A Postdoctoral Scientist (Bioinformatician) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools Bioinformatician position

A Bioinformatician position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in healthy and diseased states, while developing novel tools and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• Ph.D./ M.Sc. from a well-recognized institution with a strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics and Spatial-seq
• Experience with open-source bioinformatics tools
• Excellent analytical, technical, and problem-solving skills
• Knowledge with biostatistics highly desirable
• Self-starter who is comfortable working in a fast-moving interdisciplinary team
• Committed and able to work flexible hours
• Excellent communication, technical writing, and presentation skills

Interested candidates are asked to send a cover letter detailing your research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]). Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

References:

1) Cipta NO, Chen Y, Loh YH#. H3.3 safeguards haematopoietic ERV-quilibrium Nature Cell Biology 2021(In press)

2) Gautam P, et al., Loh YH#. Multi-species single-cell transcriptomic analysis of ocular compartment regulons. Nature Communications 2021 Sep 24; 12, 5675 #As Corresponding author

3) Xing QR, et al., Loh YH#. Diversification of Reprogramming Trajectories Revealed by Parallel Single-cell Transcriptome and Chromatin Accessibility Sequencing. Science Advances. 2020 Sep 11. 6:37, eaba1190. doi: 10.1126/sciadv.aba1190

4) Xing QR, et al., Loh YH#. Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility. Genome Research 2020 Jul;30(7):1027-1039. doi: 10.1101/gr.257840.119.

5) Fang HT, et al., Loh YH#. Global H3.3 dynamic deposition defines its bimodal role in cell fate transition. Nature Communications 2018 Apr 18;9:1537

6) Yang BX, et al., Loh YH#. Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell 2015163(1):230-45

7) Agarwal S, Loh YH, et al., Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464, 292-296.

8) Loh YH et al., Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nature Genetics 2006 38, 431–440.and strategies in deriving desired cell types for therapeutic applications.

Applicants with strong background in Bioinformatics and next-generation sequencing data analysis are invited to apply. Successful candidates must be highly motivated, have passion for research and be able to work in an interdisciplinary environment.

Requirements:

• PhD with strong research background in Bioinformatics/ Computer science/ Biostatistics or equivalent.
• Experience in bioinformatics and data analysis for ChIP-seq, Transcriptomics, Single-cell analytics, and Spatial-seq.
• Experience with open-source bioinformatics tools.
• Excellent analytical, technical, and problem-solving skills.
• Knowledge of biostatistics highly desirable.
• Self-starter who is comfortable working in a fast-moving interdisciplinary team.
• Strong publication record in peer-reviewed journals.
• Committed and able to work flexible hours.
• Excellent communication, technical writing, and presentation skills.

Interested candidates are asked to send a cover letter detailing their research motivations, CV, and the names and email addresses of three references to Jonathan Loh ([email protected]).

Applicants can visit the lab website to find out more (http://www.imcb.a-star.edu.sg/php/jl.php).

The Institute of Molecular and Cell Biology (IMCB) is a premier research institute at A*STAR whose mission is to harness biology for transformational bio-therapeutics and diagnostics. In this role, you will be working with the IMCB researchers, grant agencies as well as A*STAR finance, councils, and the central research office to provide relevant grant-related support to the institute.

Job Description: the role includes, but is not limited to, the following:

• Ensure that all grant proposal submissions meet the requirements as set by the respective granting agency.
• Review annual progress reports and final reports for various grants and ensure that these are submitted on time.
• Attend to requests from the granting agencies pertaining to budget scrubbing, letter of award and other steps required for timely activation of new grants.
• Assist investigators with changes related to their grants (deviation/variation requests).
• Work closely with A*STAR research office, councils, and finance regarding ad hoc requests for grant-related data and pending tasks.
• Serve as the institutional admin and help with creation and activation of accounts for grant-related portals such as IGMS and iGrants.
• Tabulate and track the grants of the institute to ensure easy extraction of grant data whenever required.
• Promptly attend to grant-related queries from investigators.
• Define timelines for internal review and approval SOP of grant calls and communicate to researchers for grant applications.
• Monitor, report and analyse grant application activities as well provide timely updates to management on grant status.

Requirements:

• Minimum Bachelor’s degree, preferably in Life Science or equivalent.
• Preferably with at least 3 years of working experience.
• Experience and/or keen interest in work related to governance/ policy/ research administration, especially in the research & development sector, is an advantage.
• Good team player with excellent written and oral communication skills.
• Excellent time management skills.
• Meticulous, resourceful, able to multi-task and work independently.
• Able to work collaboratively with internal and external stakeholders across functional groups and levels.
• Interested in science and technology.
• Proficient in M365 and related applications.
• Prior experience in dashboard reporting and/or project management is a plus.

The Advanced Molecular Pathology Laboratory (AMPL) is a GLP laboratory at IMCB that provides key support to conducting cutting-edge biomedical research and development with a specific focus on laboratory animal histology and pathology. As part of the dynamic team in this laboratory, you will be responsible for providing services to support the needs of researchers. AMPL also provides veterinary diagnostic biopsy services to Singapore’s veterinary community.

Responsibilities:

• Operate histology laboratory equipment to provide histology services to research and the veterinary community.
• Provide high-quality technical services and expertise to researchers in the areas of complex animal tissue collection and processing procedures, as well as other laboratory procedures such as necropsy, tissue embedding, cryotomy, microtomy, histology slide staining, etc.
• Maintain equipment, reagents, and consumables, etc in good working order to ensure continuity of services.
• Involve in QA audit and/or archiving for GLP compliance.
• Handle routine laboratory administration and scheduled duties.

Requirements:

• Diploma in Life Sciences, Biological Sciences, or a related field.
• Good basic laboratory skills and manual dexterity.
• Meticulous and organized with an ability to multi-task.
• Good communication, interpersonal and analytical skills.
• Able to work independently and as well as with a team in a fast-paced environment.
• Willing to work in a service-based environment and provide technical advice and support Record/invoice maintenance/handling.
• Familiarity with histopathology techniques and GLP would be an advantage

Job Description
A Postdoctoral Immunologist (Scientist) position is available immediately at the IMCB Cell Fate and Therapeutics Laboratory. The lab is interested in dissecting the regulatory switches regulating cell fate determination in immune cell types while developing novel tools and strategies for deriving desired cell types for therapeutic applications.

Applicants with a strong background in stem cells and immunology, including CAR-T cells, are invited to apply. Successful candidates must be highly motivated, have a passion for research and be able to work in an interdisciplinary environment.

Job Requirements:

• Ph.D. with a strong research background in Immunology
• Experience in stem cell expansion and characterization
• Excellent analytical, technical and problem-solving skills
• Knowledge of biostatistics highly desirable
• Self-starter who is comfortable working in a fast-moving interdisciplinary team
• Strong publication record in peer-reviewed journals
• Committed and able to work flexible hours
• Excellent communication, technical writing and presentation skills

Interested applicants can contact Dr Jonathan Loh (Principal Investigator) at [email protected].

AWARE, Singapore’s leading gender equality advocacy group, is seeking a passionate and dedicated Senior Programme Executive to join our CARE Services. This is your chance to directly impact the lives of women and survivors of sexual assault by supporting our crucial Women’s Care Centre (WCC) and Sexual Assault Care Centre (SACC).

More than just a job, this is a chance to:

• Make a tangible impact on the lives of women facing challenges
• Work alongside a team of professionals committed to gender equality
• Develop your skills in project management, advocacy and client support
• Contribute to innovative initiatives that support and protect women

Position: Senior Programme Executive
Department: CARE
Commitment: Contract, full time
Salary range: SGD$3,880-4,380
Starting date: Immediate

What you’ll do:

• Plan, coordinate, and execute CARE services, ensuring seamless operations and a client-centric approach
• Partner with service teams, volunteers, and stakeholders to build a supportive network for survivors
• Leading and supporting short-term and long-term initiatives that promote awareness, prevention, and policy change
• Provide emotional and practical support to clients, fostering healing and resilience
• Build and nurture relationships with internal and external partners to amplify impact

Are you the one we’re looking for?

• 3+ years of experience coordinating services or related projects/programmes
• Social work or related field qualifications and experience in the social sector (desired)
• Strong project management skills: analytical, organised, detail-oriented, with excellent report writing and documentation abilities
• Empathy, adaptability, and a collaborative spirit to thrive in a supportive and fast-paced environment
• Confidentiality, proficiency in MS Office and Google Suite, and excellent English communication skills (verbal and written)
• Strong belief in gender equality and the values of AWARE

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Please note that, due to the large number of applications, only shortlisted applicants will be contacted for an interview. If you have any questions about this position, please email [email protected].

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

• The Research Assistant will work closely with the Principal Investigator on several research projects on using machine learning in chemical and control engineering problems
• The Research Assistant will help to develop machine learning models for both theory and applications in advanced control systems

Job Requirements

• A Bachelor degree in a relevant area, e.g., Chemical Engineering, Control Engineering, Computer Science, Chemistry, etc.
• Experienced in machine learning, optimization and programming languages (e.g., python, Matlab, C++, etc)
• Any experience with 1) advanced control, 2) machine learning theory and applications, and 3) chemical engineering and chemistry is a plus

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: Master’s degree in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: At least 2 years’ relevant work experience

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Research Assistant will work closely with the Principal Investigator (PI) to design and build desirable microstructure to enhance mechanical properties of steels by additive manufacturing.

The job scope of this position is:

• Conducting literature reviews and understanding state of the art
• Planning and implementing experiments
• Developing simulation models to guide microstructural engineering
• Analysing the experimental and simulation data
• Writing progress reports and research papers

Qualifications

• Bachelors/Masters Degree in Materials Science or Mechanical Engineering
• Knowledge of metallurgy and microstructural engineering is highly required
• Expertise in microstructural characterisation techniques (e.g. TEM, EBSD and FIB) and mechanical testing
• Expertise in numerical simulations (e.g. phase field, FEM)
• Experience with metal additive manufacturing (e.g. powder bed fusion, directed energy deposition) will be advantageous
• Good publication record will be advantageous
• Self-motivated, good team player

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof YAO Shao Qin on chemical biology/drug discovery-related research under a project on "Targeted covalent Inhibitors against key epigenetic proteins (NMRC)".

Human kinases and epigenetic proteins are important therapeutic targets. Recent development of selective and potent inhibitors of proteins has yielded remarkable results in disease treatment, with numerous drugs already on the market, and many more undergoing clinical trials. Notwithstanding, the discovery of new covalent kinase and epigenetic drugs remains highly challenging, including issues related to selectivity, efficacy and acquired drug resistance. Taking cue from the kinase drug discovery field, the hypothesis of these projects is that a universal strategy for targeted covalent inhibitors (TCIs) capable of potent target inhibition and minimal acquired drug resistance is possible, if highly effective small molecules could be developed to covalently target non-cysteine (C) nucleophilic residues within/near the active-site of kinase/epigenetic proteins. Our recent discovery of covalent kinase inhibitors against BCR-ABL (a key kinase for CML) in which CBA/SA and EBA warheads formed stable, (reversible and irreversible) covalent linkage with catalytic lysine (K) in Abl kinase under cellular environments indicates other covalent chemistries are feasible. Therefore, the goal of the current proposals is to confirm covalent chemistries targeting other nucleophilic residues (E/D/R/M/etc) are possible, and amenable to the development of cell-active, selective TCIs for various therapeutic proteins.

The scope of this proposal will be limited to the fundamental basic science, and NOT the actual clinical implementation, of the developed chemical/chemical biology tools. Therefore, only cell-based and basic animal models will be tested on newly developed, select small-molecule TCIs. Experience/skills required are organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology (only some of above skills are required)

Qualifications

• Qualifications / Discipline: PhD or equivalent in Chemistry/Biochemistry/Pharmaceutical Chemistry/Biology
• Skills: Organic synthesis/chemical biology/protein chemistry/proteomics/molecular biology/cell biology
• Experience: Fresh PhD graduates or PhD holders with < 5 years of experience in any/some of above fields

We are looking for a highly motivated research officer who is interested in developing next-generation DNA and RNA therapeutics for treating genetic diseases. The individual will be involved in a multi-disciplinary project to develop new technologies and tools for precision editing of nucleic acids. There will be opportunities to further develop techniques in protein engineering, directed evolution, and synthetic biology.

Responsibilities:

• Design and clone constructs for experiments
• Perform activity characterization in vitro and in mammalian cells
• Perform qPCR/RT-qPCR of mammalian cells
• Perform high-throughput sequencing library preparation
• Analyze data and communicate results of experiments to colleagues
• Maintenance of laboratory equipment and general laboratory supplies

Job Requirement

• Bachelor’s Degree in Biochemistry, Biotechnology, Bioengineering, Biological Sciences, Chemistry, Chemical Engineering, or other related fields
• Experience with mammalian cell culture and molecular biology techniques (eg. molecular cloning, PCR, gel electrophoresis, miniprep)
• Experience with flow cytometry, protein expression, bacteriophage, high-throughput sequencing, or bioinformatics will be valued
• Excellent organizational and interpersonal skills
• Highly motivated, passion for science, committed to laboratory work
• Ability to work independently and as part of a team
• Excellent communication (verbal and written) and presentation skills
• Curiosity to learn new knowledge and skills

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Dr Gloryn Chia on developing cancer vaccines.

We are seeking a highly motivated Research Fellow with expertise in immunology. Our team aims to leverage on stem cell biology (Sagi, Chia et al., Nature 2016; Chia et al., Nature Cell Biology 2019; Chia et al., Nature Cell Biology 2017) and cell engineering to develop alternative immunotherapeutic strategies to target refractory cancer types. The candidate will work closely with clinicians to establish empirical platforms for identifying and validating cancer vaccine candidates, and to translate research findings into clinical practice. Also, the candidate will be involved in the assessment and development of vaccines against novel antigens for the treatment of cancer and other human diseases. The successful candidate will need to independently design and execute experiments, troubleshoot issues, interpret results and give project updates. Highly motivated individuals with a passion for advancing personalized medicine are encouraged to apply.

We provide a highly competitive remuneration package that commensurates with the qualifications and relevant experience of the successful candidate.

The laboratory is supported by generous funds from the National Research Foundation Fellowship (NRF 2020). For more information, please visit http://pharmacy.nus.edu.sg/gloryn-chia-laboratory/

Qualifications

The main responsibilities of the position include:
Performing and designing experiments

• Qualifications / Discipline:
PhD in Immunology or relevant disciplines

• Skills: Cell culture, molecular cloning, etc.

• Experience:
Research experience

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The Mechanobiology Institute, Singapore, is a multidisciplinary institute committed to developing new paradigms for biomedical research by focusing on the quantitative analysis of dynamic functional processes. Through quantitative biophysical approaches, we address major problems in biomedical sciences, including pathogenesis (from bacterial to cancer), tissue regeneration, and function.

Asst. Prof. Chan seeks a highly motivated individual to join his laboratory on Mammalian Development and Tissue Hydraulics as a postdoctoral fellow at the Mechanobiology Institute in the National University of Singapore. This position is offered under a highly interdisciplinary project that aims to understand macrophage-environment mechanochemical crosstalk during ovarian ageing.

Project Scope

The candidate will investigate the mechanobiological principles by which cell mechanics, ECM remodelling and inflammation drive fibrosis during ovarian ageing. The selected candidate will combine an ex vivo approach with advanced imaging, omics and biophysics to explore how tissue-resident macrophages respond to age-associated changes in matrix stiffness and composition, and how this in turn drives macrophage-mediated fibrosis. To learn more, please refer to the relevant publication by the lab: Front Cell Dev Biol. 2022; 10: 1038107.

Qualifications

Candidates should hold a PhD, or be in the final stages of their PhD, in one of the disciplines below:

• Tissue engineering
• Cell/ molecular/ tissue biology
• Cellular biophysics

Skills and Experiences

• Confocal bioimaging and quantitative image analysis
• Some experience in primary cell culture
• Experience in mice work would be advantageous
• Highly motivated and independent; open to feedback
• Excellent written and interpersonal communication skills; able to work well in an interdisciplinary team

Applications should include a description of their research interests, their CV and the names and contacts of 2-3 references in their application. The application deadline is 15 March 2024.

Job Responsibilities

• Lead, manage and implement end-to-end projects related to IT Infrastructure (including Cloud) according to project governance.
• Work with internal business and other stakeholders to understand and analyse business requirements, translate business IT requirements to technical requirements.
• Work out full-scaled and precise proposal with technical solution team, coordinate and communicate resource and define clear roles with all project resources.
• Work onsite in a bank and manage vendors to ensure project delivery within schedule & budget and expected quality.
• Manage the communication and arrangement internally and externally.

Job Requirements

• Bachelor’s degree in information technology, Computer Science or equivalent.
• Min. 8 years of experiences as Project Manager in a bank in IT Infrastructure.
• Experience in Cloud related project implementation.
• Experience of Vendor management.
• Knowledge of IT security, Risk Management and Security Control.
• Ability to handle multiple projects concurrently.
• Possess good initiative and proactive in approach.
• Excellent communication, presentation and interpersonal skills.
• Project Management certification (e.g., PMP, PRINCE 2) is a plus.
• Experience in Agile Project Management methodology is an advantage.
• Certification in ITIL and Cloud related is a plus.
• Knowledge of IT regulation in APAC countries.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

The successful candidate will work with Prof. Noah Lim under a project on Multicomponent Formulations For Coatings That Increase The Shelf Life of Perishable Goods.

The main responsibilities of the position include:
1. Participate in project operation.
2. Fruit market survey.
3. Screening and optimization of edible components for fruit extension shelf-life coating formulation.
4. Structure analysis of formulated coating/thin film

Qualifications

• Qualifications / Discipline: Bachelor Degree in Chemistry/Materials/Food Science and Technology.

• Skills: SEM, Confocal Microscope, FTIR, HPLC, sensory evaluation, etc.

• Experience: With expertise in food science, formulation development, polymer science, biomaterials.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

• Polymer Synthesis
• Nanomaterials Synthesis
• Self-Assembly, particularly crystallization-induced self-assembly
• Mentor PhD students
• Draft grant proposals
• Oversee lab safety

Job Requirements

• PhD degree in chemistry, materials science and engineering, electric and computer engineering, or chemical engineering.
• Ample research experience in polymer synthesis (particularly ATRP, RAFT and ROMP), nanomaterials synthesis, and self-assembly of polymers and nanomaterials into hierarchical structures
• Solid background/experience in materials for self-assembly and catalysis.
• Excellent communication and writing skills
• Strong publication record
• Prior undergraduate and master students mentoring experience

Job Description

The Visiting Professor(VP) is expected to:

1. Manage and drive one or more translational research projects, design and execute experiments, assimilate and interpret results;
2. Solve scientific problems, think independently, and suggest creative solutions;
3. Write papers together with the PI for publications or patents and collaborations;
4. To provide advice and networking connectivity for the strategic planning and success of Synthetic Biology Translational Research Program;
5. Provide research strategic directions to researchers and mentorship to PI, researchers, postgraduate and undergraduate students.

Qualifications

The applicant should:

1. Hold a PhD in medical science/biological sciences/biochemistry/bioengineering/biomedical sciences or related disciplines;
2. Have extensive knowledge and >30 years’ experience in molecular biology, biochemistry or internal medicine;
3. Have a strong record of publications in international journals;
4. Be passionate about science, self-motivated, naturally take ownership of assignments, and proactively propose solutions to arising issues.

Interested applicants are invited to apply directly at the NUS Career Portal.Your application will be processed only if you apply via NUS Career Portal.
We regret that only shortlisted candidates will be notified.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

Sustainable Bio-platform for High Quality Microbial Protein Production. To perform experimental and simulation work on system integration sand life cycle assessment .

Job Requrements

Ph.D. degree in Chem. Eng. and related research areas.

Experience researcher in chemical, biomedical, and environmental engineering. System integration and LCA background will be desirable.

Recipient of the esteemed International Translational Neuroscience Award, Dr. Yan, a pioneer in Brain Tumor research, joins IMCB to establish the NeuroPhenomics Lab. This lab marks a new chapter in our quest for profound biological insights and their translation into biomarkers and therapies.

The lab"s mission revolves around a profound exploration of brain tumor biology, particularly focusing on key driver mutations like IDH1 and IDH2. These mutations, significant in the development of aggressive malignant gliomas, are pivotal in altering chromatin and genome methylation, thus influencing tumor evolution. The lab extends this research by identifying other genetic alterations with potential clinical relevance.

Dedicated to exploring new frontiers, the NeuroPhenomics Lab integrates advanced techniques in genetics, epigenetics, and metabolomics at both single-cell and spatial levels. This approach allows for a detailed examination of tumor cell diversity and their interactions within the microenvironment. The lab also investigates neurometabolism, emphasizing the TCA cycle and IDH enzymes, and studies how metabolites affect the brain and tumor progression.

Aiming to bridge research and clinical application, the lab"s multi-dimensional strategy includes iPSCs, patient-derived organoids, transgenic models, and advanced imaging technologies. This positions the NeuroPhenomics Lab at the forefront of developing transformative therapies in neurooncology and neurometabolism.

Job Opportunity:

Join the NeuroPhenomics Lab in its endeavor to redefine brain tumor genomics. We seek individuals with a strong background in Computer Science or Bioinformatics, particularly in data analysis, to contribute to our innovative research.

Key Qualifications:

• PhD in Bioinformatics, Computer Science, Biostatistics, or a related field with a research focus.
• Individuals planning to pursue PhD training (at NUS or NTU) are also welcome to apply.
• Expertise in bioinformatics and next-generation sequencing data analysis.
• Experience with Single-cell sequencing and Spatial-omics data analysis is a plus.
• Familiarity with developing AI models for visual recognition of imaging data.
• Experience in applying research to train Large Language Models (LLM) is advantageous.
• Preferred experience in Computer-Aided Drug Discovery.
• Exceptional analytical, technical, and problem-solving skills.
• Ability to work independently and thrive in a dynamic team environment.

Interested applicants are invited to apply directly at the NUS Career Portal.

Your application will be processed only if you apply via NUS Career Portal.

We regret that only shortlisted candidates will be notified.

Job Description

We are seeking to hire a motivated Research Fellow with background in engineering to work on microfluidic related research. Our lab (http://www.bioeng.nus.edu.sg/nanolab/index.html) is dedicated to microfluidics research with applications in the areas of cancer diagnosis, point-of-care diagnostics, cell based assays and wearable sensor technology. Candidate will have the opportunity to work on these various areas of research and be involved in the design and fabrication of microfluidic devices as well as collaborating with our clinical partners on the testing, validation and possible commercialization of these devices.

Qualifications

Applicant should have:
• PhD degree in chemical engineering, mechanical engineering or biomedical engineering or its equivalent
• Experience in microfluidics research, microfabrication, cell culture, microscopy and image analysis is preferred
• Highly motivated, organized and responsible individual who can work independently as well as part of a team.
• Be prepared to engage in high interdisciplinary research and develop new research directions.
• Ability to help mentor, supervise and train junior staff members and students.
• Proven record of outstanding written, oral presentation and communications skills.
• Excellent skills in project management.
• Ability to work on grant proposals including writing, meeting with collaborators, and reviewing proposal opportunities from government and other sources.
• Open to fixed-term contract.

We are seeking an experienced and dedicated Senior/Lead Network Engineer to join A*CRC Network Group. The candidate will be responsible for the planning, designing, implementing and maintaining the network infrastructure to support organization needs, ensuring reliability, performance and security for A*CRC.

Job Description

• Responsible for the planning, designing, configuration and administration of A*CRC network.
• Ensure continued smooth and optimal network performance for A*CRC services.
• Lead and participate in projects involving internal and external collaborators.
• Perform network evaluation, proof of concepts and provide recommendations.
• Required to develop network and network security related technical specifications for tenders.
• Work on improving processes and automation for network infrastructure.
• Manage daily network operations.

Job Requirement

• A bachelor’s degree in Computer Science/Computer Engineering/Networking or equivalent.
• CCNP certified or equivalent.
• 3 years of working experiences and in-depth understanding of networking technologies (e.g., WAN, LAN, Network Security, DWDM etc).
• Strong knowledge and troubleshooting skills in routing and switching (e.g., BGP, OSPF, VXLAN, MP-BGP EVPN, VRF etc.).
• Experienced in planning, implementing and commissioning of IP network.
• Proficient in managing routers, switches, network firewalls, intrusion prevention systems, vulnerability assessment and Network monitoring systems.
• Working knowlege in Linux environment and scripting language such as python to automate network procedures will be preferred.
• Possess strong analytical, troubleshooting and problem-solving skills.
• Independent mature team player with positive attitude.

We have a few openings for Research Fellow or Research Engineer. The selected applicant is expected to lead and pursue high-quality research in applied artificial intelligence (e.g., physics-informed neural network, transfer learning, and edge intelligence) for battery management systems that lead to publications in top-tier international conferences and journals, as well as real-world implementations. If interested, please send your resume including a cover letter, CV and a brief statement of your work undertaken in previous work.

The Singapore Institute of Technology (SIT) is a public autonomous university and the third largest university by intake in Singapore. SIT’s mission is to innovate with industry, through an integrated applied learning and research approach, so as to contribute to the economy and society. Singapore is the small city with a big dream. We are home to the best talent and have the world’s highest per capita investment in science and technology.

Key Responsibilities:

• Collaborate with partners from both the academia and the industry to lead and/or conduct innovative research on, but not limited to physics-informed neural network, transfer learning, and edge intelligence, battery management, etc.
• Contribute to academic research in the relevant domains and publish high-tier journal papers and conference papers.
• Participate in and manage the research project with Principal Investigator (PI) to ensure all project deliverables are met.
• Coordinate procurement and liaison with vendors/suppliers.
• Participate in computer science related laboratories and tutorials for undergraduate students.
• Interview and supervise student assistants in the project.

Job Requirements:

• (Research Fellow) PhD in Computer Science or a related field
• (Research Engineer) Bachelor/Master degree in Computer Science or a related field
• Proven ability to conduct independent research with a relevant publication record
• Outstanding data analytics, mathematical, and computer modelling skills
• Excellent interpersonal communication and oral presentation skills in English
• Self-driven and strong team spirit
• Open to fixed-term contract (renewable upon review of satisfactory performance)

• Position: Medical/Clinical Trial/Research Writer (Pharmaceutical/Medical Device)
• Location: Near Bras Basah MRT /Bencoolen MRT
• Working Hours: Monday to Friday| 9.00am to 6.00pm
• Salary (commensurate with experience): Up to $6,500 + Performance Bonus + Travel Allowance + 14 Days Annual Leave + Medical Benefits and Annual Check-up + Online Learning Portal for self-development + WFH Opportunities
• Duration: 1 Year Contract (RENEWABLE/CONVERTIBLE TO PERMANEMT)
• Industry: Digital Media Marketing Agency
• Career Advancement: Career growth plan

Responsibilities:

• Scientific liaison between clinical development and commercial operations in the pharmaceutical and device industries. It necessitates the capacity to
• Collaborate closely with medical regulatory authorities, healthcare professionals (HCPs), and
• Key Opinion Leaders (KOLs) to produce well-crafted content that is scientifically robust,
• Patient-centric, and aligns with the strategic positioning of pharmaceutical or medical device products.
• Remain up to date with recent trends and curate medical topics for scientific meetings, thereby fostering opportunities to enhance patient outcomes.

Requirements:

• Candidate should preferably possess a first-degree degree in biomedical science; a
• research-based degree (MSc or Ph.D.)
• At least 3-5 years of experience in Medical Communication Agency or equivalent
• Experience in managing topics and programme for AD Board Meetings and Scientific Conferences.

Email to [email protected]

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Joie Chang

Associate Consulting Director (APAC)

Reg no.: R2090601 | EA No: 13C6684

Scientist for Advanced Photonics (Photonic Computing and Quantum Computing)

As part of IME’s Photonics & Sensors Department, the candidate will paticipate in various projects for the development of photonic computing, quantum photonics, or other photonic applications. This will include photonic circuit design, characterization, electro-optic integration, and verification of system functionalities. You will work closely with an excellent multidisciplinary team working on photonics, electronics, semiconductor process, integration, and fab operation.

Responsibilities:

• Design of photonic integrated circuits for advanced photonic applications, including but not limited to photonic computing, quantum photonics, etc.
• Development of optical testing platform for advanced photonic applications. This emphasizes on the application-specific testing with multi-channel in, multi-channel out.
• Development of electro-optic testing platform for advanced photonic applications. This focuses on the electro-optic integration and relevant high-speed control interface.
• Verification of electro-optic system functionalities. This emphasizes on the realization of targeted algorithm implemented on photonic integrated circuits, as well as data analysis, trouble-shooting and optimization.
• Preparation of technical presentations and papers for internal meetings, as well as conferences and journals.
• Collaborate with project team to ensure quality and on-time delivery for various projects. You will get a chance to expose to both industrial and academic projects.
• Performs other duties as assigned.

Qualifications:

• PhD in Integrated Photonics, Microelectronics, Opto-electronics, Physics or equivalent.
• Experience in one or more topics listed below is strongly preferred: Photonic computing, quantum computing, LiDar, optical switch array, compute-in-memory.
• Hands-on experience in photonic simulation using various electrical / photonics design software.
• Hands-on experience in photonics and microelectronic testing at circuit level or above.
• Strong communication, industry awareness, and problem-solving skills.
• Strong self-motivation and interest in the next-generation photonics technology development.

The above eligibility criteria are not exhaustive. A*STAR may include additional selection criteria based on its prevailing recruitment policies. These policies may be amended from time to time without notice. We regret that only shortlisted candidates will be notified.

As a Scientist, you will be responsible to generate CRISPR/Cas9 mediated edited human embryonic stem cells for ciliary genes, differentiation into airway epithelium, characterisation of ciliary defects, rescue of mutant phenotype with lipid nanoparticle packaged RNA.

Job Responsibilities:

• Use CRISPR/Cas9 gene editing to generate homozygous loss-of-function mutations in DNAI1, CCDC40 and CCDC39 genes in human embryonic pluripotent stem cell line, H9.
• Verify authenticity of the mutants using sequencing of the DNA, cDNA and also using western blotting to ensure loss of the corresponding proteins.
• Differentiate mutant and control cells into airway epithelium and assess the effects on ciliary differentiation and motility using immunofluorescence staining and confocal microscopy as well as video microscopy.
• Examine if lipid nanoparticle encapsulated wild-type RNAs for these genes are able to rescue the ciliary defects using immunofluorescence staining and confocal microscopy as well as video microscopy.

Job Requirements:

• PhD in Stem Cells/ Developmental Biology/ Genetics or other related disciplines.
• Strong research background in embryonic stem cell culture and manipulation, confocal microscopy.
• Proficiency in stem cell culture and gene editing in stem cells using CRISPR/Cas9.

We are seeking an experienced and dedicated Senior/Lead Network Engineer to join A*CRC Network Group. The candidate will be responsible for the planning, designing, implementing and maintaining the network infrastructure to support organization needs, ensuring reliability, performance and security for A*CRC.

Job Description

• Responsible for the planning, designing, configuration and administration of A*CRC network.
• Ensure continued smooth and optimal network performance for A*CRC services.
• Lead and participate in projects involving internal and external collaborators.
• Perform network evaluation, proof of concepts and provide recommendations.
• Required to develop network and network security related technical specifications for tenders.
• Work on improving processes and automation for network infrastructure.
• Manage daily network operations.

Job Requirement

• A bachelor’s degree in Computer Science/Computer Engineering/Networking or equivalent.
• CCNP certified or equivalent.
• 3 years of working experiences and in-depth understanding of networking technologies (e.g., WAN, LAN, Network Security, DWDM etc).
• Strong knowledge and troubleshooting skills in routing and switching (e.g., BGP, OSPF, VXLAN, MP-BGP EVPN, VRF etc.).
• Experienced in planning, implementing and commissioning of IP network.
• Proficient in managing routers, switches, network firewalls, intrusion prevention systems, vulnerability assessment and Network monitoring systems.
• Working knowlege in Linux environment and scripting language such as python to automate network procedures will be preferred.
• Possess strong analytical, troubleshooting and problem-solving skills.
• Independent mature team player with positive attitude.