Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: Master’s degree in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: At least 2 years’ relevant work experience

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Research Assistant will work closely with the Principal Investigator (PI) to design and build desirable microstructure to enhance mechanical properties of steels by additive manufacturing.

The job scope of this position is:

• Conducting literature reviews and understanding state of the art
• Planning and implementing experiments
• Developing simulation models to guide microstructural engineering
• Analysing the experimental and simulation data
• Writing progress reports and research papers

Qualifications

• Bachelors/Masters Degree in Materials Science or Mechanical Engineering
• Knowledge of metallurgy and microstructural engineering is highly required
• Expertise in microstructural characterisation techniques (e.g. TEM, EBSD and FIB) and mechanical testing
• Expertise in numerical simulations (e.g. phase field, FEM)
• Experience with metal additive manufacturing (e.g. powder bed fusion, directed energy deposition) will be advantageous
• Good publication record will be advantageous
• Self-motivated, good team player

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: PhD or equivalent in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: Fresh PhD graduates or PhD holders with < 5 years of experience in any/some of above fields

We are looking for a highly motivated research officer who is interested in developing next-generation DNA and RNA therapeutics for treating genetic diseases. The individual will be involved in a multi-disciplinary project to develop new technologies and tools for precision editing of nucleic acids. There will be opportunities to further develop techniques in protein engineering, directed evolution, and synthetic biology.

Responsibilities:

• Design and clone constructs for experiments
• Perform activity characterization in vitro and in mammalian cells
• Perform qPCR/RT-qPCR of mammalian cells
• Perform high-throughput sequencing library preparation
• Analyze data and communicate results of experiments to colleagues
• Maintenance of laboratory equipment and general laboratory supplies

Job Requirement

• Bachelor’s Degree in Biochemistry, Biotechnology, Bioengineering, Biological Sciences, Chemistry, Chemical Engineering, or other related fields
• Experience with mammalian cell culture and molecular biology techniques (eg. molecular cloning, PCR, gel electrophoresis, miniprep)
• Experience with flow cytometry, protein expression, bacteriophage, high-throughput sequencing, or bioinformatics will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work
• Ability to work independently and as part of a team
• Excellent communication (verbal and written) and presentation skills
• Curiosity to learn new knowledge and skills

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Dr Gloryn Chia on developing cancer vaccines.

We are seeking a highly motivated Research Fellow with expertise in immunology. Our team aims to leverage on stem cell biology (Sagi, Chia et al., Nature 2016; Chia et al., Nature Cell Biology 2019; Chia et al., Nature Cell Biology 2017) and cell engineering to develop alternative immunotherapeutic strategies to target refractory cancer types. The candidate will work closely with clinicians to establish empirical platforms for identifying and validating cancer vaccine candidates, and to translate research findings into clinical practice. Also, the candidate will be involved in the assessment and development of vaccines against novel antigens for the treatment of cancer and other human diseases. The successful candidate will need to independently design and execute experiments, troubleshoot issues, interpret results and give project updates. Highly motivated individuals with a passion for advancing personalized medicine are encouraged to apply.

We provide a highly competitive remuneration package that commensurates with the qualifications and relevant experience of the successful candidate.

The laboratory is supported by generous funds from the National Research Foundation Fellowship (NRF 2020). For more information, please visit http://pharmacy.nus.edu.sg/gloryn-chia-laboratory/

Qualifications

The main responsibilities of the position include:
Performing and designing experiments

• Qualifications / Discipline:
PhD in Immunology or relevant disciplines

• Skills: Cell culture, molecular cloning, etc.

• Experience:
Research experience

Job Highlights:

• Competitive Salary Package & Excellent Employee Benefits
• Opportunities for Growth & Development
• Flexible Hybrid Working Arrangement

Main Purpose of Job:

• The Regional Research & Development (R&D) Manager will be primarily responsible to oversee and manage the full spectrum of R&D Division activities in Yanmar International Singapore Pte Ltd (YIS).
• To establish a close partnership with regional R&D teams in the designated overseas companies and with Japan headquarters (HQ) R&D Senior Management to ensure contribution of regional R&D initiatives.

Responsibilities:

• Develop the regional R&D strategy plan as part of HQ’s R&D strategy planning process and provide input on business priorities and challenges faced regionally.
• To work with the HQ R&D Division and regional Corporate Planning departments to ensure that R&D programs formulated supports the business needs, and act as a change advocate to help drive these initiatives into each business.
• Determine regional short-term and mid-term R&D roadmap and strategies in accordance with the HQ’s R&D strategies and business requirements.
• Oversee all research, planning, and implementation of new programs and protocols for the designated overseas companies including the development of new products.
• Coordinate with overseas R&D departments on the implementation of activities related to Product Development and Product Testing areas, as well as for the improvement of existing products and technologies.
• Oversee all Product Testing and Product Development initiatives that are carried out in overseas companies.
• Work with relevant divisions to ensure successful developmental processes for new products and programs, from initial planning to implementation and production, as well as follow-up after implementation.
• Assess the scope of research projects and ensure the regional projects will be completed on time and within approved budgets.
• Develop and implement regional R&D policies and procedures.
• Provide overall R&D governance for the designated overseas companies.
• Plan, manage and monitor all R&D budget matters in the designated overseas companies.
• Functional management of all R&D staffing ensuring maximum productivity and responsibility for staff development.

Supervisory Responsibilities:

• The Regional R&D Manager will be responsible to lead the R&D Division in YIS to accomplish all divisional goals and responsibilities.

Competencies Required:

• Excellent verbal and written communication skills. Ability to express oneself clearly in conversations, interactions and business writing with others.
• Develop and maintain good relationships with employees at all levels within the company and also with external parties (e.g. partners, clients, vendors etc.).
• Ability to strategically analyze the current position or situation by considering internal and external trends, stakeholder requirements, and competitors.
• Detailed, well-organized and able to multi-task and manage multiple projects at the same time, prioritizing required actions accordingly to meet required deadlines.
• Strong drive to remain focused, self-motivated and committed to completing or achieving tasks.
• Professional attitude and projection of a professional company image, in line with the Company’s core values.
• Must be able to travel overseas if required.

Experience Required:

• Bachelor’s or Master’s degree in Engineering, Business Administration/Management or related technical field.
• Minimum 8 years’ experience in regional R&D strategic planning/delivery management and project management, especially in process improvement, best-practice, and partnership with business leaders.
• Minimum 5 years’ working experience in people management especially in a management position.
• Good understanding of R&D practices and regulatory compliance in Asia Pacific.
• Prior experience in Manufacturing or Machinery Industry will be an added advantage.
• Prior experience in working in a multi-cultural environment is an added advantage.
• Fluent in both spoken and written English. Ability to speak and understand Japanese language is an added advantage.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Mechanobiology Institute, Singapore, is a multidisciplinary institute committed to developing new paradigms for biomedical research by focusing on the quantitative analysis of dynamic functional processes. Through quantitative biophysical approaches, we address major problems in biomedical sciences, including pathogenesis (from bacterial to cancer), tissue regeneration, and function.

Asst. Prof. Chan seeks a highly motivated individual to join his laboratory on Mammalian Development and Tissue Hydraulics as a postdoctoral fellow at the Mechanobiology Institute in the National University of Singapore. This position is offered under a highly interdisciplinary project that aims to understand macrophage-environment mechanochemical crosstalk during ovarian ageing.

Project Scope

The candidate will investigate the mechanobiological principles by which cell mechanics, ECM remodelling and inflammation drive fibrosis during ovarian ageing. The selected candidate will combine an ex vivo approach with advanced imaging, omics and biophysics to explore how tissue-resident macrophages respond to age-associated changes in matrix stiffness and composition, and how this in turn drives macrophage-mediated fibrosis. To learn more, please refer to the relevant publication by the lab: Front Cell Dev Biol. 2022; 10: 1038107.

Qualifications

Candidates should hold a PhD, or be in the final stages of their PhD, in one of the disciplines below:

• Tissue engineering
• Cell/ molecular/ tissue biology
• Cellular biophysics

Skills and Experiences

• Confocal bioimaging and quantitative image analysis
• Some experience in primary cell culture
• Experience in mice work would be advantageous
• Highly motivated and independent; open to feedback
• Excellent written and interpersonal communication skills; able to work well in an interdisciplinary team

Applications should include a description of their research interests, their CV and the names and contacts of 2-3 references in their application. The application deadline is 15 March 2024.

Job Responsibilities

• Lead, manage and implement end-to-end projects related to IT Infrastructure (including Cloud) according to project governance.
• Work with internal business and other stakeholders to understand and analyse business requirements, translate business IT requirements to technical requirements.
• Work out full-scaled and precise proposal with technical solution team, coordinate and communicate resource and define clear roles with all project resources.
• Work onsite in a bank and manage vendors to ensure project delivery within schedule & budget and expected quality.
• Manage the communication and arrangement internally and externally.

Job Requirements

• Bachelor’s degree in information technology, Computer Science or equivalent.
• Min. 8 years of experiences as Project Manager in a bank in IT Infrastructure.
• Experience in Cloud related project implementation.
• Experience of Vendor management.
• Knowledge of IT security, Risk Management and Security Control.
• Ability to handle multiple projects concurrently.
• Possess good initiative and proactive in approach.
• Excellent communication, presentation and interpersonal skills.
• Project Management certification (e.g., PMP, PRINCE 2) is a plus.
• Experience in Agile Project Management methodology is an advantage.
• Certification in ITIL and Cloud related is a plus.
• Knowledge of IT regulation in APAC countries.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof. Noah Lim under a project on Multicomponent Formulations For Coatings That Increase The Shelf Life of Perishable Goods.

The main responsibilities of the position include:
1. Participate in project operation.
2. Fruit market survey.
3. Screening and optimization of edible components for fruit extension shelf-life coating formulation.
4. Structure analysis of formulated coating/thin film

Qualifications

• Qualifications / Discipline: Bachelor Degree in Chemistry/Materials/Food Science and Technology.

• Skills: SEM, Confocal Microscope, FTIR, HPLC, sensory evaluation, etc.

• Experience: With expertise in food science, formulation development, polymer science, biomaterials.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

• Polymer Synthesis
• Nanomaterials Synthesis
• Self-Assembly, particularly crystallization-induced self-assembly
• Mentor PhD students
• Draft grant proposals
• Oversee lab safety

Job Requirements

• PhD degree in chemistry, materials science and engineering, electric and computer engineering, or chemical engineering.
• Ample research experience in polymer synthesis (particularly ATRP, RAFT and ROMP), nanomaterials synthesis, and self-assembly of polymers and nanomaterials into hierarchical structures
• Solid background/experience in materials for self-assembly and catalysis.
• Excellent communication and writing skills
• Strong publication record
• Prior undergraduate and master students mentoring experience

Job Description

The Visiting Professor(VP) is expected to:

1. Manage and drive one or more translational research projects, design and execute experiments, assimilate and interpret results;
2. Solve scientific problems, think independently, and suggest creative solutions;
3. Write papers together with the PI for publications or patents and collaborations;
4. To provide advice and networking connectivity for the strategic planning and success of Synthetic Biology Translational Research Program;
5. Provide research strategic directions to researchers and mentorship to PI, researchers, postgraduate and undergraduate students.

Qualifications

The applicant should:

1. Hold a PhD in medical science/biological sciences/biochemistry/bioengineering/biomedical sciences or related disciplines;
2. Have extensive knowledge and >30 years’ experience in molecular biology, biochemistry or internal medicine;
3. Have a strong record of publications in international journals;
4. Be passionate about science, self-motivated, naturally take ownership of assignments, and proactively propose solutions to arising issues.

Interested applicants are invited to apply directly at the NUS Career Portal.Your application will be processed only if you apply via NUS Career Portal.
We regret that only shortlisted candidates will be notified.

My client is a risk and assurance company, supporting the maritime sector. This role will support RFx activities and negotiations, and supporting Global Category Managers with tactical procurement activities.

Job Description:

• Support RFx activities and negotiations
• Identify, develop, execute and monitor strategic sourcing
• Assist in improvement of Procurement governance, documentation, and P2P processes/system
• Track and support contract renewals, vendor performance management, and supplier audits
• Support Global Category Managers in tactical procurement activities
• Analyse spend data
• Track and report savings
• Assist in market benchmarking exercises and research
• Active support and collaboration with local and regional stakeholders for project implementations
• Provide new ideas and innovative solutions to the team

Requirements:

• Bachelor Degree
• Prior working experience in Procurement, Logistics or Supply Chain roles

Should you be interested in this position, please contact Terence at +65 9645 4048 your resume directly for fast respond.

We regret to inform that only shortlisted candidates will be notified.

By sending us your personal data and curriculum vitae (CV), you are deemed to consent to PERSOLKELLY Singapore Pte Ltd and its affiliates to collect, use and disclose your personal data for the purposes set out in the Privacy Policy available at https://www.persolkelly.com.sg/policies. You acknowledge that you have read, understood, and agree with the Privacy Policy.

PERSOLKELLY Singapore Pte Ltd • RCB No. 200007268E • EA License No. 01C4394• Reg. R23116141 Le Cong Thang