Total 12 job vacancies by A*star Research Entities

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. The ideal candidate need not specialise in all three aspects, but should be technically strong in at least one of these areas.

JOB REQUIREMENT

• Ph.D. in Immunology or Cell Biology or Biochemistry or Mass Spectrometry.
• Expertise in T-cell engineering highly preferred.
• Interested in data and computation.
• Solid publication record and strong scientific writing skills.
• Strong motivation and energy to lead project.
• Good organisational, verbal and interpersonal skills.
• Need to be a team player.
• Keen to learn

Understanding the pharmaco/nutrico/toxicokinetic behaviour of drugs, chemicals and food ingredients is a fundamental step in assessing the efficacy and safety of these materials. It can be challenging to study such substances directly in human subjects, while animal models lack direct translatability to humans due to inherent differences in species biology. One promising strategy is the use of physiologically-based pharmacokinetic (PBPK) modelling to predict the local tissue and systemic exposure of these substances. We have developed in-house in vitro and in silico tools to model chemical absorption, distribution, metabolism and excretion (ADME) in humans using data generated from in vitro assays. We apply these tools to predict pharmacokinetic profiles in different settings, ranging from oral or transdermal administration to studying special populations such as pregnant women, for a variety of substances including pharmaceuticals, food ingredients, environmental contaminants, essential micronutrients and microbial metabolites. These capabilities are further enhanced with state-of-the-art, enabling technologies such as the SHIME® intestinal digestion simulator and spatial mass spectrometry imaging.

The following tasks are expected of the candidate:

• Literature search to extract relevant ADME data for chemicals of interest
• Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays
• Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments
• Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals
• Develop new and/or improve features of in-house models, including pharmacodynamic modelling
• Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts
• Supervise and train students and interns

Qualifications

• PhD in Pharmaceutical Science, Life Sciences or equivalent.
• Strong understanding of ADME and pharmacokinetic concepts is essential.
• Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
• Prior experience with PBPK tools such as Simcyp®, GastroplusTM, PK Sim, Matlab/Simbiology or other models is desirable.
• Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Understanding the pharmaco/nutrico/toxicokinetic behaviour of drugs, chemicals and food ingredients is a fundamental step in assessing the efficacy and safety of these materials. It can be challenging to study such substances directly in human subjects, while animal models lack direct translatability to humans due to inherent differences in species biology. One promising strategy is the use of physiologically-based pharmacokinetic (PBPK) modelling to predict the local tissue and systemic exposure of these substances. We have developed in-house in vitro and in silico tools to model chemical absorption, distribution, metabolism and excretion (ADME) in humans using data generated from in vitro assays. We apply these tools to predict pharmacokinetic profiles in different settings, ranging from oral or transdermal administration to studying special populations such as pregnant women, for a variety of substances including pharmaceuticals, food ingredients, environmental contaminants, essential micronutrients and microbial metabolites. These capabilities are further enhanced with state-of-the-art, enabling technologies such as the SHIME® intestinal digestion simulator and spatial mass spectrometry imaging.

The following tasks are expected of the candidate:

• Literature search to extract relevant ADME data for chemicals of interest
• Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays
• Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments
• Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals
• Develop new and/or improve features of in-house models, including pharmacodynamic modelling
• Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts
• Supervise and train students and interns

Qualifications

• PhD in Pharmaceutical Science, Life Sciences or equivalent.
• Strong understanding of ADME and pharmacokinetic concepts is essential.
• Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
• Prior experience with PBPK tools such as Simcyp®, GastroplusTM, PK Sim, Matlab/Simbiology or other models is desirable.
• Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Understanding the pharmaco/ nutrico/ toxicokinetic behaviour of drugs, chemicals and food ingredients is a fundamental step in assessing the efficacy and safety of these materials. It can be challenging to study such substances directly in human subjects, while animal models lack direct translatability to humans due to inherent differences in species biology. One promising strategy is the use of physiologically-based pharmacokinetic (PBPK) modelling to predict the local tissue and systemic exposure of these substances. We have developed in-house in vitro and in silico tools to model chemical absorption, distribution, metabolism and excretion (ADME) in humans using data generated from in vitro assays. We apply these tools to predict pharmacokinetic profiles in different settings, ranging from oral or transdermal administration to studying special populations such as pregnant women, for a variety of substances including pharmaceuticals, food ingredients, environmental contaminants, essential micronutrients and microbial metabolites. These capabilities are further enhanced with state-of-the-art, enabling technologies such as the SHIME® intestinal digestion simulator and spatial mass spectrometry imaging.

The candidate in this position will be expected to be involved in the following activities:

• Literature search to extract relevant ADME data for chemicals of interest.
• Perform in vitro absorption, transporter, metabolism, fraction unbound and other related ADME assays.
• Quantify membrane protein, metabolic enzyme and xenobiotic concentrations within biological samples using liquid chromatography-tandem mass spectrometry (LC/MS/MS) instruments.
• Integrate appropriate in vitro and in silico data into PBPK models to predict the ADME of chemicals.
• Develop new and/or improve features of in-house models, including pharmacodynamic modelling.
• Write scientific grant proposals, maintain laboratory notebooks, prepare scientific reports, presentations and manuscripts.
• Supervise and train students and interns.

Qualifications

• PhD in Pharmaceutical Science, Life Sciences or equivalent.
• Strong understanding of ADME and pharmacokinetic concepts is essential.
• Prior experience in in vitro ADME assays and analytical mass spectrometry workflows is desirable.
• Prior experience with PBPK tools such as Simcyp®, GastroplusTM, PK Sim, Matlab/ Simbiology or other models is desirable.
• Able to work in a multi-disciplinary team, possess strong organizational and project management skills, demonstrate initiative and able to work independently.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. The ideal candidate need not specialise in all three aspects, but should be technically strong in at least one of these areas.

JOB REQUIREMENT

• Ph.D. in Immunology or Cell Biology or Biochemistry or Mass Spectrometry.
• Expertise in T-cell engineering highly preferred.
• Interested in data and computation.
• Solid publication record and strong scientific writing skills.
• Strong motivation and energy to lead project.
• Good organisational, verbal and interpersonal skills.
• Need to be a team player.
• Keen to learn

DxD Hub is a one-of-a-kind organisation dedicated to leading MedTech innovation through partnerships with a strong passion to create positive health outcomes. We bring together promising technologies and collaborate with our partners to ensure that their products are validated, registered, and successfully deployed.

We are seeking a dedicated Electrical and Electronics Engineer to join our team. As a vital member of our team, you will be involved in the design, development, and testing of electrical and electronic systems for medical devices, ensuring compliance with regulatory standards and industry best practices.

The ideal candidate will have a solid understanding of electrical and electronic engineering principles, proficiency in electrical design tools, and knowledge of medical device regulations (such as ISO 13485). Join our innovative team and make a positive impact on healthcare by creating cutting-edge medical devices that enhance patient care and well-being.

Roles and Responsibilities

• Support design of electrical and electronic systems, and components considering factors such as performance, safety, and regulatory compliance.
• Selecting and sourcing engineering components and liaising with purchasers, contractors, or suppliers.
• Conducting testing, verification, and validation activities for electrical and electronic systems to ensure compliance with regulatory standards and performance requirements.
• Participating in the development and assembly of prototypes, conducting testing and evaluation to validate design concepts and identify areas for improvement.
• Creating and maintaining technical documentation, including design specifications, test protocols, and reports, ensuring compliance with regulatory requirements such as ISO 13485.
• Collaborating with cross-functional teams, including project managers, engineers, scientists, quality, and regulatory personnel to achieve project objectives.

Key Requirements

• Bachelor’s Degree in Electronics Engineering, Electrical Engineering, Bioengineering, Biomedical Engineering, or related field.
• Proficiency in designing electrical systems, including schematic design, component selection, and ensuring compliance with safety and performance standards.
• Hands-on experience with micro-controllers/processors and peripheral circuits.
• Hands-on experience with PCB design, wiring, and circuit simulation.
• Experience with biomedical device development is a plus.
• Good understanding of testing and validation processes for electrical and electronic systems, including test plan development, test execution, and documentation.
• Knowledge of relevant regulatory standards and requirements, such as ISO 13485 and FDA regulations for medical devices.
• Ability to troubleshoot and resolve electrical and electronic issues that arise during the product development lifecycle.
• Strong analytical and problem-solving abilities to identify and resolve technical challenges, analyse data, and make informed engineering decisions.
• Excellent teamwork and communication skills to effectively collaborate with cross-functional teams, stakeholders, and external partners.evice regulations (such as ISO 13485).
• Join our innovative team and make a positive impact on healthcare by creating cutting-edge medical devices that enhance patient care and well-being.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Innovation & Enterprise Fellowship Programme (IFP) seeks to grow the pool of deep-tech talent in Singapore with the capabilities to support the commercialisation of deep-tech research and bring nascent technologies to market. Targeting researchers, scientists, and engineers (RSEs), the programme aims to develop industry relevant innovation and entrepreneurial skills through both formal and on-the-job training.

At EDDC, our goal is to discover and develop novel therapeutics by working collaboratively with public sector and industry partners. EDDC now has an opening and is seeking to recruit a highly motivated Research Officer for the IFP in the Oncology Discovery team at EDDC. The successful candidate will undergo an eighteen-month on-the-job training programme that involves participation in and supporting inter-disciplinary and collaborative drug discovery projects. This is an exciting opportunity to be a part of the team working on the discovery of novel therapeutics and engaging in preclinical drug development from target exploration to drug candidate selection.

Principle Roles & Responsibilities:

• Develop and perform biochemical, biophysical and cellular assays for functional characterization of small molecules and biologics.
• Analyze and present experimental data in a clear and concise manner, demonstrating a good understanding of its utilization and implications in the context of drug discovery.
• Perform molecular cloning, stable cell-line generation and CRISPR/Cas9 genome editing.
• Support laboratory housekeeping, safety check, SOP writing and other administrative and compliance-related processes.

Requirements:

• Degree or postgraduate degree in biology, biochemistry, biomedical sciences or related disciplines.
• At least 5 years of relevant experience
• Proficient in designing and conducting experiments within the areas of cancer biology.
• Experience in molecular biology and genome editing using CRISPR/Cas9.
• Experience in establishing high-throughput screening assays with the aim of identifying hits is a plus.
• Attention to detail, strong analytical and problem-solving skills.
• Ability to multitask and prioritize tasks, deliver results within timelines.
• Good written and oral communication skills, with meticulous record-keeping.
• Possess strong interpersonal and collaborative spirit.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. Initial contract of 2 years, extendable for another 2 years subject to positive performance.

JOB REQUIREMENT

• Ph.D. in Immunology or Cell Biology or Biochemistry or Mass Spectrometry
• Expertise in T-cell engineer highly preferred
• Interested in data and computation
• Solid publication record and strong scientific writing skills
• Strong motivation and energy to lead project
• Good organisational, verbal and interpersonal skills
• Need to be a team player

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Fellow to investigate the rules in cancer antigen discovery, towards therapeutic and preventive therapy. Project involves mass spectrometry, immunology and computation. Initial contract of 2 years, extendable for another 2 years subject to positive performance.

JOB REQUIREMENT

• Ph.D. in Immunology or Cell Biology or Biochemistry or Mass Spectrometry
• Expertise in T-cell engineer highly preferred
• Interested in data and computation
• Solid publication record and strong scientific writing skills
• Strong motivation and energy to lead project
• Good organisational, verbal and interpersonal skills
• Need to be a team player

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Officer to support ongoing research into cancer antigen processing and presentation. Project involves supporting the team on biochemistry and immunology experiments, as well as simple bioinformatics.

JOB REQUIREMENT

• Bachelor’s degree or Diploma holder with at least 5 years relevant experience in biomedical science or immunology.
• Laboratory skills in basic biochemistry and cell biology.
• Curious, keen to learn and not afraid to ask.
• Meticulous and responsible attitude.
• Able to function independently on tasks once trained on the job.
• Aspire to further upgrade.

The above criteria are not exhaustive. A*STAR may include additional criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret only shortlisted candidates will be notified.

Job Description

· Discharge the duties of a Workplace Safety and Health Officer (WSHO) in accordance to the Workplace Safety and Health (WSH) Act and the WSH (WSHO) Regulations.

· Develop/implement WSH management system and risk management plans pertaining to the research and general activities in the workplace.

· Develop/implement programmes to steer WSH culture, habits and norms of the organisation.

· Develop WSH training programmes and conduct safety trainings.

· Provide advice to Management with respect to changes in the Acts, Regulations, Codes of Practice and Standards, and make recommendations on any aspects of workplace safety & health and environment protection matters.

· Carry out WSH inspections and evaluate WSH non-compliance, unsafe work conditions and practices to identify WSH performance gaps.

· Facilitate the management of risk in the workplace, recommend, implement actions and review effectiveness of measures to improve WSH performance and control risks.

· Implement emergency preparedness and response plans and communicate plans to stakeholders.

· Conduct incidents investigations and make recommendations to address root cause of incidents.

· Act as the secretariat and facilitate the operations of the WSH committee.

· Work closely with cross-functional teams to integrate safety measures into operations and collaborate with external agencies when necessary.

Job Requirement

· Bachelor's Degree in Science, Engineering, Occupational Safety and Health, or related fields

· At least 7 years of proven experience in a similar WSH role.

· MOM registered Workplace Safety and Health Officer

· Extensive knowledge of Singapore's and International WSH Standards and Regulation.

· SCDF registered Fire Safety Manager, MOH certified Biosafety Coordinator will have an added advantage

· Self-driven, meticulous, analytical mindset with strong ability to multi-task

· Possess strong organisational and interpersonal skills

· Excellent oral and written communication skills

JOB DESCRIPTION

We are seeking to recruit a highly motivated Research Officer to support ongoing research into cancer antigen processing and presentation. Project involves supporting the team on biochemistry and immunology experiments, as well as simple bioinformatics.

JOB REQUIREMENT

• Bachelor’s degree or Diploma holder with at least 5 years relevant experience in biomedical science or immunology.
• Laboratory skills in basic biochemistry and cell biology.
• Curious, keen to learn and not afraid to ask.
• Meticulous and responsible attitude.
• Able to function independently on tasks once trained on the job.
• Aspire to further upgrade.

The above criteria are not exhaustive. A*STAR may include additional criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret only shortlisted candidates will be notified.