments
• Handling administrative tasks tied to sales services

It's crucial to note that this position is entirely remote, demanding self-sufficiency and discipline. The salary range is $3,000 - $6,000 monthly. Candidates should possess a minimum of "A" Level, diploma, or degree qualifications.

Our clients, major stake holder in the healthcare industry, are looking for Agency Part Time Nurses to join their dynamic team!

Responsibilities:

• Responsible to handle patients in basic treatments

• Educate patients on the disease progress

• Identify at-risk patients

• Perform some outcome management and tracking of data.

• Perform blood taking for subject of studies

• 3 - 4 days days a week (part time commitment)

Only Nurses with SNB license NEED APPLY

Interested candidates please send in your resume to:

[email protected]

Anna

Outsourcing Team

Recruit Express Pte Ltd, EA License No.: 99C4599

NTI-NTU Corporate Laboratory is a collaboration between Nanofilm Technologies International Limited (“Nanofilm”, “NTI”), Nanyang Technological University (“NTU”) and supported by Singapore under RIE2025. The Laboratory’s objective is to propel Innovation and Technologies commercialisation through NTU’s innovation and NTI’s deep technology. NTI-NTU Corporate Laboratory aligns with Singapore’s RIE2025 handbook – which emphasises the nation’s commitment to research and innovation, aiming to drive economic growth and address national challenges.

The Nanyang Technological University NTI-NTU Corporate Laboratory is seeking to hire a Senior Research Fellow. The selected candidate will innovate in semiconductor packaging, focusing on metallization and wafer packaging.

Key Responsibilities:

• Optimize plasma-enhanced metallization, vacuum coating processes, and leading R&D efforts in material science for device performance enhancement.

• Drive the development and implementation of advanced metallization techniques.

• Propose relevant vacuum coating solutions, conducting plasma simulations to refine processes.

• Oversee the transition from experimental designs to scalable solutions.

• Additionally, the role requires preparation and delivery of comprehensive reports to satisfy the stipulations of funding entities and corporate mandates.

Job Requirements:

• Ph.D. in a relevant engineering or science discipline is required.

• At least ten years of specialized post-doctoral experience.

• Expertise in plasma simulations (ANSYS, COMSOL) and a strong track record of research publications and successful grant applications are essential.

• Applicants must demonstrate effective collaboration skills in multidisciplinary settings.

We regret that only shortlisted candidates will be notified.

The School of Electrical and Electronic Engineering (NTU EEE) invites applications for the position of Research Associate. 

The eVTOL Research and Innovation Centre at Nanyang Technological University, Singapore, is looking for a strong candidate in the area of Thermal Management Systems.

Key Responsibilities:

• Lead the design and integration of thermal management systems for eVTOL aircraft, considering the unique challenges of electric propulsion and aerodynamics.

• Develop and implement strategies for efficient heat dissipation from critical components, including electric motors, inverters, and battery systems.

• Conduct thermal analysis and simulation to model and predict heat generation and dissipation within the aircraft systems under various flight conditions.

• Manage suppliers to select appropriate materials for thermal insulation and heat shielding, considering weight, durability, and thermal conductivity.

• Implement thermal barrier solutions to protect batteries from extreme temperatures.

• Develop and conduct lab tests, ground tests and flight tests to validate thermal management system performance under different operational scenarios.

• Generate detailed technical documentation, including specifications, thermal analysis reports, etc.

Job Requirements:

• Master’s degree in Electrical Engineering, Aerospace Engineering, or related field.

• Proven experience in thermal management system design for electric vehicles, aircraft, or similar applications.

• Proficiency in thermal analysis tools and simulation software.

• Knowledge of heat dissipation techniques, fluid dynamics, and thermodynamics.

• Strong problem-solving and analytical skills.

• Fluent English skill is a must.

We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The postdoctoral fellow will work closely with Asst. Prof. Patrick Rebentrost in the intersection of quantum algorithms and optimization, machine learning and/or finance. Sample topics include quantum algorithms for problems in supervised and unsupervised machine learning, algorithmic learning theory, and online learning, and quantum algorithms for financial problems such as portfolio optimization, pricing of financial derivatives, and hedging. The job will include the development of quantum algorithms in these areas, with provable quantum advantages and provable guarantees, when possible, in fault-tolerant models of quantum computation. The job will also include the development of algorithms that are easier to execute on available hardware such as variational and post-variational methods and quantum approximate optimization. Furthermore, the aim is to provide hardware implementations on available devices, comparisons between available hardware providers, and classical simulations of the quantum algorithms. For this purpose, the successful applicant will be granted significant independence concerning their research and receive generous travel funding. They will be expected to contribute to the group, for example by co-supervising student projects and assisting with outreach activities.

Qualifications

• Track-record working on quantum algorithms and/or quantum information. Candidates with expertise in other aspects of quantum computing such as quantum machine learning, near-term quantum algorithms, quantum approximate optimization are encouraged to apply.

• PhD in electrical engineering, computer science, physics or applied mathematics.

• Well-rounded research profile and ability to communicate research.

A Postdoctoral Scientist (Bioinformatician) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools Bioinformatician position

A Bioinformatician position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• Ph.D./ M.Sc. from a well-recognized institution with a strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics and Spatial-seq
• Experience with open-source bioinformatics tools
• Excellent analytical, technical, and problem-solving skills
• Knowledge with biostatistics highly desirable
• Self-starter who is comfortable working in a fast-moving interdisciplinary team
• Committed and able to work flexible hours
• Excellent communication, technical writing, and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:

1) Cipta NO, Chen Y, Loh YH#. H3.3 safeguards haematopoietic ERV-quilibrium Nature Cell Biology 2021(In press)

2) Gautam P, et al., Loh YH#. Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nature Communications 2021 Sep 24; 12, 5675 #As Corresponding author

3) Xing QR, et al., Loh YH#. Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility Sequencing. Science Advances. 2020 Sep 11. 6:37, eaba1190. doi: 10.1126/sciadv.aba1190

4) Xing QR, et al., Loh YH#. Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility. Genome Research 2020 Jul;30(7):1027-1039. doi: 10.1101/gr.257840.119.

5) Fang HT, et al., Loh YH#. Global H3.3 dynamic deposition defines its bimodal role in cell fate transition. Nature Communications 2018 Apr 18;9:1537

6) Yang BX, et al., Loh YH#. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell 2015163(1):230-45

7) Agarwal S, Loh YH, et al., Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464, 292-296.

8) Loh YH et al., Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 2006 38, 431–440.and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• PhD with strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent.
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics, and Spatial-seq.
• Experience with open-source bioinformatics tools.
• Excellent analytical, technical, and problem-solving skills.
• Knowledge of biostatistics highly desirable.
• Self-starter who is comfortable working in a fast-moving interdisciplinary team.
• Strong publication record in peer-reviewed journals.
• Committed and able to work flexible hours.
• Excellent communication, technical writing, and presentation skills.

Interested candidates are asked to send a cover letter detailing their research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]).

Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

Responsibilities

• Key account planning, development and management
• Act as main link resource to client.
• Develop and maintain close relationship and communication with decision makers of client / CRM
• Advise senior management of client status, problems and opportunities
• Quality control of all deliverables to client
• Develop, implement, coordinate, and manage research services projects
• Develop proposal and prepare budget/cost
• Questionnaire, interview/discussion guide design
• Analyze and evaluate results
• Develop conclusion and solid recommendation
• Present and report on work from proposal to analysis stage
• Control costs/budgeting
• Ensure company processes and compliance are followed
• Responsible for morale, productivity, and efficiency of team
• Any other tasks assigned by Commercial Director

The Centre for Urban Solutions is to provide leadership in developing innovative solutions and sustainable technologies for space creation and urban infrastructure development.

The School of Civil and Environmental Engineering (CEE) at Nanyang Technological University is a leading school for Sustainable Built Environment. It has over 50 faculty members and more than 1,500 students and is rapidly expanding its range of education and research activities.

Key Responsibilities:

• To be involved in a research project related to geotechnical engineering, particularly bored tunneling and data processing;
• The position involves in conducting research, supervising undergraduate students, and writing scientific articles.

Job Requirements:

• A PhD Degree in geotechnical engineering or equivalent from a recognized university;
• Able to work independently and collaborate with team members;
• Good verbal and written communication in English;
• Working or research experience in bored tunneling and data processing of at least 1 years is desirable.

We regret that only shortlisted candidates will be notified.

Job Scope

• To conduct laboratory tests
• To handle samples and testing samples
• To assist in laboratory duties such as equipment maintenance, maintaining inventory, purchase of consumables and preparation of laboratory reagents/supplies, including laboratory cleaning and waste-disposal.

Requirement

• Prior experience with lab work especially molecular biology
• Diploma in Medical Technology / Life science related

Interested candidates please send in your resume to:

[email protected]

EA Personnel: Valerie Yong Kian Fung

CEI No.: R1103704

Recruit Express Pte Ltd, EA License No.: 99C4599

Job Responsibilities:

• Work with technical and non-technical stakeholders to design and execute research testing how humans evaluate large language model (LLM) features.
• Conduct research with humans to validate and create automated benchmarks for LLM evaluations.

Requirements:

• PhD or advanced Degree in Computer Science, Machine Learning, Cognitive Science, Psychology, Economics, or similar discipline.
• Minimum 2 years of relevant experience in large language model research.
• Fluent in at least one statistical programming language such as Python or R.
• Strong understanding of machine learning principles, especially in the context of LLMs.
• Knowledgeable about LLM evaluation techniques, such as human evaluation and automated benchmarks.
• Able to own and pursue a research agenda, including choosing impactful research problems and autonomously carrying out projects.
• Demonstrated background in collecting data from human participants (e.g. surveys, experiments) with knowledge in data quality, data validity, etc.
• Strong communications skills with the ability to work effectively across internal and external organizations and virtual teams.

What you will be doing:

• Data Analysis Techniques: On statistical analysis, data visualization, and epidemiological research methods relevant to eye health studies.
• Epidemiological Principles: Understanding the fundamental principles of epidemiology, including study design, data collection, and data management.
• Research Ethics and Compliance: Understand ethical research practices and compliance with regulatory standards in Singapore.
• Communication Skills: Collaboration within the research team and presentation of findings.
• Project Management: Handle research projects and meet deadlines for paper submissions and grant applications.
• Practical Experience: Engaging in real-world data analysis projects and research

What you will need to have:

• Minimum MBBS or science-related degree with exposure in epidemiological studies
• Knowledge in various data analysis techniques
• Interest in epidemiological studies and data visualization

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

• The Research Assistant will work closely with the Principal Investigator on several research projects on using machine learning in chemical and control engineering problems
• The Research Assistant will help to develop machine learning models for both theory and applications in advanced control systems

Job Requirements

• A Bachelor degree in a relevant area, e.g., Chemical Engineering, Control Engineering, Computer Science, Chemistry, etc.
• Experienced in machine learning, optimization and programming languages (e.g., python, Matlab, C++, etc)
• Any experience with 1) advanced control, 2) machine learning theory and applications, and 3) chemical engineering and chemistry is a plus

Our clients, major stake holder in the healthcare industry, are looking for Agency Part Time Nurses to join their dynamic team!

Responsibilities:

• Responsible to handle patients in basic treatments
• Educate patients on the disease progress, can draw blood
• Encourage self-management
• Identify at-risk patients
• Perform some outcome management and tracking of data.
• 3 - 4 days days a week (part time commitment)

Only Nurses with SNB license NEED APPLY

Interested candidates please send a copy of your resume in MS Word to :

[email protected]

EA Personnel: Valerie Yong Kian Fung
CEI No.: R1103704
Recruit Express Pte Ltd, EA License No.: 99C4599

Job Summary:

Support with the data management and data analytics deliverables for Project RESET population health study (data collection, data monitoring, multi-modal data integration, data curation, data analytics and AI).

Job Responsibilities

• Implementation of effective data management processes across the clinical, multi-Omics and wearables data in Project RESET’s hybrid AWS cloud environment.
• Develop data management strategies for digital health technologies, ensuring the collection, integration and analysis of high-quality and reliable data.
• Develop and implement proactive quality control audits/quality management plans across longitudinal visits to ensure data accuracy, completeness and proper usage of data management systems.
• Develop and implement data models to identify patterns, correlations and predictive insights to assess patient risk stratification and disease progression.

Job Requirements

• A Bachelor/Master Degree in Public Health, Data Science, Statistics, Mathematics, Computer Science or related field.
• Good programming skills (Python, R, PyTorch, High Performance Computing solutions).
• Experience with advanced computational methods such as deep learning and graph neural networks for population health analytics.
• Knowledge/experience on Good Clinical Practice (GCP), Good Clinical Data Management Practices (GCDMP) guidelines and research data management.
• Good team player and communication skills for collaborative research.
• 0 - 3 years’ experience.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: Master’s degree in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: At least 2 years’ relevant work experience

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Research Assistant will work closely with the Principal Investigator (PI) to design and build desirable microstructure to enhance mechanical properties of steels by additive manufacturing.

The job scope of this position is:

• Conducting literature reviews and understanding state of the art
• Planning and implementing experiments
• Developing simulation models to guide microstructural engineering
• Analysing the experimental and simulation data
• Writing progress reports and research papers

Qualifications

• Bachelors/Masters Degree in Materials Science or Mechanical Engineering
• Knowledge of metallurgy and microstructural engineering is highly required
• Expertise in microstructural characterisation techniques (e.g. TEM, EBSD and FIB) and mechanical testing
• Expertise in numerical simulations (e.g. phase field, FEM)
• Experience with metal additive manufacturing (e.g. powder bed fusion, directed energy deposition) will be advantageous
• Good publication record will be advantageous
• Self-motivated, good team player

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: PhD or equivalent in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: Fresh PhD graduates or PhD holders with < 5 years of experience in any/some of above fields

We are looking for a highly motivated research officer who is interested in developing next-generation DNA and RNA therapeutics for treating genetic diseases. The individual will be involved in a multi-disciplinary project to develop new technologies and tools for precision editing of nucleic acids. There will be opportunities to further develop techniques in protein engineering, directed evolution, and synthetic biology.

Responsibilities:

• Design and clone constructs for experiments
• Perform activity characterization in vitro and in mammalian cells
• Perform qPCR/RT-qPCR of mammalian cells
• Perform high-throughput sequencing library preparation
• Analyze data and communicate results of experiments to colleagues
• Maintenance of laboratory equipment and general laboratory supplies

Job Requirement

• Bachelor’s Degree in Biochemistry, Biotechnology, Bioengineering, Biological Sciences, Chemistry, Chemical Engineering, or other related fields
• Experience with mammalian cell culture and molecular biology techniques (eg. molecular cloning, PCR, gel electrophoresis, miniprep)
• Experience with flow cytometry, protein expression, bacteriophage, high-throughput sequencing, or bioinformatics will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work
• Ability to work independently and as part of a team
• Excellent communication (verbal and written) and presentation skills
• Curiosity to learn new knowledge and skills