Roles & Responsibilities:

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying allergenomics and immunogenicity in the context of human health. The candidate will work on primary cells from cohorts and cell culture systems towards understanding allergenicity and immune responses. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Requirements:

• PhD Degree in Allergy, Novel foods, Food/Nutrition Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with at least 5 or more years of experience in allergenomics , immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job description

We are looking for highly-motivated and enthusiastic individuals with good AI/machine learning/deep learning skills to work on a new initiative on developing an AI approach for scoring of tumor epitope immunogenicity, aiming to better inform the cancer vaccine formulation and predict treatment response.

Successful candidate will work with a multidisciplinary team of bioinformaticians, immunologists, technical scientists, and oncologists to adopt, benchmark, and/or develop novel AI approaches which enable effective integration of multi-omics data (including whole-exome sequencing, RNA sequencing, proteomics, spatial-omics, immuno-peptidomic, and histological image data) for the prediction/ranking of tumor epitope immunogenicity. Successful candidate will have the opportunity to tap into a large pool of biomedical data of various forms and to establish a niche research area in AI-enabled (spatial) multi-omics cancer study.

Job requirements:

• Bachelor degree in the field of bioinformatics, computer science, computer engineering, or other data science intensive program. With expertise in at least one of the following areas: bioinformatics, data mining, machine and statistical learning, deep learning
• Possess minimum 5 years of relevant work experience
• Ability to work independently to translate research ideas into programs with efficient coding
• Basic knowledge on biology, data analytics, machine learning, deep learning
• Proficient in Python or R
• Deep learning programming skill is a plus
• Able to deliver under tight schedule
• Good team player with both research and data analytics ethics
• Good interpersonal and communication skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Project Overview

SMART CAMP (Critical Analytics for Manufacturing Personalized-Medicine) is a interdisciplinary research programme in Singapore (CREATE international research campus and innovation hub) and at the Massachusetts Institute of Technology (MIT). SMART CAMP addresses key technology bottlenecks in cell therapy manufacturing: (i) critical quality attributes of safe, effective cell therapy products; and (ii) integrated process analytics to monitor and modulate those attributes. While cell therapies are poised to transform healthcare for both the industry and the patient, there remain many outstanding scientific and technical challenges to significant global impact that this R&D programme addresses. This high-impact focus includes measurement and feedback control of processing parameters (process analytic technologies, or PAT) that contribute to cell viability and function during cell proliferation, and the measurement at intermediate and final steps of the cell product properties correlated with positive therapeutic outcomes (critical quality attributes, or CQA).

This interdisciplinary team comprises engineers, biologists, clinicians, manufacturing, and data analytics experts from multiple MIT academic units, and multiple Singapore-based universities, research centres of excellence, and hospitals who are experienced at translational demonstrations of technologies in safety-regulated industries such as cell therapies.

CAMP’s unique, enabling and cross-cutting capabilities include cell and clinical biology, microfluidics, real-time optics and spectroscopies, 3D-printed devices, process analytics, data analytics, and bioinformatics. This programme will demonstrate these approaches required of cell-based personalized medicine through three translational testbeds (three Flagship Projects), ultimately facilitating access for more patients to life-saving, approved cell therapies for currently intractable health challenges. These flagship projects will address allogeneic and autologous cell therapy products, including but not limited to cell sources including adult stem/progenitor cells and immune cells for treatment of specific cancers, tissue degeneration, and autoimmune diseases.

For information on SMART CAMP: https://camp.smart.mit.edu

Responsibilities

SMART CAMP research focuses on multiple immune cell types and targeted indications, including CAR-T cells for cancer therapeutics. Our experts in immunology at the basic and translational levels work on the development of both the cells’ critical quality attributes (CQA) and culture systems’ process analytic technologies (PAT). This Research Engineer / Senior Research Engineer will assist our researchers in laboratory organization, as well as in research and process development, including experiments related to:

• Immune cell culture and CAR-T cell manufacturing
• Immune cell isolation, activation, transduction, and expansion
• Immune cell characterization and profiling
• Clinical sample processing
• Lentivirus production
• Plasmid preparation

Requirements

• Bachelor of Science / Life Sciences / Bio-Engineering / Chem-Engineering Degree or Diploma.
• Research experience with aseptic cell culture is a must.
• Experience with cellular profiling assays, e.g. flow cytometry staining and analyses, gene and protein expression, cytotoxicity assays.
• Experience with molecular biology assays, e.g. molecular cloning and plasmid preparation.
• Experiece with bioreactors is an asset.
• Good organizational skills and time management.
• Good work ethic and intergrity, and ability to work well in a team.
• Able to communicate effectively in and present data to a multidisciplinary team of researchers with different training backgrounds.

To apply, please visit our website at: http://smart.mit.edu/careers/career-opportunities.

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.

Job responsibility

You will interact closely with SIgN Management, Principal Investigators and scientists, and external academic and industry partners and research institutions.

1. Promote SIgN research to Industry Partners. Facilitate SIgN researchers to communicate with industry partners on potential collaborations. Help to grow SIgN business activities by being proactive in creating new opportunities and new markets. Investigate on potential national and regional businesses.
2. Promote SIgN platform technologies to external academic and industry partners and research institutions for service engagements and collaborations through seminars, conferences, roadshows and exhibitions. Network with local and international partners and institutions to develop relations within Life Sciences and Immunology and promote use of SIgN platforms. Engage external partners and institutions in service agreements and collaborations.
3. Negotiate and administer Research Collaboration Agreements (RCA), Non-Disclosure Agreements (NDA) and Confidentiality Agreements. Review and file Technology Disclosures and work with HQ I&E on IP filing.
4. Coordinate with Project Management Office (PMO) on the management of industry and IAF-PP/IAF-ICP projects.

Job Requirements

Qualification & Field of Study: PhD or Masters in Life Sciences/Immunology/Molecular Biology or related fields, with relevant industry experience (preferred)

Min. Years of Experience: At least more than 5 years of business development or sales experience strongly preferred

Other Requirements (e.g. Skills, Competencies):

• Good team player with excellent interpersonal skills; independent and resourceful
• Excellent planning skills, well-organized and comfortable with outreach / promoting business partnerships
• Demonstrate strong delivery of commitments
• Excellent communication skills (written and verbal) with good presentation skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

We are seeking one (1) talented postdoctoral researcher to join the Synthetic Biology Translational Research Programme (TRP) at the National University of Singapore Yong Loo Lin School of Medicine. The Synthetic Biology TRP aims to develop novel genome editing tools, specifically by engineering existing CRISPRs, enhancing functionality through combinations with other enzymes, and screening desired mutants from the library via directed evolution.

The Research Fellow/s (RFs) will collaborate closely with the Principal Investigator and the research team to develop CRISPR tools. Appointments will initially be made on a 1-year contract, with the possibility of extension. PhD holders with no experience are welcome to apply.

The Research Fellow is expected to:

1. Rationally design protein engineering sites and conduct various library generation experiments (e.g., error-prone PCR, site saturation mutation) to create a library with high diversity;
2. Test CRISPR in various mammalian cell lines and measure indel efficiencies using Next Generation Sequencing tools;
3. Mentor research assistants, graduate, and undergraduate students;
4. Assist in any other duties delegated by the Principal Investigator and group leaders.

Qualifications

The applicant should:

1. Hold a PhD in Biotechnology, Biological Sciences, Biochemistry, or related disciplines;
2. Have extensive knowledge and hands-on experience on genetic parts assembly, pathway engineering, microbial strain engineering, fermentation, recovery and analytics of targeted metabolites;
3. Have the ability to design and perform experiments for microbial strain engineering, gene expression, protein expression, enzymatic assays, microbial fermentation, and product recovery;
4. Know how to work independently and in a team, have an investigative nature and a strong attention to detail;
5. Possess an established record of international publications

Remuneration will be commensurate to the candidate's qualifications and experience.

Informal enquiries are welcome and should be made to

Ms Suhana Sulaiman, at [email protected]

Formal application: Please submit your application, indicating job reference number and current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of 3 referees).

A*STAR Infectious Diseases Labs (A*STAR ID Labs) is seeking for a Research Officer to join us in our mission to be a leading centre of infectious diseases research. A*STAR ID Labs aims to develop a cohesive A*STAR response to drive and deliver translational infectious diseases research to better health and economic outcomes.

Job Description:

• To focus on bridging the knowledge gap of vector–pathogen-host interactions in mosquito-borne disease transmission. To understand the immune and pathogenic mechanisms during mosquito borne-virus infection to guide the development of targeted and effective control and treatment strategies

• Conduct laboratory experiments in vaccine/drug testing and perform data analysis for industry/research collaboration projects

• Work with patient cohorts and relevant models (both in vitro and in vivo) of infectious diseases

• Perform meticulous recordkeeping and able to draft delivery report to industrial partners

• Perform maintenance of inventory and procurement of laboratory consumables

• Ensure safe technical practices and procedures

Job Requirements:

• Bachelor Degree in Biomedical Sciences, Biochemistry, Life Sciences, Biological Sciences, Infectious Diseases, Microbiology, Immunology, Biochemistry or related field
• 1 to 2 years of relevant experience, fresh graduates are welcome to apply
• Experience with cell culture models, mouse models, animal studies, cell biology, flow cytometry, serological and molecular techniques, handling with BSL-2 and BSL-3 pathogens will be an asset
• Experience with industry project management
• Strong background in Microbiology, Immunology, Molecular Biology, Biochemistry, Genetics and Genomics
• Highly motivated and able to work independently
• Team player with good interpersonal skills
• Good spoken and written communication skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Assistant/Associate Professor

DEPARTMENT OF COMPUTER SCIENCE

Location: 510 Dover Road, Singapore

Description: Full-time Assistant Professor in Department of Computer Science, DigiPen Institute of Technology Singapore. We expect to make an appointment at the Assistant Professor Level or higher, commensurate with the candidate’s academic credentials and prior experience.

Responsibilities:

• While teaching some combination of the above subjects as determined by the selected candidate's unique synthesis of interests, he/she is also expected to teach general computer science subjects (such as operating systems, data structures, design and analysis of algorithms) at the university level. Other responsibilities include academic advising, undergraduate research advising, curriculum development, institutional service and appropriate scholarly activity.

Education and Experience Qualifications:

• PhD degree in Computer Science, Computer Engineering, or a closely related field.
• At least 4 years of industry or research experience in the field of study or a closely related area.
• Strong background in one or more following areas: C/C++ programming, Computer Graphics, Computer Architectures, Parallel Processing, Computer Networks, VR/AR, Computer Vision, Data Analysis, Distributed Computation, Cyber Security.
• Work/Teaching experience or exposure to one or more following areas: game/interactive-simulation, AI, machine learning, computer vision, data science, image processing, etc.
• 2D/3D graphic programming (OpenGL or DirectX) is an added advantage.
• A commitment to teaching excellence and scholarship is also expected.

Starting Date: Immediate

Salary: Salary is competitive and commensurate with experience and education.

Application: Review of applications will begin immediately and continue until the position is filled. For a complete application, please email a letter of interest, curriculum vitae, and statement of teaching philosophy, transcript of highest degree earned, and three letters of recommendation.

Electronic submission is required with documents in either Word or PDF format attached to an email and sent to:

Email: [email protected] with subject line “Full-time Faculty of Computer Science”.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

In 2021 the Singapore Hybrid-Integrated Next-Generation micro-Electronics (SHINE) Center was established.

One of the projects in SHINE focusses on developing the technology and demonstrators for Radio Frequency (RF) and microwave applications on flexible substrates.

As part of this project, we have a position for a research engineer with proven knowledge and experience in researching, designing, and testing of microwave passive and active circuits and subsystems.

Note: a design portfolio showcasing RF designs must be attached to the resume.

Qualifications

• Possess a PhD in Electrical Engineering
• Several years of experience in the simulation and design of microwave circuits and subsystems.
• Experience in the design of LNA, PA, mixer, control circuitry and antennas.
• Experience with tools such as ADS and HFSS.
• Experience with measurement of microwave circuits using VNAs.
• Able to work independently and in a team.
• Open to fixed-term contract.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Purpose

National Cybersecurity R&D Laboratories (NCL) is looking for hiring one creative cyber security R&D engineer who experienced on handling IT/OT/IoT program development, project operations, network security infrastructure of ICS and network system. The engineer will participate in NCL’s IT/OT Cyber Exercise, help to build NCL’s ICS environment/testbed and provide technical support for NCL’s VAPT developing project.

Job Description

• Deploy and maintain cloud-based computing system and network infrastructure.
• Design, setup, configure and troubleshoot network systems.
• Setup, configure, and troubleshoot server systems with different operating systems (Windows, Ubuntu).
• Perform a regular backup of data and application systems.
• Working with other parties (e.g., vendor, provider, ...) for the deployment and troubleshooting.
• Prepare and provide technical support to the end-users and other team members.
• Analyze critical logs, investigate, and troubleshoot technical issues.
• Implement and continuously update security patches for operating systems, servers and network devices to avoid security issues or attacks.
• Ongoing assessment of new threads and improve on computing security.
• Develop and deploy monitoring system for infrastructure.
• Ensure high availability of services through regular server and network maintenance.
• Perform and participate in capacity planning, redundancy planning and execution of Disaster Recovery Plan.

Qualifications

• Minimum three (3) years of relevant working experience.
• Experienced in Virtualization technologies (VMWare, VirtualBox, KVM etc).
• Experienced in complex secured network design, VPN and WLAN implementation.
• Has knowledge in network devices administration (e.g., Firewall, Router, VLAN, Switch etc).
• Familiar with Windows and Linux OS (Ubuntu, CentOS, Redhat etc).
• Able to configure secured Internet services with methods/protocol (e.g. HTTPS, SSH Tunneling, L2TP/IPsec etc).
• Familiar with data storage systems (e.g. FreeNAS, LTO, NFS etc.) and data backup operations on multiple File Systems.
• Enthusiasm for problem-solving and able to work in a fast-paced environment.
• Strong interpersonal skills with the ability to communicate effectively.
• Able to write automation script (e.g. Bash, Python, Ansible etc).
• Experience in private and public cloud environments (e.g., OpenStack, AWS etc).
• CCNA (Routing and Switching) or equivalent certification.
• Experience working with the open-source project.
• Able to write simple code in Python or Java.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

Research Group Overview:
Our research group at Faculty of Dentistry, National University of Singapore (NUS) laboratory is primarily focused on developing next-generation methods and multidisciplinary tools for dental and craniofacial research. In particular, we focus on combining the expertise in stem cells, tissue engineering, microfluidics, organ-on-a-chip, 3D bioprinting and non-invasive imaging for regenerative applications.

Responsibilities:
The multi-disciplinary research project focuses on developing microfluidic organ-on-a-chip models and 3D bioprinted constructs for dental applications. We are seeking a motivated and dedicated full-time, research assistant with an understanding of microfluidics, 3D culture, and 3D bioprinting process. This research will be primarily conducted at the Faculty of Dentistry, National University of Singapore (a multi-disciplinary, vibrant campus recognized for its outstanding reputation for translational research).

Primary responsibilities include:
- Microfluidic design and fabrication.
- Bioink formulation, and 3D bioprinting.
- Operate 3D bioprinters independently.
- Manage the optimization, development and characterization of microfluidic organ-on-a-chip devices.
- Manage the optimization, development and characterization of hydrogels, bioink formulation, 3D bioprinting, and tissue culture processes.
- Handling of stem cells, 3D culture, biomaterials and variety of molecular assays, histological and imaging techniques.

Other responsibilities include:
- Identify and coordinate with external vendors for resource procurement.
- Closely interact with multi-disciplinary collaborators including clinicians, biologists, and engineers.
- Rigorous documentation of experimental procedures and data.
- Communicate results and data in a timely and effective manner.
- Assist in project management and laboratory administration.
- Contribute to preparing manuscripts, research proposals, grant applications, and agreements.

Salary and benefits are commensurable to educational qualifications and working experience of the candidate.

Qualifications

• Bachelor’s/ Master’s degree in Dentistry, Bioengineering, or related field.
• 1-2 years’ working experience in microfluidics, bioink fabrication, 3D printing, and/or tissue engineering will be preferred. Longer working experience is expected for Bachelor’s candidates.
• Working experience in cell culture and handling of stem cells, molecular biology techniques will be preferred.
• Proficiency in 3D design, AutoCAD, COMSOL, or related applications would be preferred.
• Evidence of first-authored original research publications in the field of microfluidics, 3D bioprinting, and/or tissue engineering will be preferred.
• Strong organisational, literature review, administrative and problem-solving skills.
• Highly self-motivated, ability to work both as part of a team and independently with excellent presentation and communication skills (both written and verbal in English).

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

In 2021 the Singapore Hybrid-Integrated Next-Generation micro-Electronics (SHINE) Center was established.

One of the projects in SHINE focusses on developing the technology and demonstrators for Radio Frequency (RF) and microwave applications on flexible substrates.

As part of this project, we have a position for a research engineer with proven knowledge and experience in researching, designing, and testing of microwave passive and active circuits and subsystems.

Note: a design portfolio showcasing RF designs must be attached to the resume.

Qualifications

• Possess a Bachelor or Master degree in Electrical Engineering
• Several years of experience in the simulation and design of microwave circuits and subsystems.
• Experience in the design of LNA, PA, mixer, control circuitry and antennas.
• Experience with tools such as ADS and HFSS.
• Experience with measurement of microwave circuits using VNAs.
• Able to work independently and in a team.
• Open to fixed-term contract.

Roles & Responsibilities:

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying allergenomics and immunogenicity in the context of human health. The candidate will work on primary cells from cohorts and cell culture systems towards understanding allergenicity and immune responses. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Requirements:

• PhD Degree in Allergy, Novel foods, Food/Nutrition Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in allergenomics , immunology, molecular allergy and clinical immunology
• Experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

Job Description

The Tropical Marine Science Institute (TMSI) invites applicants for the above posts.

Duties and Responsibilities

• Regular field trips onboard a research vessel (may extend outside conventional office hours)
• Field trip planning and preparation
• Water profiling on research vessel using multiparameter optical sensors
• Water quality analysis in the lab using spectrophotometer
• Cell count in the lab under a microscope
• Cell culture and culture maintenance
• Post processing of data collected
• General maintenance of field trip equipment (preventive maintenance, timely calibration)
• General administrative duties (procurement etc.)

Salary will commensurate with qualifications and experience. The appointment will be for a period of 6 months and extendable depending upon the candidate’s performance.

Only shortlisted candidates will be notified.

Qualifications and Requirements

• Degree in Marine Science, Science or equivalent
• Good written and verbal communication skills in English

Job responsibility

You will interact closely with SIgN Management, Principal Investigators and scientists, and external academic and industry partners and research institutions.

1. Promote SIgN research to Industry Partners. Facilitate SIgN researchers to communicate with industry partners on potential collaborations. Help to grow SIgN business activities by being proactive in creating new opportunities and new markets. Investigate on potential national and regional businesses.
2. Promote SIgN platform technologies to external academic and industry partners and research institutions for service engagements and collaborations through seminars, conferences, roadshows and exhibitions. Network with local and international partners and institutions to develop relations within Life Sciences and Immunology and promote use of SIgN platforms. Engage external partners and institutions in service agreements and collaborations.
3. Negotiate and administer Research Collaboration Agreements (RCA), Non-Disclosure Agreements (NDA) and Confidentiality Agreements. Review and file Technology Disclosures and work with HQ I&E on IP filing.
4. Coordinate with Project Management Office (PMO) on the management of industry and IAF-PP/IAF-ICP projects.

Job Requirements

Qualification & Field of Study: PhD or Masters in Life Sciences/Immunology/Molecular Biology or related fields, with relevant industry experience (preferred)

Min. Years of Experience: At least more than 10 years of business development or sales experience strongly preferred

Other Requirements (e.g. Skills, Competencies):

• Good team player with excellent interpersonal skills; independent and resourceful
• Excellent planning skills, well-organized and comfortable with outreach / promoting business partnerships
• Demonstrate strong delivery of commitments
• Excellent communication skills (written and verbal) with good presentation skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The postdoctoral fellow will work closely with Asst. Prof. Patrick Rebentrost in the intersection of quantum algorithms and optimization, machine learning and/or finance. Sample topics include quantum algorithms for problems in supervised and unsupervised machine learning, algorithmic learning theory, and online learning, and quantum algorithms for financial problems such as portfolio optimization, pricing of financial derivatives, and hedging. The job will include the development of quantum algorithms in these areas, with provable quantum advantages and provable guarantees, when possible, in fault-tolerant models of quantum computation. The job will also include the development of algorithms that are easier to execute on available hardware such as variational and post-variational methods and quantum approximate optimization. Furthermore, the aim is to provide hardware implementations on available devices, comparisons between available hardware providers, and classical simulations of the quantum algorithms. For this purpose, the successful applicant will be granted significant independence concerning their research and receive generous travel funding. They will be expected to contribute to the group, for example by co-supervising student projects and assisting with outreach activities.

Qualifications

• Track-record working on quantum algorithms and/or quantum information. Candidates with expertise in other aspects of quantum computing such as quantum machine learning, near-term quantum algorithms, quantum approximate optimization are encouraged to apply.

• PhD in electrical engineering, computer science, physics or applied mathematics.

• Well-rounded research profile and ability to communicate research.

A Postdoctoral Scientist (Bioinformatician) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools Bioinformatician position

A Bioinformatician position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• Ph.D./ M.Sc. from a well-recognized institution with a strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics and Spatial-seq
• Experience with open-source bioinformatics tools
• Excellent analytical, technical, and problem-solving skills
• Knowledge with biostatistics highly desirable
• Self-starter who is comfortable working in a fast-moving interdisciplinary team
• Committed and able to work flexible hours
• Excellent communication, technical writing, and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:

1) Cipta NO, Chen Y, Loh YH#. H3.3 safeguards haematopoietic ERV-quilibrium Nature Cell Biology 2021(In press)

2) Gautam P, et al., Loh YH#. Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nature Communications 2021 Sep 24; 12, 5675 #As Corresponding author

3) Xing QR, et al., Loh YH#. Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility Sequencing. Science Advances. 2020 Sep 11. 6:37, eaba1190. doi: 10.1126/sciadv.aba1190

4) Xing QR, et al., Loh YH#. Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility. Genome Research 2020 Jul;30(7):1027-1039. doi: 10.1101/gr.257840.119.

5) Fang HT, et al., Loh YH#. Global H3.3 dynamic deposition defines its bimodal role in cell fate transition. Nature Communications 2018 Apr 18;9:1537

6) Yang BX, et al., Loh YH#. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell 2015163(1):230-45

7) Agarwal S, Loh YH, et al., Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464, 292-296.

8) Loh YH et al., Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 2006 38, 431–440.and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• PhD with strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent.
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics, and Spatial-seq.
• Experience with open-source bioinformatics tools.
• Excellent analytical, technical, and problem-solving skills.
• Knowledge of biostatistics highly desirable.
• Self-starter who is comfortable working in a fast-moving interdisciplinary team.
• Strong publication record in peer-reviewed journals.
• Committed and able to work flexible hours.
• Excellent communication, technical writing, and presentation skills.

Interested candidates are asked to send a cover letter detailing their research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]).

Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

The Institute of Molecular and Cell Biology (IMCB) is a premier research institute at A*STAR whose mission is to harness biology for transformational bio-therapeutics and diagnostics. In this role, you will be working with the IMCB researchers, grant agencies as well as A*STAR finance, councils, and the central research office to provide relevant grant-related support to the institute.

Job Description: the role includes, but is not limited to, the following:

• Ensure that all grant proposal submissions meet the requirements as set by the respective granting agency.
• Review annual progress reports and final reports for various grants and ensure that these are submitted on time.
• Attend to requests from the granting agencies pertaining to budget scrubbing, letter of award and other steps required for timely activation of new grants.
• Assist investigators with changes related to their grants (deviation/variation requests).
• Work closely with A*STAR research office, councils, and finance regarding ad hoc requests for grant-related data and pending tasks.
• Serve as the institutional admin and help with creation and activation of accounts for grant-related portals such as IGMS and iGrants.
• Tabulate and track the grants of the institute to ensure easy extraction of grant data whenever required.
• Promptly attend to grant-related queries from investigators.
• Define timelines for internal review and approval SOP of grant calls and communicate to researchers for grant applications.
• Monitor, report and analyse grant application activities as well provide timely updates to management on grant status.

Requirements:

• Minimum Bachelor’s degree, preferably in Life Science or equivalent.
• Preferably with at least 3 years of working experience.
• Experience and/or keen interest in work related to governance/ policy/ research administration, especially in the research & development sector, is an advantage.
• Good team player with excellent written and oral communication skills.
• Excellent time management skills.
• Meticulous, resourceful, able to multi-task and work independently.
• Able to work collaboratively with internal and external stakeholders across functional groups and levels.
• Interested in science and technology.
• Proficient in M365 and related applications.
• Prior experience in dashboard reporting and/or project management is a plus.

The Advanced Molecular Pathology Laboratory (AMPL) is a GLP laboratory at IMCB that provides key support to conducting cutting-edge biomedical research and development with a specific focus on laboratory animal histology and pathology. As part of the dynamic team in this laboratory, you will be responsible for providing services to support the needs of researchers. AMPL also provides veterinary diagnostic biopsy services to Singapore’s veterinary community.

Responsibilities:

• Operate histology laboratory equipment to provide histology services to research and the veterinary community.
• Provide high-quality technical services and expertise to researchers in the areas of complex animal tissue collection and processing procedures, as well as other laboratory procedures such as necropsy, tissue embedding, cryotomy, microtomy, histology slide staining, etc.
• Maintain equipment, reagents, and consumables, etc in good working order to ensure continuity of services.
• Involve in QA audit and/or archiving for GLP compliance.
• Handle routine laboratory administration and scheduled duties.

Requirements:

• Diploma in Life Sciences, Biological Sciences, or a related field.
• Good basic laboratory skills and manual dexterity.
• Meticulous and organized with an ability to multi-task.
• Good communication, interpersonal and analytical skills.
• Able to work independently and as well as with a team in a fast-paced environment.
• Willing to work in a service-based environment and provide technical advice and support Record/invoice maintenance/handling.
• Familiarity with histopathology techniques and GLP would be an advantage

Job Description
A Postdoctoral Immunologist (Scientist) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in immune cell types while developing novel tools and strategies for deriving desired cell types for therapeutic applications.

Applicants with a strong background in stem cells and immunology, including CAR-T cells, are invited to apply. Successful candidates must be highly motivated, have a passion for research and be able to work in an interdisciplinary environment.

Job Requirements:

• Ph.D. with a strong research background in Immunology
• Experience in stem cell expansion and characterization
• Excellent analytical, technical and problem-solving skills
• Knowledge of biostatistics highly desirable
• Self-starter who is comfortable working in a fast-moving interdisciplinary team
• Strong publication record in peer-reviewed journals
• Committed and able to work flexible hours
• Excellent communication, technical writing and presentation skills

Interested applicants can contact Dr Jonathan Loh (Principal Investigator) at [email protected].

AWARE, Singapore’s leading gender equality advocacy group, is seeking a passionate and dedicated Senior Programme Executive to join our CARE Services. This is your chance to directly impact the lives of women and survivors of sexual assault by supporting our crucial Women’s Care Centre (WCC) and Sexual Assault Care Centre (SACC).

More than just a job, this is a chance to:

• Make a tangible impact on the lives of women facing challenges
• Work alongside a team of professionals committed to gender equality
• Develop your skills in project management, advocacy and client support
• Contribute to innovative initiatives that support and protect women

Position: Senior Programme Executive
Department: CARE
Commitment: Contract, full time
Salary range: SGD$3,880-4,380
Starting date: Immediate

What you’ll do:

• Plan, coordinate, and execute CARE services, ensuring seamless operations and a client-centric approach
• Partner with service teams, volunteers, and stakeholders to build a supportive network for survivors
• Leading and supporting short-term and long-term initiatives that promote awareness, prevention, and policy change
• Provide emotional and practical support to clients, fostering healing and resilience
• Build and nurture relationships with internal and external partners to amplify impact

Are you the one we’re looking for?

• 3+ years of experience coordinating services or related projects/programmes
• Social work or related field qualifications and experience in the social sector (desired)
• Strong project management skills: analytical, organised, detail-oriented, with excellent report writing and documentation abilities
• Empathy, adaptability, and a collaborative spirit to thrive in a supportive and fast-paced environment
• Confidentiality, proficiency in MS Office and Google Suite, and excellent English communication skills (verbal and written)
• Strong belief in gender equality and the values of AWARE

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Please note that, due to the large number of applications, only shortlisted applicants will be contacted for an interview. If you have any questions about this position, please email [email protected].

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

• The Research Assistant will work closely with the Principal Investigator on several research projects on using machine learning in chemical and control engineering problems
• The Research Assistant will help to develop machine learning models for both theory and applications in advanced control systems

Job Requirements

• A Bachelor degree in a relevant area, e.g., Chemical Engineering, Control Engineering, Computer Science, Chemistry, etc.
• Experienced in machine learning, optimization and programming languages (e.g., python, Matlab, C++, etc)
• Any experience with 1) advanced control, 2) machine learning theory and applications, and 3) chemical engineering and chemistry is a plus

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: Master’s degree in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: At least 2 years’ relevant work experience

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Research Assistant will work closely with the Principal Investigator (PI) to design and build desirable microstructure to enhance mechanical properties of steels by additive manufacturing.

The job scope of this position is:

• Conducting literature reviews and understanding state of the art
• Planning and implementing experiments
• Developing simulation models to guide microstructural engineering
• Analysing the experimental and simulation data
• Writing progress reports and research papers

Qualifications

• Bachelors/Masters Degree in Materials Science or Mechanical Engineering
• Knowledge of metallurgy and microstructural engineering is highly required
• Expertise in microstructural characterisation techniques (e.g. TEM, EBSD and FIB) and mechanical testing
• Expertise in numerical simulations (e.g. phase field, FEM)
• Experience with metal additive manufacturing (e.g. powder bed fusion, directed energy deposition) will be advantageous
• Good publication record will be advantageous
• Self-motivated, good team player

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: PhD or equivalent in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: Fresh PhD graduates or PhD holders with < 5 years of experience in any/some of above fields

We are looking for a highly motivated research officer who is interested in developing next-generation DNA and RNA therapeutics for treating genetic diseases. The individual will be involved in a multi-disciplinary project to develop new technologies and tools for precision editing of nucleic acids. There will be opportunities to further develop techniques in protein engineering, directed evolution, and synthetic biology.

Responsibilities:

• Design and clone constructs for experiments
• Perform activity characterization in vitro and in mammalian cells
• Perform qPCR/RT-qPCR of mammalian cells
• Perform high-throughput sequencing library preparation
• Analyze data and communicate results of experiments to colleagues
• Maintenance of laboratory equipment and general laboratory supplies

Job Requirement

• Bachelor’s Degree in Biochemistry, Biotechnology, Bioengineering, Biological Sciences, Chemistry, Chemical Engineering, or other related fields
• Experience with mammalian cell culture and molecular biology techniques (eg. molecular cloning, PCR, gel electrophoresis, miniprep)
• Experience with flow cytometry, protein expression, bacteriophage, high-throughput sequencing, or bioinformatics will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work
• Ability to work independently and as part of a team
• Excellent communication (verbal and written) and presentation skills
• Curiosity to learn new knowledge and skills