Acoerela Pte. Ltd. is seeking a Research Officer
Eligibility
- The candidate must have a minimum of Honours degree or its equivalent in biology related fields
- The candidate must be a Singapore citizen or Singapore Permanent Resident
Preferred requirements
- Independent and motivated individual with a passion for scientific research
- Ability to organise and complete work assignments in a timely manner
- Effective problem solving and communication skills
- Good Laboratory Practices
- Practical experience and/or knowledge of
- Biological chemistry, cell biology, or biochemistry
- Characterization techniques including absorbance/fluorescence measurements, dynamic light scattering, flow cytometry or fluorescent microscopy
- Quality Control procedure
- Cell culture and aseptic techniques
- Knowledge of working with nanoparticles is highly sought after
- Microsoft office
Coverage
- The position is tenable for one year with option for renewal
- Monthly salary with CPF contribution, annual bonus, performance bonus and other benefits, if eligible
- Annual increase in stipend/salary is subjected to good performance
Bond and duties
- There is no bond attached to the sponsorship.
- Need to carry out research work, routine QC/QA and/or other administration work assigned by the supervisor
Research overview
Fluorescent labels are essential tools in many branches of life science research. They provide high sensitivity for detection and are non-destructive to the target samples. Traditionally, fluorescent labeling is achieved by adding a chromophore to biomolecules such as proteins or nucleic acids. Conjugated oligoelectrolytes (COEs) are emerging as a new class of fluorescent molecules used to label cells and other specimens for non-invasive fluorescence imaging directly.
COEs are defined by a linear hydrophobic conjugated backbone with polar ionic pendants at both terminals. They were firstly synthesized in Prof. Bazan’s group as two-photo absorption chromophores and later found to have biological applications. COEs are membrane intercalating molecules that span the lipid bilayer. The spontaneous intercalation into membranes from aqueous media results in significant increases in fluorescence emission. By tuning the molecular framework in the conjugated core of COE, COEs characterized by different emission wavelengths can be achieved, thereby gaining access to a range of different colours for fluorescent labelling.
About the Company and the role
Acoerela Pte. Ltd. is a spin off from NUS that is commercializing COEs for use as dyes in life science. This role aims to determine the labelling efficiency of various COE dyes across different biological samples, including but not limited to mammalian cells, bacteria of different membrane structures, and extracellular vesicles. The characterization and applications for these COE-labelled samples will also be investigated via different fluorescence-based techniques such as confocal microscopy, flow cytometry, and in vivo fluorescent imaging. This role will also include developing products for use as standards in fluorescent applications.
Supervisor
Ankitha Channabasappa, Scientific Technical Development Manager, Acoerela Pte. Ltd.
Application Procedure
- Email your resume to [email protected] with the subject RESEARCH OFFICER
- If your qualifications and experience do match the job requirements, a member of our recruitment team will contact you to discuss your candidature in more detail
- Shortlisted candidates need to go through three rounds of interviews (with academic supervisor, industrial supervisor, company HR)
