Product Development and Management Executive

Working location: Pasir Panjang

Working Days: 5 days work

Working hours : 9am - 6pm
Salary Range: $3500 to $4200

Responsibilities:

• New product planning:

- Ideation: generate, develop, curate and prioritise ideas.

- Organise and define requirements based on market data and customer insights.

- Analyse industrial trends and do technology assessment.

- Evaluate scientific information to generate concepts for new product innovations; define product features.

- Define product competitive positioning and unique selling proposition (USP).

- Prepare and execute new product development (NPD) plan, ensuring processes occur within the

necessary timeframes to deliver a product to market.

- Align cross-functional Scrum team through Agile methodology.

• New product development (NPD):

- Source for contract manufacturers and liaise with engineers/ formulators to develop new product; be the main contact point with these suppliers for NPD/ formulation discussions.

- Review formulas and ingredient/ design statements for new product that is compliant with regulations.

- Conduct or work with contract manufacturer for efficacy assessment, literature review, product trial and testing.

- Work with contract manufacturers for safety assessment and stability study of products.

- Define critical attributes of final products, work with Quality team to finalise product master specifications and list of required lab tests.

- Work with Regulatory Affairs to finalise label text of products and with designer for packaging design.

- Technical resource for Regulatory Affairs, including providing technical document such as formula, raw material COA, efficacy, stability and safety information.

- Research market prices, create accurate product costing data and propose product pricing.

- Present new product for management’s review.

• New product introduction:

- Technical resource for Marketing, including providing technical brief or info sheet of product.

- Conduct product training as part of professional education to regional trainer/ marketing team and key leaders of salesforce.

• Post-launch product management:

- Reassess industry movement and re-evaluate competitor actions.

- Analyse product performance, profit and loss, and identify actions required.

- Manage incremental improvement for existing products.

- Liaise with contract manufacturers for necessary formula-related matters.

- React to necessary corrective and preventive actions (CAPA) raised by Quality.

• Contribute for and implement standard procedures (in compliance with industrial standards and QMS requirements) for any product development and management activities or as assigned.
• Perform other duties and projects as necessary to meet company goals.

Requirements:

• Degree in Nutrition, Pharmaceutical Science or relevant.

• Preferably with some experience in product development/ management in the dietary supplement and health food industry.

• Product/ project management experience; planning & time management experience.

• Travelling is expected.

WhatsApp: https://wa.me/6591044149 (Shermaine)

Siah Sze Ming Reg No: R24125414

The Supreme HR Advisory Pte Ltd EA No: 14C7279

Interested applicants are invited to apply directly at the NUS Career Portal

Your application will be processed only if you apply via NUS Career Portal

We regret that only shortlisted candidates will be notified.

Job Description

Most of the world now live in cities. Liveable, sustainable and resilient cities are needed to face the looming challenges of climate change, the next pandemics, ageing populations and technological, social and economic disruptions such as what we are currently experiencing.

NUS Cities is a multi-disciplinary, open and inclusive collaborating platform comprising the following three pillars: education, research and advisory.

Education: Educate the next generation of students as well as current practitioners to take an urban systems approach to plan, govern, build and manage cities, using a strong case-based approach taught by both practitioners and academics.

Research: Taking a systems approach tacking some of our biggest urban challenges, and in the process, gradually developing a Science of Cities.

Advisory: Provide strategic advisory services to organisations and cities. NUS Cities will also partner other universities and research institutions locally and internationally, as well as with industry partners worldwide.

NUS Cities hence draws on the varied talent and expertise of the University in its colleges, faculties and departments and centres of excellence to drive research to better plan, manage, and govern, high-density, high-growth, sustainable, resilient, and liveable cities through an urban systems approach and systems thinking.

The full-time appointment for this Research Fellow position is for a contract period of 1 to 2 years with the possibility of renewal.

Responsibilities 

• Establish and manage large databases.
• Interpret and analyse data
• Generate reports and presentation of data to relevant stakeholders
• Generate conference presentations and papers for submission to peer reviewed journals
• Collaborate across teams, contributing to multiple research projects at once
• Work closely with research PIs to develop new research ideas and ensure the successful and timely completion of the project(s)

Qualifications

• Doctorate degree
• Candidates interested in Cities and keen to delve into any of the below research modules are strongly encouraged to apply:
  1. Climate Resilience
  2. Ageing and Health
  3. Transportation and Land Use
  4. Urban Observatory
• At least three recent and relevant good journal papers on any of the below modules:
  1. Climate Resilience
  2. Ageing and Health
  3. Transportation and Land Use
  4. Urban Observatory
• Proficient in data analysis and visualisation tools in quantitative research or any relevant software and tools
• Keen interest in Cities
• Strong background with extensive experience leading research projects would be an advantage
• Excellent written and verbal communication skills
• Resourceful and self-driven
• Adaptable and able to multitask well with clear follow-through
• Demonstrated ability to work independently and thrive in a fast-paced environment
• Commitment to the ongoing development of a positive organisational culture
• Willingness to contribute to a learning environment

The role is based in Singapore.

Responsibilities

• Conduct research within assigned area of fixed income market coverage using information sources, including financial statements, earnings reports, published research, financial databases, corporate and management access
• Generate timely, and actionable bond investment ideas. Work with other members of the research team to evaluate a comprehensive range of bonds and bond funds
• Achieve and maintain a coverage list of bond issuers, and provide periodic research recommendations for bonds in the coverage list and newly issued bonds
• Communicate these investment ideas to the investing public and internal stakeholders through research reports, presentations, and other channels
• Contribute investment views and research in collaboration with the regional offices
• Contribute to the growth of the firm's fixed income business
• Undertake additional/ ad-hoc duties and projects assigned

Requirements

• Bachelor degree holder in a related discipline (accountancy, economic, finance or business administration), preferably with investment research experience
• Experience working with systems such as Bloomberg is desirable
• Good understanding of financial statements, bond mathematics, and macro drivers
• Demonstrated strong analytical skills, numerical capability, and attention to detail
• Excellent communication skills. Strong command of both spoken and written English. Mandarin speaking capability is a plus
• Demonstrated interest in and passion for investing
• Able to multi-task and meet constant deadlines

A*STAR Infectious Diseases Labs (A*STAR ID Labs) is seeking for a Research Officer to join us in our mission to be a leading centre of infectious diseases research. A*STAR ID Labs aims to develop a cohesive A*STAR response to drive and deliver translational infectious diseases research to better health and economic outcomes.

The candidate will be joining the Antimicrobial Chemical Biology Lab, a newly established group in A*STAR ID Labs focusing on the development of synthetic antimicrobial compounds for potential therapeutic applications. Scholarship opportunities will be available for those interested in pursuing further education at the master’s or PhD level.

Research projects will encompass various tasks such as:

• Chemical synthesis
• In vitro activity testing
• Understanding mechanisms of action
• In vivo efficacy evaluation.
• Support the team in lab operation
• Upkeep of consumables
• Safety oversight
• Labware procurement
• Documenting experimental procedures and results.

Job Requirements:

• Bachelor’s degree in microbiology, biomedical science, chemistry, chemical engineering, bioengineering, or related field
• Familiarity with basic microbiology (e.g., bacteria/fungi culture, agar plating, PCR) and chemistry (e.g., reaction setup, column purification, HPLC) lab techniques, programming, and/or common graphics software (e.g., Photoshop) will be advantageous.
• Highly motivated and passionate about scientific research
• Good spoken and written communication skills
• Team player
• Receptive and detail-orientated

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Product Development and Management Executive

Working location: Pasir Panjang

Working Days: 5 days work

Working hours : 9am - 6pm
Salary Range: $3500 to $4200

Responsibilities:

• New product planning:

- Ideation: generate, develop, curate and prioritise ideas.

- Organise and define requirements based on market data and customer insights.

- Analyse industrial trends and do technology assessment.

- Evaluate scientific information to generate concepts for new product innovations; define product features.

- Define product competitive positioning and unique selling proposition (USP).

- Prepare and execute new product development (NPD) plan, ensuring processes occur within the

necessary timeframes to deliver a product to market.

- Align cross-functional Scrum team through Agile methodology.

• New product development (NPD):

- Source for contract manufacturers and liaise with engineers/ formulators to develop new product; be the main contact point with these suppliers for NPD/ formulation discussions.

- Review formulas and ingredient/ design statements for new product that is compliant with regulations.

- Conduct or work with contract manufacturer for efficacy assessment, literature review, product trial and testing.

- Work with contract manufacturers for safety assessment and stability study of products.

- Define critical attributes of final products, work with Quality team to finalise product master specifications and list of required lab tests.

- Work with Regulatory Affairs to finalise label text of products and with designer for packaging design.

- Technical resource for Regulatory Affairs, including providing technical document such as formula, raw material COA, efficacy, stability and safety information.

- Research market prices, create accurate product costing data and propose product pricing.

- Present new product for management’s review.

• New product introduction:

- Technical resource for Marketing, including providing technical brief or info sheet of product.

- Conduct product training as part of professional education to regional trainer/ marketing team and key leaders of salesforce.

• Post-launch product management:

- Reassess industry movement and re-evaluate competitor actions.

- Analyse product performance, profit and loss, and identify actions required.

- Manage incremental improvement for existing products.

- Liaise with contract manufacturers for necessary formula-related matters.

- React to necessary corrective and preventive actions (CAPA) raised by Quality.

• Contribute for and implement standard procedures (in compliance with industrial standards and QMS requirements) for any product development and management activities or as assigned.
• Perform other duties and projects as necessary to meet company goals.

Requirements:

• Degree in Nutrition, Pharmaceutical Science or relevant.

• Preferably with some experience in product development/ management in the dietary supplement and health food industry.

• Product/ project management experience; planning & time management experience.

• Travelling is expected.

WhatsApp: https://wa.me/6591044149 (Shermaine)

Siah Sze Ming Reg No: R24125414

The Supreme HR Advisory Pte Ltd EA No: 14C7279

Software Engineer

5 days, 8.30pm- 5.50pm

Salary: $3500 -$4000

Location: Bedok office & client site

Job scope:

• To provide necessary post-project application software support to the client
• Troubleshoot, debug, enhance and optimise programs
• Develop new applications

Requirements:

• Candidate must possess at least a Diploma or Degree in Engineering, Computer Science/Information Technology or equivalent.
• Knowledge in Oracle PL/SQL, Oracle Pro-C programs, Unix ANSI C, visual basic.net using Visual Studio 17, Unix scripting
• At least 1 year relevant experience in end user and operation support

Chew Xing Shan Reg No: R22107044

The Supreme HR Advisory Pte Ltd EA No: 14C7279

WhatsApp: +65 83592812 [Shannon]

About EDDC EDDC is a national platform committed to developing innovative therapies that have the potential to transform patients" lives. Our research and development efforts are focused on understanding the underlying mechanisms of disease and translating these insights into effective treatments. We collaborate with both public sector and industry partners to translate scientific discoveries in Singapore’s biomedical and clinical research into innovative healthcare solutions.

Position Summary

We are seeking a highly motivated Junior Scientist/Scientist I to join our dynamic research team. The ideal candidate will have a strong foundation in chemical biology and thrive in an interdisciplinary research environment. The successful candidate will contribute to cutting-edge research focused on the design, synthesis, and application of small molecule probes for target engagement studies aimed at understanding disease mechanisms and advancing drug discovery.

Job Description

• Plan and execute research experiments under supervision and communicate results and conclusions in group meetings.
• Contribute to ongoing research and development projects in a fast-paced, collaborative environment.
• Maintain detailed and accurate lab notebooks to document research findings.
• Ensure proper upkeep of lab equipment, laboratory supplies, and maintain good housekeeping standards.

Job Qualifications

• A BSc in Chemical Biology is preferred. Applicants with a BSc in Chemistry, Biology, or related disciplines with relevant skill sets may also be considered.

Job Requirements

• Chemistry lab skills: Proficient in the synthesis and purification of compounds (using flash column chromatography, preparative HPLC), and compound characterization techniques (LCMS, HPLC, NMR).
• Biology lab skills: Proficient in cell culture, SDS-PAGE, Western Blot, pulldown and co-immunoprecipitation assays.
• Chemical Biology lab skills: Experience with Activity-Based Protein Profiling (ABPP), Affinity-Based Protein Profiling (AfBP), and chemoproteomics is a plus.
• Candidates without prior experience but with a strong desire and commitment to learn are also encouraged to apply.
• Passion for interdisciplinary research.
• A committed, self-motivated individual with a desire to learn new skills and take on new responsibilities.
• Excellent written and verbal communication skills.
• Strong interpersonal skills, team-oriented with a collaborative spirit and the ability to build relationships internally and externally.

Description:

The Laboratory of Genome Function, led by Dr. Tim Stuart (https://stuartlab.org) at the Genome Institute of Singapore is seeking a postdoctoral fellow interested in single-cell epigenomics. The successful candidate will lead the development of new algorithms and software for the analysis of single-cell genomic data, and lead the application of these methods to analyze and interpret new single-cell datasets.

Requirements:

• Ph.D. in computer science, mathematics, statistics, or a related field. Applicants with a degree in a biological field with strong programming and data analysis experience will also be considered.
• Experience in the analysis of single-cell data
• Ability to program in R, Python, C++, or Rust
• Machine learning experience
• Demonstrated ability to independently lead research projects
• Excellent oral and written communication skills
• Demonstrated ability to publish high-quality research

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Singapore Immunology Network (SIgN), A*STAR, is seeking to appoint an outstanding Senior Principal Scientist to carry out internationally competitive research in Autoimmunity and Inflammatory Diseases.

The research should investigate the pathophysiology of biological pathways and novel pathogenic mechanisms for debilitating disorders, with the aim to translate insights into innovative therapeutic approaches that lead to significant clinical benefits.

The successful candidate is expected to build and maintain a strong research programme that complements the existing programmes at SIgN, and to establish collaborations with the biomedical community and industry. The candidate will also mentor Junior PIs, postdocs and PhD students.

The Senior Principal Scientist position is equivalent to that of an Associate/Full Professor in the university system. The successful candidate can look forward to a competitive salary package and resources as well as a dynamic work environment. Although part of the research programme will be supported by core funding, the candidate is expected to expand his/her research activities by securing additional funds through the various grant schemes available in Singapore and abroad.

Job Responsibilities:

• To lead a research team to conduct experimental research in the areas of Autoimmunity and Inflammatory Diseases.
• To initiate and execute novel research projects, to translate research outputs into clinical or industrial collaborations
• To write up high impact research publications
• To mentor and provide support to junior researchers

Job Requirements:

• PhD in Immunology, Microbiology, Biomedical Sciences, or other relevant disciplines
• More than 8 years’ experience in independent research and leading a research group
• Strong lab-based research background in Immunology and Microbiology
• An excellent track record of research publications
• Excellent written and spoken communication skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Biological Resource Centre (BRC) is an AAALAC International accredited and bizSAFE Level 3 certified laboratory animal facility that provides high quality animal housing and animal support services. BRC is seeking an Associate (Administration) to join us to support the administrative duties.

Job Description

• Working closely with Finance and assist in billing of customers.
• Follow up with customers on overdue invoices.
• Communicate with customers/vendors via phone, email or personally and investigate and resolve customer queries.
• Performance of Good Receipt.
• Maintain and update booking system details when needed.
• Collation of information for Management.
• Assist with Management / Financial reporting.
• Preparation of presentation slides.
• Carry out other duties and tasks that may be assigned from time to time.

Job Requirements:

• Diploma in Business or Accountancy, or equivalent.
• Proficient in Microsoft Office (e.g. Outlook, Word, Excel, PowerPoint).
• Excellent interpersonal and communication skills, meticulous.
• Ability to break down tasks into deliverables and set realistic timelines for completion.
• Ability to work independently and collaboratively in teams.
• Excellent spoken & written communication skills.
• Knowledge of SAP system will be advantageous.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The Singapore Immunology Network (SIgN), A*STAR, is seeking to appoint an outstanding Senior Principal Scientist to carry out internationally competitive research in Autoimmunity and Inflammatory Diseases.

The research should investigate the pathophysiology of biological pathways and novel pathogenic mechanisms for debilitating disorders, with the aim to translate insights into innovative therapeutic approaches that lead to significant clinical benefits.

The successful candidate is expected to build and maintain a strong research programme that complements the existing programmes at SIgN, and to establish collaborations with the biomedical community and industry. The candidate will also mentor Junior PIs, postdocs and PhD students.

The Senior Principal Scientist position is equivalent to that of an Associate/Full Professor in the university system. The successful candidate can look forward to a competitive salary package and resources as well as a dynamic work environment. Although part of the research programme will be supported by core funding, the candidate is expected to expand his/her research activities by securing additional funds through the various grant schemes available in Singapore and abroad.

Job Responsibilities:

• To lead a research team to conduct experimental research in the areas of Autoimmunity and Inflammatory Diseases.
• To initiate and execute novel research projects, to translate research outputs into clinical or industrial collaborations
• To write up high impact research publications
• To mentor and provide support to junior researchers

Job Requirements:

• PhD in Immunology, Microbiology, Biomedical Sciences, or other relevant disciplines
• More than 10 years’ experience in independent research and leading a research group
• Strong lab-based research background in Immunology and Microbiology
• An excellent track record of research publications
• Excellent written and spoken communication skills

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Essential duties and responsibilities for this position include:

• The candidate will work together with a multidisciplinary research team to develop the quantum optical characterization setups, such as g(2) measurements, entangled photon measurements
• Optical characterizations of the fabricated quantum optical & nanophotonic devices.
• Data processing, programming, and automation of characterization setups
• Scientific dissemination (journal papers, conferences, and patents)

The detailed job requirements:

• A PhD Degree in physics/quantum optical characterization
• Strong publication track record
• Strong foundation knowledge in quantum optical characterization.
• Strong capability with optical alignment and optical characterization is an essential requirement.
• Self-motivated and passionate on research work
• Possess good critical thinking and problem-solving skills
• Good team player
• Excellent oral and written communication skills
• Applicants with no minimum work experience may apply

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The role will be part of the Singapore Aerospace Programme (SAP) team to manage research projects performed by A*STAR Research Entities for industry partners, manage programme activities and handle industry engagement activites.

Key responsibilities include:

Programme management

• Assist in the planning and execution of new project launches including the call for problem statements, workshops and proposal/technical reviews
• Monitor on-going projects through regular review meetings with research teams to ensure budget and deliverables are met
• Manage report submissions and variation requests
• Assist in the planning and execution of 6-monthly Programme Management Committee (PMC) meetings
• Work with teammates to ensure the smooth operations of the programme
• Support other office functions, e.g. hosting industry events

Stakeholder engagement and development

• Participate in meetings with SAP consortium members, industry stakeholders and public agencies
• Assist in the planning and execution of Singapore Airshow exhibition and hosting of Singapore Aerospace Technology Leadership Forum
• Facilitate the conceptualization and development of follow-on research initiatives beyond SAP
• Work with inter-division or inter-agency teams to drive aerospace industry development, develop industry transformation maps and aerospace roadmaps
• Coordinate industry engagement activities such as company visits to A*STAR and Airshow meetings and manage follow-up actions
• Nurture industry accounts to deepen research activities with A*STAR
• Engage Institutes of Higher Learning (IHLs) to jointly develop research ecosystem aerospace capabilities

Job Requirements

• Bachelor of Engineering, preferably in the field of aerospace or aeronautical
• 8 years of relevant experience, preferably in aerospace MRO or R&D and/or project management roles
• Strong communication skills
• Strong interpersonal skills
• Strong planning and analytical skills
• Result-oriented, resourceful and attentive to details
• Familiarity with the Singapore research ecosystem and grant call process will be an advantage

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

The role will be part of the Singapore Aerospace Programme (SAP) team to manage research projects performed by A*STAR Research Entities for industry partners, manage programme activities and handle industry engagement activites.

Key responsibilities include:

Programme management

• Assist in the planning and execution of new project launches including the call for problem statements, workshops and proposal/technical reviews
• Monitor on-going projects through regular review meetings with research teams to ensure budget and deliverables are met
• Manage report submissions and variation requests
• Assist in the planning and execution of 6-monthly Programme Management Committee (PMC) meetings
• Work with teammates to ensure the smooth operations of the programme
• Support other office functions, e.g. hosting industry events

Stakeholder engagement and development

• Participate in meetings with SAP consortium members, industry stakeholders and public agencies
• Assist in the planning and execution of Singapore Airshow exhibition and hosting of Singapore Aerospace Technology Leadership Forum
• Facilitate the conceptualization and development of follow-on research initiatives beyond SAP
• Work with inter-division or inter-agency teams to drive aerospace industry development, develop industry transformation maps and aerospace roadmaps
• Coordinate industry engagement activities such as company visits to A*STAR and Airshow meetings and manage follow-up actions
• Nurture industry accounts to deepen research activities with A*STAR
• Engage Institutes of Higher Learning (IHLs) to jointly develop research ecosystem aerospace capabilities

Job Requirements

• Bachelor of Engineering, preferably in the field of aerospace or aeronautical
• 5 years of relevant experience, preferably in aerospace MRO or R&D and/or project management roles
• Strong communication skills
• Strong interpersonal skills
• Strong planning and analytical skills
• Result-oriented, resourceful and attentive to details
• Familiarity with the Singapore research ecosystem and grant call process will be an advantage

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

About EDDC EDDC is a national platform committed to developing innovative therapies that have the potential to transform patients" lives. Our research and development efforts are focused on understanding the underlying mechanisms of disease and translating these insights into effective treatments. We collaborate with both public sector and industry partners to translate scientific discoveries in Singapore’s biomedical and clinical research into innovative healthcare solutions.

Position Summary

We are seeking a highly motivated Junior Scientist/Scientist I to join our dynamic research team. The ideal candidate will have a strong foundation in chemical biology and thrive in an interdisciplinary research environment. The successful candidate will contribute to cutting-edge research focused on the design, synthesis, and application of small molecule probes for target engagement studies aimed at understanding disease mechanisms and advancing drug discovery.

Job Description

• Plan and execute research experiments under supervision and communicate results and conclusions in group meetings.
• Contribute to ongoing research and development projects in a fast-paced, collaborative environment.
• Maintain detailed and accurate lab notebooks to document research findings.
• Ensure proper upkeep of lab equipment, laboratory supplies, and maintain good housekeeping standards.

Job Qualifications

• A BSc in Chemical Biology is preferred. Applicants with a BSc in Chemistry, Biology, or related disciplines with relevant skill sets may also be considered.

Job Requirements

• Chemistry lab skills: Proficient in the synthesis and purification of compounds (using flash column chromatography, preparative HPLC), and compound characterization techniques (LCMS, HPLC, NMR).
• Biology lab skills: Proficient in cell culture, SDS-PAGE, Western Blot, pulldown and co-immunoprecipitation assays.
• Chemical Biology lab skills: Experience with Activity-Based Protein Profiling (ABPP), Affinity-Based Protein Profiling (AfBP), and chemoproteomics is a plus.
• Candidates without prior experience but with a strong desire and commitment to learn are also encouraged to apply.
• Passion for interdisciplinary research.
• A committed, self-motivated individual with a desire to learn new skills and take on new responsibilities.
• Excellent written and verbal communication skills.
• Strong interpersonal skills, team-oriented with a collaborative spirit and the ability to build relationships internally and externally.

We are looking for a qualified individual to be involved in the below project. The candidate will work with a dynamic team to study the metabolic regulation of immune cells during the NASH to NASH-HCC progression.

Metabolic regulation of immune dysfunction during the progression of NASH to NASH-HCC

Description:

The lack of effective treatments for non-alcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma (NASH-HCC) underscores the need to understand the transition from NASH to NASH-HCC. Identifying why some NASH patients develop HCC while others do not is a significant challenge, with growing evidence indicating that immune dysregulation plays a crucial role in this progression. The interstitial space, where cells receive nutrients and signals, significantly impacts immune function, suggesting that understanding the liver"s metabolic environment could reveal how immune cells behave during NASH progression to HCC. By profiling interstitial fluid metabolism and single-cell transcriptomics, the team aims to understand the metabolic regulation of the immune landscape in NASH to NASH-HCC progression. Using a high-fat, high-fructose, and high-cholesterol dietary mouse model that mirrors human progression, the team will study the metabolic and immune changes leading to NASH-HCC. In addition, the team’s preliminary findings show immune alterations and reduced levels of the bile acid hyodeoxycholic acid (HDCA) during NASH-HCC transition. The identified candidate will also test the potential of HDCA in preventing NASH to HCC transition, and further explore HDCA"s effects on immune cells.

Job responsibilities:

• Conduct in vitro wet lab experiments (e.g. cell culture, molecular biology and assays, microscopy etc)
• Conduct in vivo animal experiments (e.g. diet/treatment regimes, body weight & composition analyses, metabolic phenotyping, blood sampling etc)
• Conduct end-point animal experiments (e.g. terminal blood collection, tissue collection and sample preparation, whole tissue/organ imaging, serum measurements etc)
• Analyze collected data and maintain accurate monitoring and reporting of experimental set-up, results and research findings
• Interact and collaborate with and assist other researchers and collaborators on related projects
• Communicate regularly with supervisor and join discussions with Principal Investigator and rest of the lab to discuss scientific progress and direction
• Assist in the preparation of grant applications and grant process reports
• Present findings both orally and in written form via presentations and publication in peer-reviewed journal
• Assist in the preparation of figures and manuscripts on the research projects for publication in peer-reviewed journals
• Contribute to other program-related projects and organizations and with the general scientific community across A*STAR

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

Job Description

A scientist or senior scientist position is available at the Functional Proteomics Laboratory for setting up, developing methods and performing targeted and untargeted metabolomics experiments. You will work on mass spectrometry-based identification of small molecule binders of RNA and small molecule metabolomics projects.

• Develop and run standardized protocols for untargeted metabolomics (or targeted metabolomics panels) for small molecule analysis.
• Design workflows and optimize analytical methods for performing targeted/untargeted metabolomics experiments for different sample mediums (Plasma/Urine/Tissue).
• Work with different collaborators and lead projects for small molecule metabolomics analysis on various sample types.
• Conceptualise, design and develop metabolomics assays for quantification of small molecules.
• Write and present research findings for conferences and publications.
• Contribute to project management, provision of guidance to junior researchers, including research officers.

Job Requirements

• Ph.D. degree in Molecular Biology, Biochemistry, Chemical Biology, Analytical Chemistry or a related discipline.
• Strong expertise in small molecule mass spectrometry metabolomics (preferred untargeted small molecule metabolomics expertise) with good publication record.
• Experience with liquid chromatography and mass spectrometry instrumentation, sample preparation techniques, data acquisition and interpretation.
• At least 2 years working experience in the field of metabolomics will be preferred.
• Proficiency in data processing, data analysis and interpretation will be advantageous.
• Responsible, organized, able to work independently and with a team.
• Good communication skills for scientific presentation and scientific writing.
• Optional: Prior experience with R or other data analysis tools

A Research fellow position is available in Dr. Anand Andiappan Laboratory at the Singapore Immunology Network (SIgN). The successful candidate will support the research work that focuses on studying inflammaeing in the context of skin aging in Asian populations.

The candidate will work on primary cells from cohorts and cell culture systems towards understanding functional immune responses in skin immune interactions and recapitulating them in in-vitro and ex-vivo systems. Additional work involves cellular and stimulation assays with flow cytometry and FACS analysis along with imaging by microscopy, and associated data analysis with statistical tested.

Duties will include managing safety in the laboratory, creating Standard Operating Procedures (SOPs) and laboratory risk assessments, maintaining laboratory inventories, perform other laboratory administrative duties and operations such as ordering and tracking laboratory budget.

Job Requirements:

• PhD Degree in Skin Immunology, Life sciences, Biomedical sciences, Molecular Biology, Biotechnology or equivalent
• Preferably with experience in dermatology, immunology, molecular allergy and clinical immunology
• At least 2 years experience with human and mouse blood/tissue sample handling and in vitro cell culture and processing (e.g. isolation of specific immune cell populations, differentiation and activation assay)
• Experience with flow cytometry analysis for different immune cell populations and functional immune assays
• Highly motivated to work in research laboratory and able to perform tasks independently
• Precise, detailed-oriented and able to follow complex protocols
• Willing to learn new experimental procedures and troubleshoot assays
• Good team player with good interpersonal skills
• Good spoken and written communication skills

Please submit your application with a cover letter summarizing your research experience.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Requirements:

• 1-2 years of experience in IOS/Android App development.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Flutter, React, Dart and native programming language.
• Proven experience in building mobile applications for Android and iOS.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Responsibilities

The lab of RNA in Disease and Translational Technologies at the Institute of Molecular and Cell Biology, A*STAR, Singapore is seeking to recruit a highly motivated Scientist or Senior Scientist to join a team developing a ribozyme-based RNA platform for potential translational and/or clinical applications.

The work will involve both in vitro and in vivo techniques, including molecular biology (RNA design, in vitro transcription, cell-free RNA assays, RT-qPCR, molecular cloning), cell biology (cell culture, cell transfection, flow cytometry, antisense oligonucleotides and RNAi, CRISPR), high-resolution imaging techniques, and experiments in mouse models (e.g. transgenesis, in situ hybridization and immunohistochemistry, imaging and functional analyses)

Requirements

• Minimum Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Genetics, Neuroscience or a related discipline.
• The successful candidate should have strong expertise in RNA biology, cell biology, biochemistry and molecular biology techniques, a strong publication record that includes a first author research paper, and strong scientific writing skills.
• They should be creative, highly motivated, conscientious and be able to work independently, with good organisational, verbal and interpersonal skills. Our lab is collaborative and interdisciplinary, and the successful candidate should be able to work effectively and harmoniously in a diverse team.
• As a Scientist, candidate will also be expected to mentor and train students and Research Officers.

We are seeking a passionate and skilled Flutter Developer to join our dynamic team. The ideal candidate will have a strong understanding of Flutter development, be proficient in Dart programming, and have experience building high-quality, scalable mobile applications.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications using Flutter.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Job Requirements:

• At least 5 years relevant experience in Flutter development. Candidates with no experience and possess relevant technical knowledge may apply.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Dart programming language.
• Proven experience in building mobile applications for Android and iOS using Flutter.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description:

• Support procurement process at DxD Hub, ensuring technical and policy compliance as well as value-for-money.
• Structuring requirements for procurement process: Translate purchase requests from technical team to online procurement systems.
• Perform and/or support activities throughout procurement process. Example activities include creating internal approval memos and justification, preparing external documents (e.g. Invitation to Quote, Tenders).
• Support proposal evaluation: work with users to perform structured assessment of vendor proposals and recommend proposal to award.
• Partner with executives in other functions including Procurement and Finance to ensure efficient operations.
• Collate and track data to support analysis, including maintaining databases and hard copy records.
• Ensure that database is updated in a timely and accurate manner.
• Provide general administrative and clerical support to DxD Hub Team ensuring safe and comfortable DxD Hub operations.
• General administrative and clerical support to DxD Hub Team.
• Manage and monitor inventory of office and pantry supplies and re-order as needed.
• Track non-scientific equipment and assets (e.g. video conferencing system, furniture) and work with vendors for maintenance.
• Monitor facilities vendors (e.g. cleaning, telecom) to ensure a comfortable office environment for staff including light clean-up as needed.
• Work closely with SpIA and HR for the issuance of staff card for new hires and ensure that the staff has access to all DxD office sites.

Job Requirements:

• Diploma holder with a certificate in professional secretarial skills/ finance.
• Minimum 2 years of relevant experience in similar capacity.
• Experience in purchasing of biomedical consumables and equipment would be an advantage.
• Proficient in MS Office Applications, including Word, Excel, PowerPoint, and Outlook.
• A team player with excellent interpersonal, communication and organisational skills.
• Able to communicate effectively, multi-task, and work in a dynamic environment.
• Well organised and good written communication skills.
• Awareness of workplace health and safety would be an advantage.
• Meticulous and able to work independently in a fast-paced environment.
• Individual who is self-motivated, and results driven.
• Proactive and takes ownership of projects.
• Adaptable and able to work under pressure.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

We are seeking a passionate and skilled Flutter Developer to join our dynamic team. The ideal candidate will have a strong understanding of Flutter development, be proficient in Dart programming, and have experience building high-quality, scalable mobile applications.

Job Responsibilities:

• Design and develop high-quality, scalable, and maintainable mobile applications using Flutter.
• Collaborate with cross-functional teams to define, design, and ship new features.
• Ensure the performance, quality, and responsiveness of applications.
• Identify and correct bottlenecks and fix bugs.
• Help maintain code quality, organization, and automatization.
• Stay up-to-date with the latest trends and technologies in mobile development.

Job Requirements:

• At least 2 years relevant experience in Flutter development. Candidates with no experience and possess relevant technical knowledge may apply.
• Bachelors degree in Computer Science, Information Technology, or a related field.
• Strong knowledge of Dart programming language.
• Proven experience in building mobile applications for Android and iOS using Flutter.
• Understanding of the full mobile development life cycle.
• Familiarity with RESTful APIs to connect mobile applications to back-end services.
• Strong understanding of design principles and user interface guidelines.
• Excellent problem-solving skills and ability to work in a team environment.
• Good communication and interpersonal skills.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

Job Description:

• Support procurement process at DxD Hub, ensuring technical and policy compliance as well as value-for-money.
• Structuring requirements for procurement process: Translate purchase requests from technical team to online procurement systems.
• Perform and/or support activities throughout procurement process. Example activities include creating internal approval memos and justification, preparing external documents (e.g. Invitation to Quote, Tenders).
• Support proposal evaluation: work with users to perform structured assessment of vendor proposals and recommend proposal to award.
• Partner with executives in other functions including Procurement and Finance to ensure efficient operations.
• Collate and track data to support analysis, including maintaining databases and hard copy records.
• Ensure that database is updated in a timely and accurate manner.
• Provide general administrative and clerical support to DxD Hub Team ensuring safe and comfortable DxD Hub operations.
• General administrative and clerical support to DxD Hub Team.
• Manage and monitor inventory of office and pantry supplies and re-order as needed.
• Track non-scientific equipment and assets (e.g. video conferencing system, furniture) and work with vendors for maintenance.
• Monitor facilities vendors (e.g. cleaning, telecom) to ensure a comfortable office environment for staff including light clean-up as needed.
• Work closely with SpIA and HR for the issuance of staff card for new hires and ensure that the staff has access to all DxD office sites.

Job Requirements:

• Diploma holder with a certificate in professional secretarial skills/ finance.
• Minimum 5 years of relevant experience in similar capacity.
• Experience in purchasing of biomedical consumables and equipment would be an advantage.
• Proficient in MS Office Applications, including Word, Excel, PowerPoint, and Outlook.
• A team player with excellent interpersonal, communication and organisational skills.
• Able to communicate effectively, multi-task, and work in a dynamic environment.
• Well organised and good written communication skills.
• Awareness of workplace health and safety would be an advantage.
• Meticulous and able to work independently in a fast-paced environment.
• Individual who is self-motivated, and results driven.
• Proactive and takes ownership of projects.
• Adaptable and able to work under pressure.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.